Results 111 to 120 of about 66,463 (247)
Nature Communications, 2018 Dopamine neurons in the ventral tegmental area (VTA) are implicated in depressive-like behaviors. Here, the authors show that cholinergic inputs to the VTA from the laterodorsal tegmentum regulate intrinsic plasticity of VTA DA neurons to mediate stress ...
Sebastian P. Fernandez +8 more
doaj +1 more source
Journal of Sleep Research, EarlyView.ABSTRACT Sleep loss and low‐grade inflammation are common stressors that affect behaviour and recovery needs. To examine their separate and combined effects on motivation for everyday behaviours, we developed a two‐hit experimental model. Participants (N = 56, 31 women) completed three experimental visits: sleep saturation (two nights, 9 h in bed/night)
John Axelsson +6 more
wiley +1 more source
KCNQ channel openers reverse depressive symptoms via an active resilience mechanism
Nature Communications, 2016 Potassium channels in the ventral tegmental area are known to regulate resilience against stress-induced depression. Here, the authors show over expression of KCNQ3 channels in VTA dopaminergic neurons or treatment with KCNQ channel openers normalizes ...
Allyson K. Friedman +14 more
doaj +1 more source
Innovations in Obesity Treatment: Beyond Adipose Tissue Dysfunction
Obesity Reviews, EarlyView.Obesity drives chronic inflammation, insulin resistance, type 2 diabetes, and cancer development through adipocyte dysfunction. Addressing this multisystemic disorder requires integrated strategies beyond diet and exercise, such as thermogenesis activation via menthol or capsinoids and appetite control through GLP‐1/GIP agonists and neuromodulation to ...
Jesica Martínez‐Godfrey +7 more
wiley +1 more source
Early adversity and the comorbidity between metabolic disease and psychopathology
The Journal of Physiology, EarlyView.Abstract figure legend Hierarchical diagram representing the interplay between the genetic background and early life adversities and its effect on multiple physiological processes that ultimately impact on the risk for the comorbdity between psychopathology and cardiometabolic disorders.
Ameyalli Gómez‐Ilescas +1 more
wiley +1 more source
Brain Research BulletinDirect and indirect evidence suggests that the prelimbic cortex (PrL) and the ventral tegmental area (VTA) are the key brain regions involved in the regulation of itch sensation and itch-related emotions.
Xing-Yu Lu +11 more
doaj +1 more source
Untangling dopamine and glutamate in the ventral tegmental area
ABSTRACT Ventral tegmental area (VTA) dopamine neurons are of great interest for their central roles in motivation, learning, and psychiatric disorders. While hypotheses of VTA dopamine neuron function posit a homogenous role in behavior (e.g., prediction error), they do not account for molecular heterogeneity.
Emily D. Prévost +12 more
openaire +2 more sources
Double Asymmetric Spin Echo EPI (dASE‐EPI) Enables fMRI of the Entire Rat Brain at 9.4 T
Magnetic Resonance in Medicine, Volume 96, Issue 1, Page 366-373, July 2026.ABSTRACT Purpose Development and evaluation of a double asymmetric spin echo planar imaging (dASE‐EPI) sequence to balance sensitivity to blood oxygenation level‐dependent (BOLD) contrast with mitigation of susceptibility‐induced intravoxel spin dephasing in ultra high‐field rodent brain imaging.
Kyle A. Johnson +2 more
wiley +1 more source
Akathisia Induced by Metoclopramide in a Pregnant Woman With Nausea and Vomiting: A Case Report
Neuropsychopharmacology Reports, Volume 46, Issue 2, June 2026.This case report describes a patient who was hospitalized at 33 weeks of gestation and diagnosed with metoclopramide‐induced akathisia. Although the akathisia symptoms resolved 3 days after discontinuation of metoclopramide, a possible interaction with dextromethorphan, which the patient had been orally administering prior to hospitalization, cannot be
Ryohei Nakamura +6 more
wiley +1 more source
Adolescent Exposure to Nicotine and Ethanol Attenuates Adult Nicotine Reward Sensitivity in Rats
Neuropsychopharmacology Reports, Volume 46, Issue 2, June 2026.We investigated how chronic exposure to nicotine, ethanol, or their combination during adolescence influences adult conditioned place preference (CPP) for nicotine. No significant CPP was observed in any of the drug‐exposed groups, suggesting adolescent exposure to addictive substances does not uniformly increase vulnerability to nicotine reward ...
Michimasa Toyoshima +5 more
wiley +1 more source