Results 41 to 50 of about 11,226 (259)

Secreted Phospholipases A2 of Snake Venoms: Effects on the Peripheral Neuromuscular System with Comments on the Role of Phospholipases A2 in Disorders of the CNS and Their Uses in Industry

Toxins, 2013
Neuro- and myotoxicological signs and symptoms are significant clinical features of envenoming snakebites in many parts of the world. The toxins primarily responsible for the neuro and myotoxicity fall into one of two categories—those that bind to and ...
John B. Harris, Tracey Scott-Davey
doaj   +1 more source

Screening Snake Venoms for Toxicity to Tetrahymena Pyriformis Revealed Anti-Protozoan Activity of Cobra Cytotoxins

, 2020
Snake venoms possess lethal activities against different organisms, ranging from bacteria to higher vertebrates. Several venoms were shown to be active against protozoa, however, data about the anti-protozoan activity of cobra and viper venoms are very ...
Vladislav Starkov, Elena Kruykova, Victor Tsetlin, Elena Cheremnykh, Olga Kuleshina, Yuri Utkin, Alexey Osipov, Leonid Kozlov, Rustam Ziganshin, Tatyana Andreeva   +9 more
core   +1 more source

Two related thrombin-like enzymes present in Bothrops atrox venom

Brazilian Journal of Medical and Biological Research, 2000
This article describes the presence of two new forms of a thrombin-like enzyme, both with apparent molecular masses of 38 kDa, in Bothrops atrox venom. Both share the ability to cleave fibrinogen into fibrin and to digest casein.
J.H. Petretski, M. Kanashiro, C.P. Silva, E.W. Alves, T.L. Kipnis   +4 more
doaj   +1 more source

Snake C-Type Lectins Potentially Contribute to the Prey Immobilization in Protobothrops mucrosquamatus and Trimeresurus stejnegeri Venoms

, 2020
Snake venoms contain components selected to immobilize prey. The venoms from Elapidae mainly contain neurotoxins, which are critical for rapid prey paralysis, while the venoms from Viperidae and Colubridae may contain fewer neurotoxins but are likely to ...
Hao Li, James Mwangi, Qiumin Lu, Chengbo Long, Chuanbin Shen, Ming Liu, Jiameng Li, Ren Lai, Huiwen Tian, Runjia Xu   +9 more
core   +1 more source

Proteomic and Transcriptomic Techniques to Decipher the Molecular Evolution of Venoms

, 2021
Nature’s library of venoms is a vast and untapped resource that has the potential of becoming the source of a wide variety of new drugs and therapeutics.
Reza Sharif-Naeini, Stephanie Mouchbahani-Constance   +1 more
core   +1 more source

Envenomation with Snake Venoms as a Cause of Death: A Forensic Investigation of the Decomposition Stages and the Impact on Differential Succession Pattern of Carcass-Attracted Coleopteran Beetles

Insects
Background: Coleoptera is the second-most significant insect group associated with decomposing carcasses, yet its role in the decomposition process and postmortem colonization following envenomation is poorly understood.
Abdelwahab Khalil, Abeer M. Salem, El-Sayed H. Shaurub, Ashraf M. Ahmed, Areej A. Al-Khalaf, Mahmoud M. Zidan   +5 more
doaj   +1 more source

Proteomic Investigations of Two Pakistani Naja Snake Venoms Species Unravel the Venom Complexity, Posttranslational Modifications, and Presence of Extracellular Vesicles

, 2020
Latest advancement of omics technologies allows in-depth characterization of venom compositions. In the present work we present a proteomic study of two snake venoms of the genus Naja i.e., Naja naja (black cobra) and Naja oxiana (brown cobra) of ...
Zia Mughal, Syed Abid Ali, Aisha Manuwar, Andreas Böhmert, Anwar Ullah, Ahmed Akrem, Benjamin Dreyer, Hartmut Schlüter, Christian Betzel   +8 more
core   +1 more source

A C-type lectin from Bothrops jararacussu venom can adhere to extracellular matrix proteins and induce the rolling of leukocytes

Journal of Venomous Animals and Toxins including Tropical Diseases, 2007
Purification of a lectin from Bothrops jararacussu venom (BjcuL) was carried out using agarose-D-galactose affinity gel. MALDI-TOF gave a major signal at m/z 32028, suggesting the presence of a dimmer composed of two identical subunits.
S. L. Elífio-Esposito, P. L. Hess, A. N. Moreno, M. Lopes-Ferreira, C. A. O. Ricart, M. V. Souza, F. Hasselman-Zielinski, J. A. Becker, L. F. Pereira   +8 more
doaj   +1 more source

Expression of the First Recombinant Anti-Tumoral Snake Venom Kunitz-Type Serine Protease Inhibitor

Toxins, 2022
PIVL is a Kunitz-type serine protease inhibitor that was previously characterized from Tunisian snake venom, Macrovipera lebetina transmediterranea. It reduced glioblastoma cells’ development and significantly blocked angiogenesis in in-vitro and ex-vivo
Maram Morjen, Wassim Moslah, Imen Touihri-Baraketi, Najet Srairi-Abid, José Luis, Naziha Marrakchi, Jed Jebali   +6 more
doaj   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source