Results 41 to 50 of about 23,074 (307)

Expression of the First Recombinant Anti-Tumoral Snake Venom Kunitz-Type Serine Protease Inhibitor

Toxins, 2022
PIVL is a Kunitz-type serine protease inhibitor that was previously characterized from Tunisian snake venom, Macrovipera lebetina transmediterranea. It reduced glioblastoma cells’ development and significantly blocked angiogenesis in in-vitro and ex-vivo
Maram Morjen, Wassim Moslah, Imen Touihri-Baraketi, Najet Srairi-Abid, José Luis, Naziha Marrakchi, Jed Jebali   +6 more
doaj   +1 more source

Envenomation with Snake Venoms as a Cause of Death: A Forensic Investigation of the Decomposition Stages and the Impact on Differential Succession Pattern of Carcass-Attracted Coleopteran Beetles

Insects
Background: Coleoptera is the second-most significant insect group associated with decomposing carcasses, yet its role in the decomposition process and postmortem colonization following envenomation is poorly understood.
Abdelwahab Khalil, Abeer M. Salem, El-Sayed H. Shaurub, Ashraf M. Ahmed, Areej A. Al-Khalaf, Mahmoud M. Zidan   +5 more
doaj   +1 more source

A new scenario of bioprospecting of Hymenoptera venoms through proteomic approach

Journal of Venomous Animals and Toxins including Tropical Diseases, 2011
Venoms represent a huge and essentially unexplored reservoir of bioactive components that may cure diseases that do not respond to currently available therapies.
LD Santos, M Pieroni, ARS Menegasso, JRAS Pinto, MS Palma   +4 more
doaj   +1 more source

Varespladib (LY315920) and Methyl Varespladib (LY333013) Abrogate or Delay Lethality Induced by Presynaptically Acting Neurotoxic Snake Venoms

, 2020
The phospholipase A2 (PLA2) inhibitor Varespladib (LY315920) and its orally bioavailable prodrug, methyl-Varespladib (LY333013) inhibit PLA2 activity of a wide variety of snake venoms.
Bruno Lomonte, Williams, David J., Lewin, Matthew R., Matthew R. Lewin, José María Gutiérrez, Lomonte, Bruno, Gutiérrez, José María, David. J. Williams   +7 more
core   +1 more source

Animal Venoms and Their Components: Molecular Mechanisms of Action

, 2021
Animal venoms comprise numerous toxin families, consisting mainly of peptides and proteins [...
Yuri Utkin
core   +1 more source

Potency Testing of Venoms and Antivenoms in Embryonated Eggs: An Ethical Alternative to Animal Testing

, 2021
Venoms are complex mixtures of biologically active molecules that impact multiple physiological systems. Manufacture of antivenoms (AVs) therefore requires potency testing using in vivo models to ensure AV efficacy. As part of ongoing research to replace
Erin E. Verity, Kathy Stewart, Chi Ong, Steven Rockman, Kirsten Vandenberg   +4 more
core   +1 more source

Health Care Use Among Patients Presenting to Emergency Department for Gout Flares in Ontario, Canada: A Population‐Based Health Systems Analysis

Arthritis Care &Research, EarlyView.
Objective We characterized emergency department (ED) gout visits and identified patient characteristics and health services patterns contributing to ED presentations. Methods We conducted a population‐based study of ED gout visits in Ontario, Canada, between 2014 and 2023.
Timothy S. H. Kwok, Samantha Morais, William K. Silverstein, Clare L. Atzema, Gregory Choy, Priyanka Chandratre, Ping Li, Jessica Widdifield   +7 more
wiley   +1 more source

One-Step Chromatographic Approach for Purifying Peptides and Proteins from Venoms

Separations
Animal venoms are intricate and teem with potential for groundbreaking medical advancements. Although traditional methods for purifying venom proteins are effective, they usually require complicated, multi-step processes that lead to lower yields.
Yasmine Boughanmi, Soioulata Aboudou, Kayané Boyadjian, Acil Charouandi, Sarra Bouzid, Thelma Barnetche, Pascal Mansuelle, Régine Lebrun, Didier Gigmes, Harold de Pomyers, Kamel Mabrouk   +10 more
doaj   +1 more source

The Nonpeptide Low Molecular Mass Toxins from Spider Venoms

, 2016
Spiders occupy most of the ecological niches of the planet, revealing a huge adaptive plasticity, reflected in the chemical diversity of their venom toxins.
DiegoGarcia, E., Gopalakrishnakone, P., Gomes, Paulo Cesar [UNESP], Corzo, G., Palma, Mario Sergio [UNESP], DeLima, M. E.   +5 more
core   +1 more source

Biological Effects of Animal Venoms on the Human Immune System

, 2022
Venoms are products of specialized glands and serve many living organisms to immobilize and kill prey, start digestive processes and act as a defense mechanism.
Cañas, Carlos A., María Claudia Barrera, Manuela Agudelo-Delgado, Tobón, Gabriel J., Avalo, Zharick, Carlos A. Cañas, Barrera, María Claudia, Agudelo-Delgado, Manuela, Gabriel J. Tobón, Zharick Avalo   +9 more
core   +1 more source