Results 51 to 60 of about 2,969 (154)

Ventilator-induced diaphragm dysfunction: time for (contr)action! [PDF]

European Respiratory Journal, 2013
During the past 10 years, intensive experimental research has focused on the effects of mechanical ventilation on the diaphragm. Whatever the animal species studied, all these studies have consistently shown that mechanical ventilation impaired diaphragm function, resulting in the so-called ventilator-induced diaphragm dysfunction (VIDD) [1–9].
openaire   +2 more sources

Characterisation of sleep apneas and respiratory circuitry in mice lacking CDKL5

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary CDKL5 deficiency disorder is a rare genetic disease caused by mutations in the CDKL5 gene. Central apneas during wakefulness have been reported in patients with CDKL5 deficiency disorder. Studies on CDKL5‐knockout mice, a CDKL5 deficiency disorder model, reported sleep apneas, but it is still unclear whether these events are central (central ...
Gabriele Matteoli, Sara Alvente, Stefano Bastianini, Chiara Berteotti, Elisabetta Ciani, Elenia Cinelli, Viviana Lo Martire, Giorgio Medici, Tommaso Mello, Elena Miglioranza, Alessandro Silvani, Donatella Mutolo, Giovanna Zoccoli   +12 more
wiley   +1 more source

The Association of Sarcopenic Obesity With Respiratory Function Outcomes in Adults: A Systematic Review and Meta‐Analysis

Obesity Reviews, EarlyView.
ABSTRACT Sarcopenic obesity has been associated with various health conditions and mortality. Our objective was to systematically review and estimate the association between sarcopenic obesity and respiratory function outcomes. We searched EMBASE, MEDLINE, and Google Scholar for observational studies involving adults (≥ 18 years), defined sarcopenic ...
Tasneem Baabbad, Magaly Aceves‐Martins, Graham Horgan, Phyo Kyaw Myint, Baukje de Roos   +4 more
wiley   +1 more source

Time course analysis of mechanical ventilation‐induced diaphragm contractile muscle dysfunction in the rat [PDF]

The Journal of Physiology, 2014
Key points Weaning from mechanical ventilation (MV) of long‐term intensive care unit (ICU) patients is delayed by impaired respiratory muscle function; however, the mechanisms that cause the impairment are not fully understood. A novel experimental rat ICU model was used for time‐resolved analyses (6 h to 2 weeks) of the effects of MV on diaphragm ...
Corpeno R, Dworkin B, Cacciani N, Salah H, Bergman HM, RAVARA, BARBARA, Vitadello M, GORZA, LUISA, Gustafson AM, Hedström Y, Petersson J, Feng HZ, Jin JP, Iwamoto H, Yagi N, Artemenko K, Bergquist J, Larsson L.   +17 more
openaire   +4 more sources

Retrospective Analysis of Survival and Adverse Effects Associated With Stereotactic Body Radiation Therapy in 12 Dogs With Hepatocellular Carcinoma

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT This retrospective analysis evaluated 12 dogs with hepatocellular carcinoma (HCC) who received stereotactic body radiation therapy (SBRT). Dogs received between 6 and 25 Grey (Gy) per fraction for 1–5 fractions for a total dose of 13–30 Gy. Eleven patients (92%) experienced acute adverse effects (AE), with the majority being VRTOG grade 2–3 ...
Victoria Lee Newberry, Mary‐Keara Boss, Del Leary, Tiffany W. Martin   +3 more
wiley   +1 more source

Temporary caval occlusion technique during right divisional hepatectomy for massive hepatocellular carcinoma with caudal vena cava compression/involvement in dogs

Veterinary Surgery, EarlyView.
Abstract Objective To describe the perioperative and long‐term outcomes of dogs with massive hepatocellular carcinoma (HCC) in the right hepatic division causing compression or involvement of the caudal vena cava (CVC) treated with right divisional hepatectomy using temporary caval occlusion (TCO). Study design Retrospective case series.
Kumiko Ishigaki, Kazushi Asano, Kei Tamura, Tatsuya Heishima, Takeshi Hayakawa, Teppei Fujimoto, Kenji Teshima   +6 more
wiley   +1 more source

Bortezomib partially protects the rat diaphragm from ventilator‐induced diaphragm dysfunction

The FASEB Journal, 2011
Controlled mechanical ventilation leads to diaphragmatic contractile dysfunction and atrophy. Since proteolysis is enhanced in the diaphragm during controlled mechanical ventilation, we examined whether the administration of a proteasome inhibitor, Bortezomib, would have a protective effect against ventilator‐induced diaphragm dysfunction.
Anouk Agten, Karen Maes, Debby Thomas, Marc Decramer, Ghislaine Gayan‐Ramirez   +4 more
openaire   +1 more source

MRI Assessment of Global and Regional Diaphragmatic Motion in Critically Ill Patients Following Prolonged Ventilator Weaning

Medical Sciences, 2019
Introduction: diaphragmatic dysfunction is a common cause of slow weaning in mechanically ventilated patients. Diaphragmatic dysfunction in ventilated patients can be global or regional.
Khurram Saleem Khan, James Meaney, Ignacio Martin-Loeches, Daniel V. Collins   +3 more
doaj   +1 more source

Applying lessons from limb muscle disuse and ageing to better understand ventilator‐induced diaphragm dysfunction

Experimental Physiology, EarlyView.
Abstract Mechanical ventilation (MV) is a life‐saving intervention applied to critically ill patients. A common consequence of MV is ventilator‐induced diaphragm dysfunction (VIDD), which is characterized by significant diaphragm atrophy and reduced contractile function. Older patients who receive MV are more likely to develop VIDD, have worse recovery,
P. H. C. Mesquita, J. L. Halle, J. D. Fuqua, B. F. Miller   +3 more
wiley   +1 more source

Haemodynamic responses to head‐up tilt versus lower‐body negative pressure in type 1 diabetes

Experimental Physiology, EarlyView.
Abstract Head‐up tilt (HUT) and lower‐body negative pressure (LBNP) both reduce central blood volume but differ in heart orientation and regional fluid shifts. Whether they evoke comparable cardiovascular regulation when matched for preload remains uncertain.
Victorien Faivre‐Rampant, Jules Warnier, Perrine Larmet, Damien Garcia, Michael Joubert, Damian Miles Bailey, Igor Mekjavic, Hervé Normand, Amir Hodzic   +8 more
wiley   +1 more source