Results 71 to 80 of about 2,969 (154)

Intraoperative hemidiaphragm electrical stimulation reduces oxidative stress and upregulates autophagy in surgery patients undergoing mechanical ventilation: exploratory study

Journal of Translational Medicine, 2016
Background Mechanical ventilation (MV) during a cardio-thoracic surgery contributes to diaphragm muscle dysfunction that impairs weaning and can lead to the ventilator- induced diaphragm dysfunction.
Robert T. Mankowski, Shakeel Ahmed, Thomas Beaver, Marvin Dirain, Chul Han, Phillip Hess, Tomas Martin, Barbara K. Smith, Shinichi Someya, Christiaan Leeuwenburgh, A. Daniel Martin   +10 more
doaj   +1 more source

Mechanism of Action and Therapeutic Potential of Sulforaphane in Skeletal Muscle Diseases: Molecular Pathways and Precision Medicine

Food Science &Nutrition, Volume 14, Issue 7, July 2026.
Sulforaphane modulates mTOR, Nrf2, NF‐κB, and AMPK/PGC‐1α pathways to protect skeletal muscle and enable precision‐medicine intervention in ICU‐acquired weakness, sarcopenia, and diabetic myopathy. ABSTRACT Sulforaphane (SFN), a bioactive isothiocyanate abundant in cruciferous vegetables, has attracted growing interest as a potential nutraceutical ...
Minru Zhao, Bo Huang, Juan Chen, Junya Li, Zhongli Zhu, Guoyun Zhu, Jian Hu, Fuxiang Li, Jian Feng   +8 more
wiley   +1 more source

Asynchrony Related to Mechanical Ventilation Exacerbates Diaphragm Dysfunction in a Mouse Model of Duchenne Muscular Dystrophy

Muscle &Nerve, Volume 74, Issue 1, Page 255-264, July 2026.
ABSTRACT Introduction/Aims In dystrophic mice (mdx, a genetic homolog of Duchenne muscular dystrophy: DMD), previous studies showed that mechanical ventilation (MV) induces ventilator‐induced diaphragmatic dysfunction (VIDD). However, susceptibility to mechanical stress caused by asynchrony remains unknown.
Mohamad Yehya, Haikel Dridi, Eric Estève, Johan Moreau, Steven Reiken, Andrew R. Marks, Alain Lacampagne, Stefan Matecki   +7 more
wiley   +1 more source

Diaphragm ultrasound as a new functional and morphological index of outcome, prognosis and discontinuation from mechanical ventilation in critically ill patients and evaluating the possible protective indices against VIDD

Egyptian Journal of Chest Disease and Tuberculosis, 2017
Background: There is increasing awareness that diaphragm weakness is common in patients undergoing MV and is likely a contributing cause of weaning failure.
Eman Ramzy Ali, Ahmad Mostafa Mohamad
doaj   +1 more source

New perspectives on the physiological basis of muscle loss

Experimental Physiology, EarlyView.
Alistair J. Monteyne, Marlou L. Dirks
wiley   +1 more source

Glucagon‐Like Peptide‐1 Agonist vs. Placebo and Pulmonary Decline After Open‐Heart Surgery: A Substudy of the GLORIOUS Randomised Clinical Trial

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 6, July 2026.
ABSTRACT Background Postoperative pulmonary decline is an established complication of open‐heart surgery extending beyond the immediate postoperative phase. Inflammation‐mediated lung damage and ischaemia‐reperfusion injury secondary to extracorporeal circulation is a proposed pathophysiological driver. GLP‐1 receptor agonists (GLP‐1RA) have emerged as
Astrid Duus Mikkelsen, Sebastian Wiberg, Hans Henrik Lawaetz Schultz, Peter Hasse Møller‐Sørensen, Dan Høfsten, Jens Christian Nilsson, Christian Holdflod Møller, Lars Køber, Christian Hassager, Jesper Kjærgaard   +9 more
wiley   +1 more source

Reliability of ultrasonic diaphragm thickness measurement in mechanically ventilated infants and children: A pilot study

Southern African Journal of Critical Care, 2018
Background. Diaphragmatic atrophy in mechanically ventilated infants and children may be due to ventilator-induced diaphragmatic dysfunction, which could lead to extubation failure.
M Terhart, S Hanekom, A Lupton-Smith, B Morrow   +3 more
doaj  

Recent Advances in Pediatric Ventilatory Assistance [version 1; referees: 2 approved]

F1000Research, 2017
In this review on respiratory assistance, we aim to discuss the following recent advances: the optimization and customization of mechanical ventilation, the use of high-frequency oscillatory ventilation, and the role of noninvasive ventilation.
Nicolas Nardi, Guillaume Mortamet, Laurence Ducharme-Crevier, Guillaume Emeriaud, Philippe Jouvet   +4 more
doaj   +1 more source

Ultrasound assessment of diaphragmatic dysfunction in non-critically ill patients: relevant indicators and update

Frontiers in Medicine
Diaphragm dysfunction (DD) can be classified as mild, resulting in diaphragmatic weakness, or severe, resulting in diaphragmatic paralysis. Various factors such as prolonged mechanical ventilation, surgical trauma, and inflammation can cause ...
Xin-Yu Yao, Xin-Yu Yao, Hong-Mei Li, Hong-Mei Li, Bo-Wen Sun, Bo-Wen Sun, Ying-Ying Zhang, Ying-Ying Zhang, Jian-Guo Feng, Jian-Guo Feng, Jing Jia, Jing Jia, Li Liu, Li Liu   +13 more
doaj   +1 more source

Temporary transvenous diaphragm pacing vs. standard of care for weaning from mechanical ventilation: study protocol for a randomized trial

Trials, 2019
Background Mechanical ventilation (MV) is a life-saving technology that restores or assists breathing. Like any treatment, MV has side effects. In some patients it can cause diaphragmatic atrophy, injury, and dysfunction (ventilator-induced diaphragmatic
Douglas Evans, Deborah Shure, Linda Clark, Gerard J. Criner, Martin Dres, Marcelo Gama de Abreu, Franco Laghi, David McDonagh, Basil Petrof, Teresa Nelson, Thomas Similowski   +10 more
doaj   +1 more source