Results 21 to 30 of about 2,969 (154)

Ventilator-induced diaphragm dysfunction: cause and effect [PDF]

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2013
Mechanical ventilation (MV) is used clinically to maintain gas exchange in patients that require assistance in maintaining adequate alveolar ventilation. Common indications for MV include respiratory failure, heart failure, drug overdose, and surgery.
Scott K, Powers, Michael P, Wiggs, Kurt J, Sollanek, Ashley J, Smuder   +3 more
openaire   +2 more sources

Diaphragm function in patients with Covid-19-related acute respiratory distress syndrome on venovenous extracorporeal membrane oxygenation

Annals of Intensive Care, 2023
Background Venovenous extracorporeal membrane oxygenation (VV ECMO) is frequently associated with deep sedation and neuromuscular blockades, that may lead to diaphragm dysfunction.
Melchior Gautier, Vincent Joussellin, Jacques Ropers, Lina El Houari, Alexandre Demoule, Thomas Similowski, Alain Combes, Matthieu Schmidt, Martin Dres   +8 more
doaj   +1 more source

Calpains play an essential role in mechanical ventilation-induced diaphragmatic weakness and mitochondrial dysfunction

Redox Biology, 2021
Mechanical ventilation (MV) is a life-saving intervention for many critically ill patients. Unfortunately, an unintended consequence of prolonged MV is the rapid development of diaphragmatic atrophy and contractile dysfunction, known as ventilator ...
Hayden W. Hyatt, Mustafa Ozdemir, Toshinori Yoshihara, Branden L. Nguyen, Rafael Deminice, Scott K. Powers   +5 more
doaj   +1 more source

Identifying asynchronies: Early cycling

Journal of Mechanical Ventilation, 2023
Mechanical ventilation is a lifesaving treatment but can be associated with some complications such as ventilator-induced lung injury, ventilator associated pneumonia or ventilation induced diaphragm dysfunction.
Víctor Perez, Jamille Pasco
doaj   +1 more source

Role of intrinsic aerobic capacity and ventilator-induced diaphragm dysfunction.

J Appl Physiol (1985), 2015
Prolonged mechanical ventilation (MV) leads to rapid diaphragmatic atrophy and contractile dysfunction, which is collectively termed “ventilator-induced diaphragm dysfunction” (VIDD). Interestingly, endurance exercise training prior to MV has been shown to protect against VIDD.
Sollanek KJ, Smuder AJ, Wiggs MP, Morton AB, Koch LG, Britton SL, Powers SK.   +6 more
europepmc   +4 more sources

Phrenic nerve stimulation prevents diaphragm atrophy in patients with respiratory failure on mechanical ventilation

BMC Pulmonary Medicine, 2021
Background Diaphragm atrophy and dysfunction is a major problem among critically ill patients on mechanical ventilation. Ventilator-induced diaphragmatic dysfunction is thought to play a major role, resulting in a failure of weaning.
Michal Soták, Karel Roubík, Tomáš Henlín, Tomáš Tyll   +3 more
doaj   +1 more source

Intraoperative Hemi-Diaphragm Electrical Stimulation Demonstrates Attenuated Mitochondrial Function without Change in Oxidative Stress in Cardiothoracic Surgery Patients

Antioxidants, 2023
Mechanical ventilation during cardiothoracic surgery is life-saving but can lead to ventilator-induced diaphragm dysfunction (VIDD) and prolong ventilator weaning and hospital length of stay.
Robert T. Mankowski, Stephanie E. Wohlgemuth, Guilherme Bresciani, A. Daniel Martin, George Arnaoutakis, Tomas Martin, Eric Jeng, Leonardo Ferreira, Tiago Machuca, Mindaugas Rackauskas, Ashley J. Smuder, Thomas Beaver, Christiaan Leeuwenburgh, Barbara K. Smith   +13 more
doaj   +1 more source

Leupeptin Inhibits Ventilator-induced Diaphragm Dysfunction in Rats [PDF]

American Journal of Respiratory and Critical Care Medicine, 2007
Abstract Rationale Controlled mechanical ventilation (CMV) has been shown to result in elevated diaphragmatic proteolysis and atrophy together with diaphragmatic contractile dysfunction. Objectives To test whether ...
Karen, Maes, Dries, Testelmans, Scott, Powers, Marc, Decramer, Ghislaine, Gayan-Ramirez   +4 more
openaire   +2 more sources

Bortezomib partially protects the rat diaphragm from ventilator-induced diaphragm dysfunction* [PDF]

Critical Care Medicine, 2012
Controlled mechanical ventilation leads to diaphragmatic contractile dysfunction and atrophy. Since proteolysis is enhanced in the diaphragm during controlled mechanical ventilation, we examined whether the administration of a proteasome inhibitor, bortezomib, would have a protective effect against ventilator-induced diaphragm dysfunction.Randomized ...
Agten, A., Maes, K., Thomas, D, Cielen, N., Hees, H.W. van, Dekhuijzen, R., Decramer, M., Gayan-Ramirez, G.   +7 more
openaire   +4 more sources

Endurance exercise attenuates ventilator-induced diaphragm dysfunction.

J Appl Physiol (1985), 2012
Controlled mechanical ventilation (MV) is a life-saving measure for patients in respiratory failure. However, MV renders the diaphragm inactive leading to diaphragm weakness due to both atrophy and contractile dysfunction. It is now established that oxidative stress is a requirement for MV-induced diaphragmatic proteolysis, atrophy, and contractile ...
Smuder AJ, Min K, Hudson MB, Kavazis AN, Kwon OS, Nelson WB, Powers SK.   +6 more
europepmc   +4 more sources