Results 61 to 70 of about 2,969 (154)

Inhibition of Forkhead BoxO–Specific Transcription Prevents Mechanical Ventilation–Induced Diaphragm Dysfunction [PDF]

Critical Care Medicine, 2015
Mechanical ventilation is a lifesaving measure for patients with respiratory failure. However, prolonged mechanical ventilation results in diaphragm weakness, which contributes to problems in weaning from the ventilator. Therefore, identifying the signaling pathways responsible for mechanical ventilation-induced diaphragm weakness is essential to ...
Ashley J, Smuder, Kurt J, Sollanek, Kisuk, Min, W Bradley, Nelson, Scott K, Powers   +4 more
openaire   +2 more sources

Cannabinoid exposure during pregnancy: Cardiorespiratory effects and offspring outcomes

The Journal of Physiology, EarlyView.
Abstract figure legend Prenatal exposure to cannabinoids has been investigated across human and animal studies to understand its impact on physiological development. Evidence suggests that early‐life cannabinoid exposure influence multiple developmental processes, extending beyond neurodevelopmental outcomes to potentially affect placental function ...
Luis Gustavo A. Patrone, Luciane H. Gargaglioni   +1 more
wiley   +1 more source

Mechanical ventilation causes diaphragm dysfunction in newborn lambs

Critical Care, 2019
Background Diaphragm weakness occurs rapidly in adult animals treated with mechanical ventilation (MV), but the effects of MV on the neonatal diaphragm have not been determined.
Feng Liang, Guillaume Emeriaud, Dilson E. Rassier, Dong Shang, Ekaterina Gusev, Sabah N. A. Hussain, Michael Sage, Benjamin Crulli, Etienne Fortin-Pellerin, Jean-Paul Praud, Basil J. Petrof   +10 more
doaj   +1 more source

Feasibility of transesophageal phrenic nerve stimulation

BioMedical Engineering OnLine, 2023
Background Every year, more than 2.5 million critically ill patients in the ICU are dependent on mechanical ventilation. The positive pressure in the lungs generated by the ventilator keeps the diaphragm passive, which can lead to a loss of myofibers ...
Elisa M. Kaufmann, Sven Krause, Lukas Geisshuesler, Olivier Scheidegger, Andreas Haeberlin, Thomas Niederhauser   +5 more
doaj   +1 more source

Obstructive Sleep Apnea: Epidemiology, Pathophysiology, Complications, Diagnosis, Management, and Emerging Fibrosis‐Linked Remodeling

MedComm, Volume 7, Issue 8, August 2026.
Obstructive sleep apnea (OSA) is characterized by recurrent upper‐airway collapse, which generates key nocturnal stressors including intermittent hypoxia, sleep fragmentation, intrathoracic pressure stress, and sympathetic activation. These physiological disturbances converge on shared biological mechanisms, including oxidative stress, inflammation ...
Nhi Ho Thi Thuy, Thị Hằng Giang Phan, Ali Hussein Eid, Paola Maccioccu, Stefania Camboni, Gavino Casu, Anna Maria Posadino, Roberta Giordo, Gianfranco Pintus   +8 more
wiley   +1 more source

Neurally adjusted ventilatory assist mitigates ventilator-induced diaphragm injury in rabbits

Respiratory Research, 2019
Background Ventilator-induced diaphragmatic dysfunction is a serious complication associated with higher ICU mortality, prolonged mechanical ventilation, and unsuccessful withdrawal from mechanical ventilation.
Tatsutoshi Shimatani, Nobuaki Shime, Tomohiko Nakamura, Shinichiro Ohshimo, Justin Hotz, Robinder G. Khemani   +5 more
doaj   +1 more source

Validation of the Paediatric Nijmegen Questionnaire in Sweden: A Self‐Screening Tool for Dysfunctional Breathing

The Clinical Respiratory Journal, Volume 20, Issue 8, August 2026.
ABSTRACT Background The Nijmegen Questionnaire (NQ) is used to identify Dysfunctional Breathing (DB) in individuals with asthma. However, it has not been validated for use in children and adolescents. Objective This study aimed to validate a Swedish NQ for this population. Methods Participants aged 10–17 years with asthma were included (n = 124).
Eleni Theofanidou‐Axelsson, Malin Nygren Bonnier, Björn Nordlund, Henrik Ljungberg, Helene Alexanderson   +4 more
wiley   +1 more source

Sepsis and the muscle tissue. A narrative review

Romanian Journal of Internal Medicine, 2021
Sepsis and septic shock are considered major factors in the development of myopathy in critically ill patients, which is correlated with increased morbidity rates and ICU length of stay.
Oikonomou Eleousa, Paraskevas Themistoklis, Velissaris Dimitris   +2 more
doaj   +1 more source

A high‐fat, high‐sucrose diet exacerbates muscle and metabolic pathology and undermines glucocorticoid efficacy in dystrophin‐deficient mice

The Journal of Physiology, Volume 604, Issue 15, Page 6440-6464, 1 August 2026.
Abstract figure legend A high‐fat, high‐sucrose diet (HFHSD) exacerbated muscle and metabolic dysregulation in mdx mice while also altering the physiological response to prednisolone (Pred) In diaphragms of control diet (CD)‐fed mdx mice, prednisolone treatment improved muscle function and reduced fibrosis, inflammatory signalling, and mitochondrial ...
Morgan E. Vorwald, Swathy Krishna, Ji Heun Lee, Melissa Roths, Rudy J. Valentine, Joshua T. Selsby   +5 more
wiley   +1 more source

Evaluation of quantitative muscle MRI and an intelligent phenotyping housing system as advanced phenotyping methods in a mouse model of calpain 3‐deficient muscular dystrophy

Animal Models and Experimental Medicine, Volume 9, Issue 7, Page 1469-1479, July 2026.
We applied quantitative MRI of the lower limb and automated home‐cage phenotyping to a mouse model of calpainopathy to detect early disease changes. At 15 months, calpain 3‐deficient mice showed increased water T2 values correlating with immune cell infiltration in the soleus and gastrocnemius muscles, while assessment of motor activity revealed only ...
Nicolina Südkamp, Marlena Rohm, Gabriele Russo, Xavier Helluy, Abdulhadi Kocabas, Martijn Froeling, Felix Kleefeld, Denise Manahan‐Vaughan, Tobias Ruck, Frank Jacobsen, Matthias Vorgerd, Johannes Forsting, Lara Schlaffke   +12 more
wiley   +1 more source