Results 71 to 80 of about 3,803,785 (155)

Haemodynamic responses to head‐up tilt versus lower‐body negative pressure in type 1 diabetes

Experimental Physiology, Volume 111, Issue 9, Page 4089-4102, 1 September 2026.
Abstract Head‐up tilt (HUT) and lower‐body negative pressure (LBNP) both reduce central blood volume but differ in heart orientation and regional fluid shifts. Whether they evoke comparable cardiovascular regulation when matched for preload remains uncertain.
Victorien Faivre‐Rampant, Jules Warnier, Perrine Larmet, Damien Garcia, Michael Joubert, Damian Miles Bailey, Igor Mekjavic, Hervé Normand, Amir Hodzic   +8 more
wiley   +1 more source

Intraoperative hemidiaphragm electrical stimulation reduces oxidative stress and upregulates autophagy in surgery patients undergoing mechanical ventilation: exploratory study

Journal of Translational Medicine, 2016
Background Mechanical ventilation (MV) during a cardio-thoracic surgery contributes to diaphragm muscle dysfunction that impairs weaning and can lead to the ventilator- induced diaphragm dysfunction.
Robert T. Mankowski, Shakeel Ahmed, Thomas Beaver, Marvin Dirain, Chul Han, Phillip Hess, Tomas Martin, Barbara K. Smith, Shinichi Someya, Christiaan Leeuwenburgh, A. Daniel Martin   +10 more
doaj   +1 more source

Long‐term imoxin treatment does not attenuate disease severity in dystrophic diaphragm of male mice

Physiological Reports, Volume 14, Issue 18, September 2026.
Abstract Duchenne muscular dystrophy (DMD) is characterized by chronic skeletal muscle injury and degeneration. We discovered activation of protein kinase R (PKR; EIF2AK2), a regulator of the integrated stress response, in dystrophic muscle; however, its role in DMD remains unknown.
Ji Heun Lee, Morgan E. Vorwald, Melissa Roths, Joshua T. Selsby, Rudy J. Valentine   +4 more
wiley   +1 more source

Ventilator-induced diaphragmatic dysfunction in MDX mice

, 2017
International audienceIntroduction: Patients with Duchenne muscular dystrophy (DMD) frequently undergo mechanical ventilation (MV) for treatment of hypoventilation, but the susceptibility of the dystrophic diaphragm to ventilator‐induced diaphragmatic ...
Giordano, Christian, Li, Tong, Liang, Feng, Matecki, Stéfan, Feng Liang, Petrof, Basil, Han Liang, Christian Giordano, Hussain, Sabah, Basil J. Petrof, Liang, Han, Tong Li, Azuelos, Ilan, Ilan Azuelos, Sabah N. Hussain, Stefan Matecki   +15 more
core   +1 more source

Changes in Muscle Mass and Quality Mediate the Effect of High‐Calorie Intake on Clinical Outcomes

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 4, August 2026.
ABSTRACT Background Critically ill patients frequently experienced acquired muscle dysfunction, which adversely affects outcomes. The relationship between calorie intake, muscle dysfunction and outcomes remains unclear. This study aims to determine if early calorie intake affects patients' outcomes through changes in skeletal muscle mass or quality ...
Yassir Aarab, Fabrice Raynaud, Mathieu Capdevila, Aurelien Flatres, Gérald Hugon, Céline Lauret, Nicolas Molinari, Celia Vidal, Kada Klouche, Samir Jaber, Stefan Matecki, Boris Jung   +11 more
wiley   +1 more source

Supplementary Material for: State-of-the-Art Opinion Article on Ventilator-Induced Diaphragm Dysfunction: Update on Diagnosis, Clinical Course, and Future Treatment Options

, 2023
Evidence from both animal and human studies now supports the development of ventilator-induced diaphragm dysfunction (VIDD) starting as early as 24 h after initiation of mechanical ventilation in the intensive care unit (ICU).
Spiesshoefer J. (7139138), Kersten A. (4148467), Regmi B. (14201651), Dreher M. (5450342), EnriquezGeppert J. (14201648), Senol M. (14201654), Kabitz H.J. (8831252)   +6 more
core   +1 more source

Diaphragm ultrasound as a new functional and morphological index of outcome, prognosis and discontinuation from mechanical ventilation in critically ill patients and evaluating the possible protective indices against VIDD

Egyptian Journal of Chest Disease and Tuberculosis, 2017
Background: There is increasing awareness that diaphragm weakness is common in patients undergoing MV and is likely a contributing cause of weaning failure.
Eman Ramzy Ali, Ahmad Mostafa Mohamad
doaj   +1 more source

Ruxolitinib : A new hope for ventilator-induced diaphragm dysfunction

Aim: Mechanical ventilation (MV) results in diminished diaphragm size and strength, termed ventilator-induced diaphragm dysfunction (VIDD). VID increases dependence, prolongs weaning, and increases discharge mortality rates. The Janus kinase (JAK)/Signal
Cacciani, Nicola, Widgren, Anna, Berggren, Per-Olof, Larsson, Lars, Tchkonia, Tamara, Akkad, Hazem, Bergquist, Jonas, Addinsall, Alex B., Kirkland, James L., Maestri, Alice, Moruzzi, Noah   +10 more
core   +1 more source

Rapid Onset of Specific Diaphragm Weakness in a Healthy Murine Model of Ventilator-induced Diaphragmatic Dysfunction

, 2012
International audienceBackground: Controlled mechanical ventilation is associated with ventilator-induced diaphragmatic dysfunction, which impedes weaning from mechanical ventilation.
Constantin, Jean Michel, Jung, Boris, Petrof, Basil, Pauly, Marion, Roberge, Stéphanie, Futier, Emmanuel, Lacampagne, Alain, Cassan, Cécile, Jaber, Samir, Molinari, Nicolas, Mrozek, Ségolène, Thireau, Jérôme, Scheuermann, Valérie, Matecki, Stefan   +13 more
core   +1 more source

Reliability of ultrasonic diaphragm thickness measurement in mechanically ventilated infants and children: A pilot study

Southern African Journal of Critical Care, 2018
Background. Diaphragmatic atrophy in mechanically ventilated infants and children may be due to ventilator-induced diaphragmatic dysfunction, which could lead to extubation failure.
M Terhart, S Hanekom, A Lupton-Smith, B Morrow   +3 more
doaj