Results 31 to 40 of about 11,226 (259)

Varespladib (LY315920) and Methyl Varespladib (LY333013) Abrogate or Delay Lethality Induced by Presynaptically Acting Neurotoxic Snake Venoms [PDF]

, 2020
The phospholipase A2 (PLA2) inhibitor Varespladib (LY315920) and its orally bioavailable prodrug, methyl-Varespladib (LY333013) inhibit PLA2 activity of a wide variety of snake venoms.
Bruno Lomonte, Williams, David J., Lewin, Matthew R., Matthew R. Lewin, José María Gutiérrez, Lomonte, Bruno, Gutiérrez, José María, David. J. Williams   +7 more
core   +1 more source

Harnessing the Power of Venomous Animal-Derived Toxins against COVID-19

Toxins, 2023
Animal-derived venoms are complex mixtures of toxins triggering important biological effects during envenomings. Although venom-derived toxins are known for their potential of causing harm to victims, toxins can also act as pharmacological agents. During
Isadora Oliveira, Isabela Ferreira, Beatriz Jacob, Kiara Cardenas, Felipe Cerni, Djane Baia-da-Silva, Eliane Arantes, Wuelton Monteiro, Manuela Pucca   +8 more
doaj   +1 more source

Bothrops atrox and Bothrops lanceolatus Venoms In Vitro Investigation: Composition, Procoagulant Effects, Co-Factor Dependency, and Correction Using Antivenoms

, 2023
Bothrops venoms are rich in enzymes acting on platelets and coagulation. This action is dependent on two major co-factors, i.e., calcium and phospholipids, while antivenoms variably neutralize venom-related coagulopathy effects.
Rabah Gahoual, Anne-Laure Dupart, Sébastien Larréché, Virginie Siguret, Georges Jourdi, Pascale Gaussem, Jean-Philippe Chippaux, Aurore Bousquet, Christilla Bachelot-Loza, Lucie Chevillard, Bruno Mégarbane   +10 more
core   +1 more source

Venomous secretions from marine snails of the Terebridae family target acetylcholine receptors [PDF]

, 2013
Venoms from cone snails (Conidae) have been extensively studied during the last decades, but those from other members of the suborder Toxoglossa, such as of Terebridae and Turridae superfamilies attracted less interest so far. Here, we report the effects
Wunder, C., Peigneur, S., Silke Kauferstein, Melaun, Christian, Annette Nicke, Nicke, Annette, Dietrich Mebs, Christian Melaun, Peigneur, Steve, Kauferstein, S., Kauferstein, Silke, Wunder, Cora, Kendel, Y., Mebs, D., Kurz, A., Steve Peigneur, Tytgat, Jan, Melaun, C., Kendel, Yvonne, Kurz, Alexander, Mebs, Dietrich, Yvonne Kendel, Jan Tytgat, Cora Wunder, Alexander Kurz, Nicke, A., Tytgat, J.   +26 more
core   +1 more source

Hemorrhagic Activity and Hemostatic Alterations Caused by Cerastes cerastes and Daboia mauritanica: Indicators of Viper Bite Severity in Morocco [PDF]

BIO Web of Conferences
Snakebite envenoming is a major global public health problem, causing approximately 5 million bites and 150,000 deaths each year, particularly in North Africa, where viper bites lead to significant morbidity and mortality.
Mesmoudi Nihal, Hammani Noureddine, Ammouch Khawla, Ibenmoussa Samir, Moustaghfir Abdellah, Oukkache Naoual   +5 more
doaj   +1 more source

Differences between Two Groups of Burmese Vipers (Viperidae: Azemiops) in the Proteomic Profiles, Immunoreactivity and Biochemical Functions of Their Venoms

, 2022
Two recently revised Azemiops snakes with apparent differences in their external appearances and skeletal morphologies but unclear genetic boundaries have been proposed. Some researchers have refrained from using the newly proposed taxonomy because these
Gao, Jian-Fang, Zhao, Hong-Yan, Wen, Lin, Hong-Yan Zhao, Jian-Fang Gao, Zheng, Si-Rui, Lin Wen, Ji, Xiang, Yan Sun, Sun, Yan, Si-Rui Zheng, Xiang Ji   +11 more
core   +1 more source

Suramin inhibits the early effects of PLA(2) neurotoxins at mouse neuromuscular junctions: a twitch tension study [PDF]

, 2011
Several phospholipase A(2) (PLA(2)) neurotoxins from snake venoms can affect acetylcholine release at the neuromuscular junction. In isolated nerve-muscle preparations three distinct phases have been described for this phenomenon: An initial transient ...
Fathi, Behrooz, Rowan, Edward G, Harvey, Alan L   +2 more
core   +3 more sources

Field study on scorpions and scorpionism in the southeast of El Jadida, Morocco [PDF]

BIO Web of Conferences
Morocco has a rich and diverse fauna of scorpions. However, certain regions such as Boulaouane remain underdocumented despite their importance for public health.
Ammouch Khawla, Mesmoudi Nihal, Hammani Noureddine, Ibenmoussa Samir, Moustaghfir Abdellah, Oukkache Naoual   +5 more
doaj   +1 more source

Beyond spider personality: The relationships between behavioral, physiological, and environmental factors

Ecology and Evolution, 2021
Spiders are useful models for testing different hypotheses and methodologies relating to animal personality and behavioral syndromes because they show a range of behavioral types and unique physiological traits (e.g., silk and venom) that are not ...
Linda Hernández Duran, David Thomas Wilson, Mark Briffa, Tasmin Lee Rymer   +3 more
doaj   +1 more source

Does the traditional snakebite severity score correctly classify envenomated patients? [PDF]

Clinical and Experimental Emergency Medicine, 2016
Objective This study aims to help set domestic guidelines for administration of antivenom to envenomated patients after snakebites. Methods This retrospective observational case series comprised 128 patients with snake envenomation.
Seungho Kang, Jeongmi Moon, Byeongjo Chun   +2 more
doaj   +1 more source