Results 31 to 40 of about 63,437 (344)
Current Biology, 2009 The compounds that we recognize as toxins and venoms span an enormous diversity of pharmacological and ecological functions. The selection pressures driving the modification of venoms and toxins are fundamentally different from those of other proteins, and result in somewhat different evolutionary dynamics.
openaire +3 more sources
Pharmaceuticals, 2022 Scorpion stings are a public health event in Colombia lacking official epidemiological data, and are considered a medical emergency. Despite the two local producers of antivenoms, neither of them is currently manufacturing scorpion antivenoms. We present
Sebastian Estrada-Gomez +4 more
doaj +1 more source
The electronic structure and dipole moment of charybdotoxin, a scorpion venom peptide with K+ channel blocking activity [PDF]
Computational and Theoretical Chemistry 963 (2011) 384-393, 2010 The electronic structure of charybdotoxin (ChTX), a scorpion venom peptide that is known to act as a potassium channel blocker, is investigated with the aid of quantum mechanical calculations. The dipole moment vector (145 D) of ChTX can be stirred by the full length KcsA potassium channel's macrodipole (403 D) thereby assuming the proper orientation ...
arxiv +1 more source
Dramatic expansion of the black widow toxin arsenal uncovered by multi-tissue transcriptomics and venom proteomics. [PDF]
, 2014 BackgroundAnimal venoms attract enormous interest given their potential for pharmacological discovery and understanding the evolution of natural chemistries.
Ayoub, Nadia A +4 more
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Discovering Venom-Derived Drug Candidates Using Differential Gene Expression
Toxins, 2023 Venoms are a diverse and complex group of natural toxins that have been adapted to treat many types of human disease, but rigorous computational approaches for discovering new therapeutic activities are scarce.
Joseph D. Romano +6 more
doaj +1 more source
Does the traditional snakebite severity score correctly classify envenomated patients? [PDF]
Clinical and Experimental Emergency Medicine, 2016 Objective This study aims to help set domestic guidelines for administration of antivenom to envenomated patients after snakebites. Methods This retrospective observational case series comprised 128 patients with snake envenomation.
Seungho Kang +2 more
doaj +1 more source
Harnessing the Power of Venomous Animal-Derived Toxins against COVID-19
Toxins, 2023 Animal-derived venoms are complex mixtures of toxins triggering important biological effects during envenomings. Although venom-derived toxins are known for their potential of causing harm to victims, toxins can also act as pharmacological agents. During
Isadora Oliveira +8 more
doaj +1 more source
Are ticks venomous animals? [PDF]
Frontiers in Zoology, 2014 As an ecological adaptation venoms have evolved independently in several species of Metazoa. As haematophagous arthropods ticks are mainly considered as ectoparasites due to directly feeding on the skin of animal hosts. Ticks are of major importance since they serve as vectors for several diseases affecting humans and livestock animals.
Cabezas Cruz, Alejandro +1 more
openaire +6 more sources
Watch out Venomous Snake Species: A Solution to SnakeCLEF2023 [PDF]
arXiv, 2023 The SnakeCLEF2023 competition aims to the development of advanced algorithms for snake species identification through the analysis of images and accompanying metadata. This paper presents a method leveraging utilization of both images and metadata. Modern CNN models and strong data augmentation are utilized to learn better representation of images.
arxiv
Purification of a fragment obtained by autolysis of a PIIIb-SVMP from Bothrops alternatus venom [PDF]
, 2018 Snake Venom Metalloproteinases (SVMPs) represent 43.1% of the components in Bothrops alternatus venom and play an important role in envenomation. Disintegrins and disintegrin-like domains are released by proteolytic processing of PII and PIII classes of ...
Acosta, Ofelia Cristina +9 more
core +1 more source