Results 31 to 40 of about 47,637 (149)

Modulation of αv integrins by lebecetin, a viper venom-derived molecule, in experimental neuroinflammation and demyelination models

Scientific Reports
Several neurodegenerative diseases, such as multiple sclerosis and Parkinson’s disease, are linked to alterations in myelin content or structure. Transmembrane receptors such as integrins could be involved in these alterations.
Nour-elhouda Neili, Zaineb AbdelKafi-Koubaa, Jed Jebali, Khouloud Kaidi, Ghada Sahraoui, Melika Ben Ahmed, Najet Srairi-Abid, Naziha Marrakchi, Raoudha Doghri, Ines ELBini   +9 more
doaj   +1 more source

Neurotoxins Acting on TRPV1—Building a Molecular Template for the Study of Pain and Thermal Dysfunctions

Toxins
Transient Receptor Potential (TRP) channels are ubiquitous proteins involved in a wide range of physiological functions. Some of them are expressed in nociceptors and play a major role in the transduction of painful stimuli of mechanical, thermal, or ...
Florian Beignon, Margaux Notais, Sylvie Diochot, Anne Baron, Ziad Fajloun, Hélène Tricoire-Leignel, Guy Lenaers, César Mattei   +7 more
doaj   +1 more source

Application of an Extracellular Matrix-Mimicking Fluorescent Polymer for the Detection of Proteolytic Venom Toxins

Toxins, 2023
The cytotoxicity caused by snake venoms is a serious medical problem that greatly contributes to the morbidity observed in snakebite patients. The cytotoxic components found in snake venoms belong to a variety of toxin classes and may cause cytotoxic ...
Eric Wachtel, Matyas A. Bittenbinder, Bas van de Velde, Julien Slagboom, Axel de Monts de Savasse, Luis L. Alonso, Nicholas R. Casewell, Freek J. Vonk, Jeroen Kool   +8 more
doaj   +1 more source

Evaluation of the Lethal Potency of Scorpion and Snake Venoms and Comparison between Intraperitoneal and Intravenous Injection Routes

Toxins, 2014
Scorpion stings and snake bites are major health hazards that lead to suffering of victims and high mortality. Thousands of injuries associated with such stings and bites of venomous animals occur every year worldwide.
Naoual Oukkache, Rachid Eljaoudi, Noreddine Ghalim, Fatima Chgoury, Balkiss Bouhaouala, Naima Elmdaghri, Jean-Marc Sabatier   +6 more
doaj   +1 more source

One-Step Chromatographic Approach for Purifying Peptides and Proteins from Venoms

Separations
Animal venoms are intricate and teem with potential for groundbreaking medical advancements. Although traditional methods for purifying venom proteins are effective, they usually require complicated, multi-step processes that lead to lower yields.
Yasmine Boughanmi, Soioulata Aboudou, Kayané Boyadjian, Acil Charouandi, Sarra Bouzid, Thelma Barnetche, Pascal Mansuelle, Régine Lebrun, Didier Gigmes, Harold de Pomyers, Kamel Mabrouk   +10 more
doaj   +1 more source

Venom of the Brazilian spider Sicarius ornatus (Araneae, Sicariidae) contains active sphingomyelinase D: potential for toxicity after envenomation. [PDF]

PLoS Neglected Tropical Diseases, 2013
BACKGROUND:The spider family Sicariidae includes two genera, Sicarius and Loxosceles. Bites by Sicarius are uncommon in humans and, in Brazil, a single report is known of a 17-year old man bitten by a Sicarius species that developed a necrotic lesion ...
Priscila Hess Lopes, Rogério Bertani, Rute M Gonçalves-de-Andrade, Roberto H Nagahama, Carmen W van den Berg, Denise V Tambourgi   +5 more
doaj   +1 more source

Development and Efficacy of the Antivenom Specific to Severe Envenomations in Morocco and North Africa: Advancements in Scorpion Envenomation Management

Toxins
Scorpion envenomation poses a global public health issue, with an estimated 1,500,000 cases worldwide annually resulting in 2600 deaths. North Africa, particularly Morocco, experiences severe envenomations, mainly attributed to Androctonus mauretanicus ...
Bouchra Darkaoui, Ines Hilal, Soukaina Khourcha, Ayoub Lafnoune, Salma Chakir, Ayoub Aarab, Abdellah Moustaghfir, Ouafaa Aniq Filali, Naoual Oukkache   +8 more
doaj   +1 more source

African adders: partial characterization of snake venoms from three Bitis species of medical importance and their neutralization by experimental equine antivenoms. [PDF]

PLoS Neglected Tropical Diseases, 2015
BACKGROUND:An alarming number of fatal accidents involving snakes are annually reported in Africa and most of the victims suffer from permanent local tissue damage and chronic disabilities.
Danielle Paixão-Cavalcante, Alexandre K Kuniyoshi, Fernanda C V Portaro, Wilmar Dias da Silva, Denise V Tambourgi   +4 more
doaj   +1 more source

A Simple and Novel Strategy for the Production of a Pan-specific Antiserum against Elapid Snakes of Asia. [PDF]

PLoS Neglected Tropical Diseases, 2016
Snakebite envenomation is a serious medical problem in many tropical developing countries and was considered by WHO as a neglected tropical disease.
Kavi Ratanabanangkoon, Kae Yi Tan, Sukanya Eursakun, Choo Hock Tan, Pavinee Simsiriwong, Teeraporn Pamornsakda, Witthawat Wiriyarat, Chaiya Klinpayom, Nget Hong Tan   +8 more
doaj   +1 more source

Snake C-Type Lectins Potentially Contribute to the Prey Immobilization in Protobothrops mucrosquamatus and Trimeresurus stejnegeri Venoms

Toxins, 2020
Snake venoms contain components selected to immobilize prey. The venoms from Elapidae mainly contain neurotoxins, which are critical for rapid prey paralysis, while the venoms from Viperidae and Colubridae may contain fewer neurotoxins but are likely to ...
Huiwen Tian, Ming Liu, Jiameng Li, Runjia Xu, Chengbo Long, Hao Li, James Mwangi, Qiumin Lu, Ren Lai, Chuanbin Shen   +9 more
doaj   +1 more source