Results 31 to 40 of about 2,969 (154)

Hypercapnia attenuates ventilator-induced diaphragm atrophy and modulates dysfunction [PDF]

Critical Care, 2014
Abstract Introduction Diaphragm weakness induced by prolonged mechanical ventilation may contribute to difficult weaning from the ventilator. Hypercapnia is an accepted side effect of low tidal volume mechanical ventilation, but the effects of hypercapnia on respiratory muscle function are largely unknown.
Schellekens, W.J.M., van Hees, H.W.H., Kox, M., Kox, M., Linkels, M., Acuna, G.L., Dekhuijzen, P.N.R., Scheffer, G.J., van der Hoeven, J.G., van der Hoeven, J.G., Heunks, L.M.A.   +10 more
openaire   +5 more sources

Early rehabilitation relieves diaphragm dysfunction induced by prolonged mechanical ventilation: a randomised control study

BMC Pulmonary Medicine, 2021
Background Prolonged mechanical ventilation (MV) induces diaphragm dysfunction in patients in the intensive care units (ICUs). Our study aimed to explore the therapeutic efficacy of early rehabilitation therapy in patients with prolonged MV in the ICU ...
Zehua Dong, Ying Liu, Yubiao Gai, Pingping Meng, Hui Lin, Yuxiao Zhao, Jinyan Xing   +6 more
doaj   +1 more source

Temporary diaphragm pacing for patients at risk of prolonged mechanical ventilation after extensive aortic repair

Journal of Vascular Surgery Cases and Innovative Techniques, 2023
Objective: Prolonged mechanical ventilation (MV) after extensive aortic reconstructive surgery is common. Studies have demonstrated that diaphragm pacing (DP) improves lung function in patients with unilateral diaphragm paralysis.
Jane M. Chung, MD, Aric A. Wogsland, MD, Saideep Bose, MD, Robert Schilz, DO, Raymond P. Onders, MD, Jae S. Cho, MD   +5 more
doaj   +1 more source

Recovery of diaphragm function following mechanical ventilation in a rodent model. [PDF]

PLoS ONE, 2014
BACKGROUND: Mechanical ventilation (MV) induces diaphragmatic muscle fiber atrophy and contractile dysfunction (ventilator induced diaphragmatic dysfunction, VIDD).
Christian S Bruells, Ingmar Bergs, Rolf Rossaint, Jun Du, Christian Bleilevens, Andreas Goetzenich, Joachim Weis, Michael P Wiggs, Scott K Powers, Marc Hein   +9 more
doaj   +1 more source

Diaphragm muscle weakness in an experimental porcine intensive care unit model.

PLoS ONE, 2011
In critically ill patients, mechanisms underlying diaphragm muscle remodeling and resultant dysfunction contributing to weaning failure remain unclear. Ventilator-induced modifications as well as sepsis and administration of pharmacological agents such ...
Julien Ochala, Guillaume Renaud, Monica Llano Diez, Varuna C Banduseela, Sudhakar Aare, Karsten Ahlbeck, Peter J Radell, Lars I Eriksson, Lars Larsson   +8 more
doaj   +1 more source

First non-invasive magnetic phrenic nerve and diaphragm stimulation in anaesthetized patients: a proof-of-concept study

Intensive Care Medicine Experimental, 2023
Background Mechanical ventilation has side effects such as ventilator-induced diaphragm dysfunction, resulting in prolonged intensive care unit length of stays.
Alessandro Panelli, Hermann Georges Bartels, Sven Krause, Michael André Verfuß, Aline Michèle Grimm, Niklas Martin Carbon, Julius J. Grunow, Diego Stutzer, Thomas Niederhauser, Laurent Brochard, Steffen Weber-Carstens, Stefan J. Schaller   +11 more
doaj   +1 more source

Lung-protective ventilation worsens ventilator-induced diaphragm atrophy and weakness

Respiratory Research, 2020
Background Lung–protective ventilation (LPV) has been found to minimize the risk of ventilator–induced lung injury (VILI). However, whether LPV is able to diminish ventilator–induced diaphragm dysfunction (VIDD) remains unknown.
Xian-Long Zhou, Xiao-Jun Wei, Shao-Ping Li, Hao-Li Ma, Yan Zhao   +4 more
doaj   +1 more source

Disturbances in Calcium Homeostasis Promotes Skeletal Muscle Atrophy: Lessons From Ventilator-Induced Diaphragm Wasting

Frontiers in Physiology, 2020
Mechanical ventilation (MV) is often a life-saving intervention for patients in respiratory failure. Unfortunately, a common and undesired consequence of prolonged MV is the development of diaphragmatic atrophy and contractile dysfunction.
Hayden W. Hyatt, Scott K. Powers
doaj   +1 more source

N‐acetylcysteine attenuates ventilator‐induced diaphragm dysfunction in rats [PDF]

The FASEB Journal, 2010
Controlled mechanical ventilation (CMV) results in diaphragmatic dysfunction and oxidative stress. We examined whether an anti‐oxidant, N‐acetylcysteine (NAC), would restore the redox‐balance in the diaphragm and prevent the deleterious effects of CMV.
Anouk Agten, Karen Maes, Ashley Smuder, Scott K Powers, Marc Decramer, Ghislaine Gayan‐Ramirez   +5 more
openaire   +2 more sources

Endoplasmic Reticulum Stress Contributes to Ventilator-Induced Diaphragm Atrophy and Weakness in Rats

Frontiers in Physiology, 2022
Background: Accumulating evidence indicates that endoplasmic reticulum (ER) stress plays a critical role in the regulation of skeletal muscle mass. In recent years, much attention has been given to ventilator-induced diaphragm dysfunction (VIDD) because ...
Shaoping Li, Guanguan Luo, Rong Zeng, Lian Lin, Xingnan Zou, Yu Yan, Haoli Ma, Jian Xia, Yan Zhao, Xianlong Zhou   +9 more
doaj   +1 more source