Results 21 to 30 of about 3,803,785 (155)

Calpains play an essential role in mechanical ventilation-induced diaphragmatic weakness and mitochondrial dysfunction

Redox Biology, 2021
Mechanical ventilation (MV) is a life-saving intervention for many critically ill patients. Unfortunately, an unintended consequence of prolonged MV is the rapid development of diaphragmatic atrophy and contractile dysfunction, known as ventilator ...
Hayden W. Hyatt, Mustafa Ozdemir, Toshinori Yoshihara, Branden L. Nguyen, Rafael Deminice, Scott K. Powers   +5 more
doaj   +1 more source

Identifying asynchronies: Early cycling

Journal of Mechanical Ventilation, 2023
Mechanical ventilation is a lifesaving treatment but can be associated with some complications such as ventilator-induced lung injury, ventilator associated pneumonia or ventilation induced diaphragm dysfunction.
Víctor Perez, Jamille Pasco
doaj   +1 more source

Phrenic nerve stimulation prevents diaphragm atrophy in patients with respiratory failure on mechanical ventilation

BMC Pulmonary Medicine, 2021
Background Diaphragm atrophy and dysfunction is a major problem among critically ill patients on mechanical ventilation. Ventilator-induced diaphragmatic dysfunction is thought to play a major role, resulting in a failure of weaning.
Michal Soták, Karel Roubík, Tomáš Henlín, Tomáš Tyll   +3 more
doaj   +1 more source

Intraoperative Hemi-Diaphragm Electrical Stimulation Demonstrates Attenuated Mitochondrial Function without Change in Oxidative Stress in Cardiothoracic Surgery Patients

Antioxidants, 2023
Mechanical ventilation during cardiothoracic surgery is life-saving but can lead to ventilator-induced diaphragm dysfunction (VIDD) and prolong ventilator weaning and hospital length of stay.
Robert T. Mankowski, Stephanie E. Wohlgemuth, Guilherme Bresciani, A. Daniel Martin, George Arnaoutakis, Tomas Martin, Eric Jeng, Leonardo Ferreira, Tiago Machuca, Mindaugas Rackauskas, Ashley J. Smuder, Thomas Beaver, Christiaan Leeuwenburgh, Barbara K. Smith   +13 more
doaj   +1 more source

Early changes in rat diaphragm biology with mechanical ventilation [PDF]

, 2003
To better characterize the effects of 24-hour mechanical ventilation on diaphragm, the expression of myogenic transcription factors, myosin heavy chains, and sarcoplasmic/endoplasmic reticulum calcium-ATPase pumps was examined in rats.
Decramer Marc, De Paepe, Kristel, Testelmans, Dries, Cadot Pascal, Gayan-Ramirez Ghislaine, Rácz, Gábor Z., Wuytack, Frank, Rácz Gábor Z., Zádor, Ernő, Decramer, Marc, Testelmans Dries, Paepe De Kristel, Cadot, Pascal, Zádor Ernő, Wuytack Frank, Gayan-Ramirez, Ghislaine   +15 more
core   +1 more source

Cervical spinal cord injury exacerbates ventilator-induced diaphragm dysfunction

Journal of Applied Physiology, 2016
David Fuller, Kurt Sollanek, Scott Powers   +2 more
exaly   +2 more sources

Ruxolitinib Prevents Ventilator Induced Diaphragm Dysfunction

, 2022
Mechanical ventilation (MV), however brief results in the loss of diaphragm muscle mass and strength, termed ventilator induced diaphragm dysfunction (VIDD).
Larsson, L,, Ruas, J,, Cacciani, N, Cacciani, Nicola,, Moruzzi, Noah,, Larsson, Lars,, Akkad, Hasem,, Addinsall, Alex B.,, Moruzzi, N, Bergquist, J, Addinsall, AB, Akkad, H, Shevchenko, Ganna,, Maestri, A, Shevchenko, G, Ruas, Jorge,, Bergquist, Jonas,, Maestri, Alice,   +17 more
core   +1 more source

Early rehabilitation relieves diaphragm dysfunction induced by prolonged mechanical ventilation: a randomised control study

BMC Pulmonary Medicine, 2021
Background Prolonged mechanical ventilation (MV) induces diaphragm dysfunction in patients in the intensive care units (ICUs). Our study aimed to explore the therapeutic efficacy of early rehabilitation therapy in patients with prolonged MV in the ICU ...
Zehua Dong, Ying Liu, Yubiao Gai, Pingping Meng, Hui Lin, Yuxiao Zhao, Jinyan Xing   +6 more
doaj   +1 more source

Temporary diaphragm pacing for patients at risk of prolonged mechanical ventilation after extensive aortic repair

Journal of Vascular Surgery Cases and Innovative Techniques, 2023
Objective: Prolonged mechanical ventilation (MV) after extensive aortic reconstructive surgery is common. Studies have demonstrated that diaphragm pacing (DP) improves lung function in patients with unilateral diaphragm paralysis.
Jane M. Chung, MD, Aric A. Wogsland, MD, Saideep Bose, MD, Robert Schilz, DO, Raymond P. Onders, MD, Jae S. Cho, MD   +5 more
doaj   +1 more source

Recovery of diaphragm function following mechanical ventilation in a rodent model. [PDF]

PLoS ONE, 2014
BACKGROUND: Mechanical ventilation (MV) induces diaphragmatic muscle fiber atrophy and contractile dysfunction (ventilator induced diaphragmatic dysfunction, VIDD).
Christian S Bruells, Ingmar Bergs, Rolf Rossaint, Jun Du, Christian Bleilevens, Andreas Goetzenich, Joachim Weis, Michael P Wiggs, Scott K Powers, Marc Hein   +9 more
doaj   +1 more source