Results 121 to 130 of about 66,463 (247)

Dopamine neuronal loss contributes to memory and reward dysfunction in a model of Alzheimer’s disease

Nature Communications, 2017
Dopaminergic dysfunction occurs in Alzheimer’s disease (AD). The authors show that in a mouse model of AD, loss of dopaminergic neurons in the ventral tegmental area, but not the substantia nigra, occurs at early pre-plaque stages, and may contribute to ...
Annalisa Nobili, Emanuele Claudio Latagliata, Maria Teresa Viscomi, Virve Cavallucci, Debora Cutuli, Giacomo Giacovazzo, Paraskevi Krashia, Francesca Romana Rizzo, Ramona Marino, Mauro Federici, Paola De Bartolo, Daniela Aversa, Maria Concetta Dell’Acqua, Alberto Cordella, Marco Sancandi, Flavio Keller, Laura Petrosini, Stefano Puglisi-Allegra, Nicola Biagio Mercuri, Roberto Coccurello, Nicola Berretta, Marcello D’Amelio   +21 more
doaj   +1 more source

Molecular implications of prolonged aggression experience: Th, Dat1, Snca and Bdnf gene expression in the ventral tegmental area of the victorious male mice [PDF]

, 2008
Th, Dat1, Snca and Bdnf were the genes whose mRNA levels in the ventral tegmental area of the midbrain were measured in male mice that were victorious in 20 daily agonistic interactions and in a group of such victorious mice that had later not been ...
Irina L. Kovalenko, Maxim L. Filipenko, Natalia N. Kudryavtseva, Natalia P. Bondar, Ul'   +4 more
core   +2 more sources

Pharmacologic MRI Brain Imaging Studies of Serotonin 5‐HT1 Receptor Agonists in Awake Mice

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT Serotonin (5‐hydroxytryptamine, 5‐HT) type‐1 G protein‐coupled receptors are expressed throughout the central nervous system. 5‐HT1AR activation is the putative mechanism of approved drugs for generalized anxiety disorder and major depressive disorder and is being studied in the treatment of autism and neurological disorders.
Brittany M. Brems, Erin E. Sullivan, Ryan P. McGlynn, Praveen Kulkarni, Craig F. Ferris, Raymond G. Booth   +5 more
wiley   +1 more source

NMDA and Ampa receptors in synaptic membranes of cocaine and cocaine-prazosin treated rats

Iatreia, 2005
Sensitization, an increase in behavioral responses after repeated exposure to stimulants, occurs in the mesocorticolimbic pathway that includes the ventral tegmental area (VTA), the nucleus accumbens (NAc), hippocampus and the prefrontal cortex (PFC).
W. I. Silva, N. Berríos Cartagena, M. M. Rubio Dávila, S. González Cabrera, A. Tirado Costacamps, J. G. Ortiz, C. A. Jiménez Rivera   +6 more
doaj  

Early life stress alters transcriptomic patterning across reward circuitry in male and female mice

Nature Communications, 2019
Early life stress alters behavioural response to adult stress in female mice. Here authors transcriptionally profile three brain regions involved in reward (ventral tegmental area, nucleus accumbens, and prefrontal cortex) in both male and female adult ...
Catherine Jensen Peña, Milo Smith, Aarthi Ramakrishnan, Hannah M. Cates, Rosemary C. Bagot, Hope G. Kronman, Bhakti Patel, Austin B. Chang, Immanuel Purushothaman, Joel Dudley, Hirofumi Morishita, Li Shen, Eric J. Nestler   +12 more
doaj   +1 more source

Behavioral Domain‐Specific Effects of Positive Modulation of α5 and α6 GABAA Receptors in a Rat Double‐Hit Stress Model

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
A double‐hit stress model in Sprague–Dawley rats induces alterations in motivation, motor impulsivity, and social recognition that are partially ameliorated by α5‐ and α6‐GABAA receptor modulation, suggesting domain‐specific effects of this modulation on the stress‐induced phenotype. ABSTRACT Impulsivity is an understudied area of post‐traumatic stress
Đorđe Đorović, Jovana Aranđelović, Jana Ivanović, Kristina Jezdić, Bojan Batinić, Dishary Sharmin, Prithu Mondal, James M. Cook, Miroslav M. Savić   +8 more
wiley   +1 more source

Rare but relevant: Ibogaine and cardiovascular complications—prolonged QT interval and ventricular arrhythmias

Addiction, Volume 121, Issue 6, Page 1616-1621, June 2026.
Abstract Revived interest in psychedelic‐assisted therapies has also renewed focus on ibogaine, a psychoactive alkaloid, for its notable anti‐addictive potential. Evidence from observational, open‐label, and limited randomized placebo‐controlled trials indicates that ibogaine and its metabolite noribogaine reduce craving and withdrawal symptoms in ...
Tibor Markus Brunt
wiley   +1 more source

Ventral tegmental area disruption in Alzheimer’s disease [PDF]

Aging, 2019
Bozzali, Marco, D'Amelio, Marcello, Serra, Laura   +2 more
openaire   +2 more sources

What Is the StartReact Effect?

Acta Physiologica, Volume 242, Issue 6, June 2026.
ABSTRACT The use of a startling acoustic stimulus during a simple reaction time task results in the rapid initiation of a prepared response at extremely short latencies (< 80 ms). This so‐called “StartReact effect” has been increasingly employed to probe subcortical contributions to response preparation, as it is thought to occur due to increased ...
Anthony N. Carlsen, Dana Maslovat
wiley   +1 more source

Ventral midbrain stimulation induces perceptual learning and cortical plasticity in primates

Nature Communications, 2019
Practice can improve the perception of stimuli used to achieve a task (perceptual learning). Here, the authors show in monkeys that perceptual learning can be produced even for irrelevant stimuli if the stimuli are paired with stimulation of a ...
John T. Arsenault, Wim Vanduffel
doaj   +1 more source