Results 21 to 30 of about 985 (235)

Proteomic analyses of venom from a Spider Hawk, Pepsis decorata

Journal of Venomous Animals and Toxins including Tropical Diseases, 2023
Background: The composition of the venom from solitary wasps is poorly known, although these animals are considered sources of bioactive substances.
Matheus Nolasco, Douglas O. C. Mariano, Daniel C. Pimenta, Ilka Biondi, Alexsandro Branco   +4 more
doaj   +1 more source

Elucidating the Venom Diversity in Sri Lankan Spectacled Cobra (Naja naja) through De Novo Venom Gland Transcriptomics, Venom Proteomics and Toxicity Neutralization

Toxins, 2021
Inadequate effectiveness of Indian antivenoms in treating envenomation caused by the Spectacled Cobra/Indian Cobra (Naja naja) in Sri Lanka has been attributed to geographical variations in the venom composition. This study investigated the de novo venom-
Kin Ying Wong, Kae Yi Tan, Nget Hong Tan, Christeine Ariaranee Gnanathasan, Choo Hock Tan   +4 more
doaj   +1 more source

De Novo Assembly of Venom Gland Transcriptome of Tropidolaemus wagleri (Temple Pit Viper, Malaysia) and Insights into the Origin of Its Major Toxin, Waglerin

Toxins, 2023
The venom proteome of Temple Pit Viper (Tropidolaemus wagleri) is unique among pit vipers, characterized by a high abundance of a neurotoxic peptide, waglerin.
Choo Hock Tan, Kae Yi Tan, Nget Hong Tan
doaj   +1 more source

A Review of the Proteomic Profiling of African Viperidae and Elapidae Snake Venoms and Their Antivenom Neutralisation

Toxins, 2022
Snakebite envenoming is a neglected tropical disease (NTD) that results from the injection of snake venom of a venomous snake into animals and humans.
Benedict C. Offor, Beric Muller, Lizelle A. Piater   +2 more
doaj   +1 more source

Different Research Approaches in Unraveling the Venom Proteome of Naja ashei

Biomolecules, 2020
The dynamic development of venomics in recent years has resulted in a significant increase in publicly available proteomic data. The information contained therein is often used for comparisons between different datasets and to draw biological conclusions
Konrad Kamil Hus, Łukasz Marczak, Vladimír Petrilla, Monika Petrillová, Jaroslav Legáth, Aleksandra Bocian   +5 more
doaj   +1 more source

Chemically Regulated STING‐Activating Prodrugs of Deoxyribose Cyclic Dinucleotides Elicit Robust Immune Activation and Durable Antitumor Immunity

Angewandte Chemie, EarlyView.
All three diastereoisomers of an esterase‐sensitive phosphotriester dCDN prodrug demonstrate improved activity. The (Rp,Rp) diastereoisomer shows the highest activity with an EC50 of 1.7 nM in STING activation and displays the most pronounced antitumor activity via intravenous administration, significantly suppressing tumor proliferation, extending the
Zhiqiang Xie, Huimin Liu, Yuchen Yang, Xiaohan Sun, Jingwen Wang, Tianxiang Liu, Baifan Wang, Wenrui Qiu, Yiwen Sun, Yuting Bai, Yao Zhang, Dejun Ma, Rong Xiang, Shibo Li, Zhen Xi   +14 more
wiley   +2 more sources

Toxinologic and Pharmacological Investigation of Venomous Arthropods

Toxins, 2022
Arthropods comprise the largest group of living animals, including thousands of species that inhabit marine and terrestrial niches in the biosphere [...]
Gandhi Rádis-Baptista, Katsuhiro Konno
doaj   +1 more source

Bioinformatics-Aided Venomics

Toxins, 2015
Venomics is a modern approach that combines transcriptomics and proteomics to explore the toxin content of venoms. This review will give an overview of computational approaches that have been created to classify and consolidate venomics data, as well as ...
Quentin Kaas, David J. Craik
doaj   +1 more source

Analytical methods for honeybee venom characterization

Journal of Advanced Pharmaceutical Technology & Research, 2022
The discovery of new drugs has benefited significantly from the development of research in venomics, increasing our understanding of the envenomation processes.
Iouraouine El Mehdi, Soraia I Falcão, Saïd Boujraf, Harandou Mustapha, Maria G Campos, Miguel Vilas-Boas   +5 more
doaj   +1 more source

Omics Meets Biology: Application to the Design and Preclinical Assessment of Antivenoms

Toxins, 2014
Snakebite envenoming represents a neglected tropical disease that has a heavy public health impact worldwide, mostly affecting poor people involved in agricultural activities in Africa, Asia, Latin America and Oceania.
Juan J. Calvete, Libia Sanz, Davinia Pla, Bruno Lomonte, José María Gutiérrez   +4 more
doaj   +1 more source