Results 151 to 160 of about 5,048,560 (285)

Chronic, Environmentally Relevant PM2.5 Exposure Exacerbates Metabolic Dysfunction‐Associated Steatotic Liver Disease and Early‐Stage Renal Dysfunction in a Rodent Model

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT While epidemiological studies link fine particulate matter (PM2.5) exposure to metabolic dysfunction‐associated steatotic liver disease (MASLD) and renal dysfunction, a translational gap exists, as most animal models utilize acute, high‐dose exposures that poorly reflect chronic, moderate‐level human scenarios.
Yi‐Siao Chen, Hugo You‐Hsien Lin, Chien‐Tzu Lin, Si‐Hua Huang, Ming‐Lun Yeh, Ming‐Lung Yu, Jin‐Ching Lee, Yao‐Chi Chung, Wei‐Ming Li, Ching‐Chia Li, Shiu‐Feng Huang, Chia‐Hung Yen   +11 more
wiley   +1 more source

Use of very low tidal volumes during high-frequency ventilation reduces ventilator lung injury

, 2019
The use of volume guarantee (VG) on high-frequency oscillatory ventilation (HFOV) allows to use fixed very low high-frequency tidal volume (VThf), maintaining adequate CO2 removal while potentially reducing the risk of ventilator-induced lung injury ...
Manuel Sánchez-Luna, Tendillo Cortijo, Francisco Javier, Francisco Tendillo-Cortijo, González Pacheco, Noelia, Noelia González-Pacheco, Palau Concejo, Paula, Paula Palau-Concejo, Paz Chimenti-Camacho, Sánchez Luna, Manuel Ramón, Santos González, Martín, Martín Santos-González, Chimenti Camacho, Paz   +11 more
core   +1 more source

Covid-19 Pneumonia and Ventilation-induced Lung Injury: A Case Report. [PDF]

Rom J Anaesth Intensive Care, 2020
van Gastel LHA, Oostdijk EAN, Slot S, Weller D.   +3 more
europepmc   +1 more source

Kaempferol Attenuates Myocardial Ischemia–Reperfusion Injury by Suppressing Ferroptosis via the KEAP1–Nrf2–GPX4 Axis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Myocardial ischemia/reperfusion (I/R) injury is characterized by cardiomyocyte death, excessive oxidative stress, inflammation, and ferroptosis, which collectively limit the efficacy of reperfusion therapy. In this study, we investigated whether kaempferol (KAE), a natural flavonol with antioxidative and antiinflammatory properties, could ...
Yan‐Bo Zhao, Ling‐Ling Sun, Xiao‐Hua Shen, Min Wang, Mei‐Hui Wang, Lu‐Lu Liu, Kai Zhang   +6 more
wiley   +1 more source

A novel alveolar Krebs cycle-triggered CO2 sensing mechanism regulates regional pulmonary ventilation. [PDF]

, 2011
Pulmonary perfusion disorders provoke atelectasis in order to minimize ventilation/perfusion mismatch. However, the underlying mechanisms remain unknown.
Rainer Kiefmann, Martina Kiefmann, Leoni Schulte-Uentrop, Kai Heckel, Oliver Tritt, Sascha Tank, Alwin Goetz, Paula Keller   +7 more
core  

Recent Advances in Exosome‐Based Nanodelivery Systems for Traumatic Brain Injury Treatment

Med Research, EarlyView.
An overview of functional modification, therapeutic effects, molecular composition, and delivery strategies for exosomes. ABSTRACT Traumatic brain injury (TBI) is a highly heterogeneous neurological condition with extremely high rates of mortality and disability.
Jue Zhu, Weiquan Liao, Ziqi Lian, Mengdan Zhang, Chenxing Wang, Xingjia Zhu, Lin Zhang, Jian Chen, Zhichao Lu, Peipei Gong   +9 more
wiley   +1 more source

Role of Fetoscopic Airway Evaluation Immediately Preceding EXIT Procedure in Fetuses With Suspected Airway Obstruction

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective This study describes the role of pre‐EXIT (Ex Utero Intrapartum Treatment) fetoscopic airway evaluation in fetuses with suspected airway obstruction. Methods Single center, retrospective, observational study including fetuses with suspected airway obstruction undergoing fetoscopic airway evaluation prior to EXIT between 2013 and 2025.
Daniel Sanin‐Ramirez, Joan Sabria, Josep M. Martinez, Mar Bennasar, Montserrat Izquierdo, Elisenda Eixarch, Eduard Gratacos   +6 more
wiley   +1 more source

Human Umbilical Cord Mesenchymal Stem Cell‐Derived Microvesicles Alleviate Bronchopulmonary Dysplasia in Preterm Rats by Inhibiting Neutrophil Extracellular Trap Formation

Pediatric Discovery, EarlyView.
Excessive neutrophil extracellular trap (NET) extrusion (NETosis) links prenatal inflammation to bronchopulmonary dysplasia (BPD) pathogenesis. Treatment with human umbilical cord mesenchymal stem cell‐derived microvesicles suppresses NET formation, reduces lung injury, and promotes alveolarization in a preterm rat model, offering a promising cell‐free
Yi Lu, Wen Tan, Xiao Yang, Tingting Luo, Chenghao Mei, Huaqin Bu, Jinhua Ma, Chao Gong, Li Zhong, Ou Zhou, Daiyin Tian   +10 more
wiley   +1 more source

Mechanical ventilation affects alveolar fibrinolysis in LPS-induced lung injury

, 2006
The aim of the present study was to determine the effects of mechanical ventilation on alveolar fibrin turnover in lipopolysaccharide (LPS)-induced lung injury.
Dahlem, P., Lachmann, B., Schultz, MJ, Haitsma, J. J., Dahlem, P, Meijers, JCM, Schultz, M. J., Meijers, J. C.M., Wolthuis, E. K., Bos, A. P., Haitsma, JJ (Jack), Lachmann, BF (Burkhard), Bos, AP (Albert), Meijers, J. C. M., Wolthuis, EK   +14 more
core   +1 more source

Respiratory profile of pediatric patients undergoing hematopoietic stem cell transplantation studied by oscillometry – A TRANSPIRE cohort

Pediatric Investigation, EarlyView.
These are results from a multi‐center collaboration between four large pediatric institutions, investigating baseline respiratory system function in a cohort of children undergoing hematopoietic stem cell transplantation. This manuscript proposes respiratory oscillometry as a novel way to prospectively follow lung function in these children.
Maureen B. Parenti, Julian Allen, Lisa R. Young, Heather Boas, Jason Freedman, Christopher Towe, Jane Koo, Kasiani Myers, Jason C. Woods, Adam Lane, Jonathan Gaffin, Wai Wong, Leslie Lehmann, Fernando Urrego, Gabriel Salinas Cisneros, Matthew F. Abts, K. Scott Baker, Manuel Silva‐Carmona, Erin Doherty, Paul D. Robinson, Margaret MacMillan, Stella M. Davies, Samuel B. Goldfarb   +22 more
wiley   +1 more source