Results 31 to 40 of about 3,803,785 (155)

Diaphragm muscle weakness in an experimental porcine intensive care unit model.

PLoS ONE, 2011
In critically ill patients, mechanisms underlying diaphragm muscle remodeling and resultant dysfunction contributing to weaning failure remain unclear. Ventilator-induced modifications as well as sepsis and administration of pharmacological agents such ...
Julien Ochala, Guillaume Renaud, Monica Llano Diez, Varuna C Banduseela, Sudhakar Aare, Karsten Ahlbeck, Peter J Radell, Lars I Eriksson, Lars Larsson   +8 more
doaj   +1 more source

First non-invasive magnetic phrenic nerve and diaphragm stimulation in anaesthetized patients: a proof-of-concept study

Intensive Care Medicine Experimental, 2023
Background Mechanical ventilation has side effects such as ventilator-induced diaphragm dysfunction, resulting in prolonged intensive care unit length of stays.
Alessandro Panelli, Hermann Georges Bartels, Sven Krause, Michael André Verfuß, Aline Michèle Grimm, Niklas Martin Carbon, Julius J. Grunow, Diego Stutzer, Thomas Niederhauser, Laurent Brochard, Steffen Weber-Carstens, Stefan J. Schaller   +11 more
doaj   +1 more source

Hypercapnia attenuates ventilator-induced diaphragm atrophy and modulates dysfunction [PDF]

, 2014
Contains fulltext : 134064.pdf (Publisher’s version ) (Open Access)INTRODUCTION: Diaphragm weakness induced by prolonged mechanical ventilation may contribute to difficult weaning from the ventilator.
Leo MA Heunks, Gilberto L Acuña, Dekhuijzen, P.N.R., Hoeven, J.G. van der, Heunks, L.M.A., Marianne Linkels, Johannes G van der Hoeven, Linkels, M., Scheffer, Gert J., van der Hoeven, Johannes G., Matthijs Kox, PN Dekhuijzen, van Hees, Hieronymus W.H., Dekhuijzen, PN N.R., Heunks, Leo M.A., Gert Scheffer, Kox, Matthijs, Acuña, Gilberto L.A., Hees, H.W.H. van, Kox, M., Schellekens, W.J.M., Schellekens, Willem Jan M., Linkels, Marianne, Scheffer, G.J., Acuna, G.L., Hieronymus WH van Hees, Willem-Jan M Schellekens   +26 more
core   +2 more sources

Lung-protective ventilation worsens ventilator-induced diaphragm atrophy and weakness

Respiratory Research, 2020
Background Lung–protective ventilation (LPV) has been found to minimize the risk of ventilator–induced lung injury (VILI). However, whether LPV is able to diminish ventilator–induced diaphragm dysfunction (VIDD) remains unknown.
Xian-Long Zhou, Xiao-Jun Wei, Shao-Ping Li, Hao-Li Ma, Yan Zhao   +4 more
doaj   +1 more source

Disturbances in Calcium Homeostasis Promotes Skeletal Muscle Atrophy: Lessons From Ventilator-Induced Diaphragm Wasting

Frontiers in Physiology, 2020
Mechanical ventilation (MV) is often a life-saving intervention for patients in respiratory failure. Unfortunately, a common and undesired consequence of prolonged MV is the development of diaphragmatic atrophy and contractile dysfunction.
Hayden W. Hyatt, Scott K. Powers
doaj   +1 more source

The role of calpains in ventilator-induced diaphragm atrophy [PDF]

, 2017
Contains fulltext : 178017.pdf (Publisher’s version ) (Open Access)BACKGROUND: Controlled mechanical ventilation (CMV) is associated with diaphragm dysfunction.
Jiaru Huang, Heunks, Leo, Hees, H.W.H. van, Huang, Jiaru, van Hees, Hieronymus W H, Ma, Shaolin, Lei Shi, Shaolin Ma, Wang, F, Leo Heunks, Shi, L., Ma, S., Shao, Lei, Lei Shao, Zhu, Xiaoping, Xiaoping Zhu, Hieronymus W. H. van Hees, Feifei Wang, Shao, L., Heunks, L.M., Wang, Feifei, Shi, Lei, Zhu, X, Huang, J.   +23 more
core   +3 more sources

Endoplasmic Reticulum Stress Contributes to Ventilator-Induced Diaphragm Atrophy and Weakness in Rats

Frontiers in Physiology, 2022
Background: Accumulating evidence indicates that endoplasmic reticulum (ER) stress plays a critical role in the regulation of skeletal muscle mass. In recent years, much attention has been given to ventilator-induced diaphragm dysfunction (VIDD) because ...
Shaoping Li, Guanguan Luo, Rong Zeng, Lian Lin, Xingnan Zou, Yu Yan, Haoli Ma, Jian Xia, Yan Zhao, Xianlong Zhou   +9 more
doaj   +1 more source

Electrical stimulation mitigates muscle degradation shift in gene expressions during 12-h mechanical ventilation

Scientific Reports, 2023
Ventilator-induced diaphragm dysfunction (VIDD), a dysfunction of the diaphragm muscle caused by prolonged mechanical ventilation (MV), is an important factor that hinders successful weaning from ventilation.
Hideki Nakai, Yutaka Hirata, Hidemasa Furue, Yoshitaka Oku   +3 more
doaj   +1 more source

Hemorrhagic Shock Sensitized the Diaphragm to Ventilator-Induced Dysfunction through the Activation of IL-6/JAK/STAT Signaling-Mediated Autophagy in Rats

Mediators of Inflammation, 2019
Mechanical ventilation (MV) is a major life support technique for the management of trauma-associated hemorrhagic shock (HS). Ventilator-induced diaphragm dysfunction (VIDD), one of the most common complications of MV, has been well demonstrated in ...
Li-Juan Zhang, Shao-Zhou Ni, Xian-Long Zhou, Yan Zhao   +3 more
doaj   +1 more source

Late Ventilator-Induced Diaphragmatic Dysfunction After Extubation

, 2020
International audienceObjectives: Mechanical ventilation is associated with primary diaphragmatic dysfunction, also termed ventilator-induced diaphragmatic dysfunction. Studies evaluating diaphragmatic function recovery after extubation are lacking.
Yehya, Mohamad, Marks, Andrew, Boris Jung, Steven Reiken, Jung, Boris, Daurat, Aurelien, Andrew R. Marks, Alain Lacampagne, Lacampagne, Alain, Reiken, Steven, Jaber, Samir, Dridi, Haikel, Mohamad Yehya, Samir Jaber, Haikel Dridi, Aurelien Daurat, Matecki, Stefan, Stefan Matecki, Moreau, Johan, Johan Moreau   +19 more
core   +1 more source