Results 101 to 110 of about 66,463 (247)

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source

Corticolimbic catecholamines in stress: A computational model of the appraisal of controllability [PDF]

, 2014
Appraisal of a stressful situation and the possibility to control or avoid it is thought to involve frontal-cortical mechanisms. The precise mechanism underlying this appraisal and its translation into effective stress coping (the regulation of ...
Alessandro, Valzania, Cabib, Simona, Emanuele Claudio, Latagliata, Francesco, Mannella, Gianluca, Baldassarre, Marco, Mirolli, PUGLISI ALLEGRA, Stefano, Raymond J., Dolan, Vincenzo G., Fiore   +8 more
core   +2 more sources

Amylin analogues as a novel perspective in anti‐obesity therapy

British Journal of Pharmacology, EarlyView.
Abstract Public health systems face a major challenge because of the worldwide obesity epidemic. The number of obese individuals has increased dramatically and, even in Switzerland which may be considered a relatively “lean” country, the numbers are alarmingly high and have reached almost 50% of the adult population.
Thomas A. Lutz
wiley   +1 more source

Antagonism of GABA-B but not GABA-A receptors in the VTA prevents stress- and intra-VTA CRF-induced reinstatement of extinguished cocaine seeking in rats [PDF]

, 2016
Stress-induced reinstatement of cocaine seeking requires corticotropin releasing factor (CRF) actions in the ventral tegmental area (VTA). However the mechanisms through which CRF regulates VTA function to promote cocaine use are not fully understood ...
Baker, David A., Blacktop, Jordan M., Hoof, Matthew Van, Mantsch, John R., Mayer, Matthieu, Vranjkovic, Oliver   +5 more
core   +2 more sources

Postprandial Glucagon Action in the Human Brain

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Elevated fasting glucagon is linked to hyperglycemia, but postprandial glucagon effects are less understood. Recent evidence suggests metabolic benefits of rising glucagon after oral glucose intake, potentially impacting brain‐mediated whole‐body metabolism.
Robert Wagner, Stephanie Kullmann, Julia Hummel, Katsiaryna Prystupa, Elena Hosenfeld, Ralf Veit, Andreas L. Birkenfeld, Hans‐Ulrich Häring, Hubert Preissl, Andreas Fritsche, Andreas Peter, Martin Heni   +11 more
wiley   +1 more source

Active inference, evidence accumulation, and the urn task [PDF]

, 2015
Deciding how much evidence to accumulate before making a decision is a problem we and other animals often face, but one that is not completely understood.
Attias H., Beal M. J., Karl Friston, Michael Moutoussis, Philipp Schwartenbeck, Raymond J. Dolan, Schwartenbeck P., Thomas H. B. FitzGerald   +7 more
core   +1 more source

Neural correlates of pure apathy in multiple sclerosis: An exploratory neuroimaging study

Journal of Neuropsychology, EarlyView.
Abstract Pure apathy is relatively common in people with Multiple Sclerosis (PwMS), but its neural mechanisms remain unexplored. Therefore, we investigated the neural correlates of pure apathy in PwMS, differentiating it from depression. Sixty‐two PwMS underwent neuropsychological assessments and Magnetic Resonance Imaging scans.
Valentina Torchia, Vera Gramigna, Mariachiara Gaita, Daniele Spitaleri, Antonio Costanzo, Liana Palermo, Florindo d'Onofrio, Simona Raimo   +7 more
wiley   +1 more source

Granulocyte-Colony-Stimulating Factor Alters the Proteomic Landscape of the Ventral Tegmental Area

Proteomes, 2018
Cocaine addiction is characterized by aberrant plasticity of the mesolimbic dopamine circuit, leading to dysregulation of motivation to seek and take drug.
Nicholas L. Mervosh, Rashaun Wilson, Navin Rauniyar, Rebecca S. Hofford, Munir Gunes Kutlu, Erin S. Calipari, TuKiet T. Lam, Drew D. Kiraly   +7 more
doaj   +1 more source

Parasomnias and sleep‐related movement disorders induced by drugs in the adult population: a review about iatrogenic medication effects

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Parasomnias and sleep‐related movement disorders (SRMD) are major causes of sleep disorders and may be drug induced. The objective of this study was to conduct a systematic review of the literature to examine the association between drug use and the occurrence of parasomnias and SRMD.
Sylvain Dumont, Vanessa Bloch, Agnès Lillo‐Lelouet, Christine Le Beller, Pierre A. Geoffroy, Marc Veyrier   +5 more
wiley   +1 more source

SARS-CoV-2 propagation to the TPH2-positive neurons in the ventral tegmental area induces cell death via GSK3β-dependent accumulation of phosphorylated tau.

PLoS ONE
COVID-19, an infectious disease caused by SARS-CoV-2, was declared a pandemic by the WHO in 2020. Psychiatric symptoms including sleep disturbance, memory impairment, and depression are associated with SARS-CoV-2 infection. These symptoms are causes long-
Motoki Imai, Fumitaka Kawakami, Takayuki Uematsu, Toshihide Matsumoto, Rei Kawashima, Yoshifumi Kurosaki, Shun Tamaki, Shotaro Maehana, Takafumi Ichikawa, Hideaki Hanaki, Hidero Kitazato, Makoto Kubo   +11 more
doaj   +1 more source