Results 81 to 90 of about 66,463 (247)

From traumatic childhood to cocaine abuse: the critical function of the immune system [PDF]

, 2018
Background: Experiencing traumatic childhood is a risk factor for developing substance use disorder (SUD), but the mechanisms that underlie this relationship have not been determined.
Aricò, Eleonora, Bussone, Silvia, Carola, Valeria, Casella, Pietro, Catale, Clarissa, Chiurchiù, Valerio, Di Sabato, Paola, D’Argenio, Alberto, Guatteo, Ezia, Lo Iacono, Luisa, Maccarrone, Mauro, Martini, Alessandro, Mercuri, Nicola B., Perrone, Fabiana, Puglisi-Allegra, Stefano, Troisi, Alfonso, Valzania, Alessandro, Viscomi, Maria Teresa   +17 more
core   +1 more source

LTP of GABAergic synapses in the ventral tegmental area and beyond [PDF]

The Journal of Physiology, 2008
One of the mechanisms by which the experience‐dependent reorganization of neural circuitry can occur is through changes in synaptic strength. Almost every excitatory synapse in the mammalian brain exhibits LTP (long‐term potentiation) or LTD (long‐term depression), two cellular mechanisms of synaptic plasticity.
Fereshteh S, Nugent, Julie A, Kauer
openaire   +2 more sources

Fiber‐type soft bioelectronics for wearable and implantable sensing and therapy

BMEMat, EarlyView.
Fiber‐type soft bioelectronics are emerging as versatile platforms for wearable and implantable health monitoring and therapeutic applications. These bioelectronics use organic and inorganic matrices combined with advanced fillers, which feature high conductivity, electrochemical sensitivity, softness, and biocompatibility.
Haneul Kim, Hak Yong Kim, Ja Hoon Koo, Gi Doo Cha, Dae‐Hyeong Kim, Hye Jin Kim   +5 more
wiley   +1 more source

The Role of Medial Prefrontal Cortex and Ventral Tegmental Areas in Withdrawal Syndrome in Morphine Addicted Male Rats

مجله دانشکده پزشکی اصفهان, 2020
Background: One of the problems of addiction treatment is the relapsing of withdrawal syndrome signs in the addicted person. Rewarding brain regions such as medial prefrontal cortex (mPFC) and ventral tegmental area (VTA) are involved in addiction and ...
Asal Keramatian, Hojjatallah Alaei, Akram Eidi, Maryam Radahmadi   +3 more
doaj   +1 more source

Augmentation of ventral tegmental area stimulation-induced feeding by both stimulation and lesion of the contralateral ventral tegmental area in the rat

Acta Neurobiologiae Experimentalis, 1999
Unilateral lesions of the ventral tegmental area (VTA) facilitate behavioral responses (feeding and exploration) induced by electrical stimulation of the VTA in the contralateral hemisphere. It was hypothesized that this facilitation may result from a lesion-induced compensatory increase in dopamine transmission in the intact hemisphere. In the present
M, Maliszewska-Scisło, W, Trojniar
openaire   +2 more sources

Leptin Reduces Running in a Rodent Anorexia Nervosa Model via a Distributed Neural Network

European Eating Disorders Review, EarlyView.
ABSTRACT Objective Hyperactivity is a persistent and clinically relevant symptom in anorexia nervosa (AN). Hyperactivity is inversely correlated with leptin levels. While systemic leptin administration attenuates hyperactivity in rodent models, the specific brain regions mediating this effect remain unclear.
Nick J. M. Papavoine, Melissa N. Veendijk, Jessie Nijman, Mieneke C. M. Luijendijk, Inge G. Wolterink‐Donselaar, Frank J. Meye, Roger A. H. Adan   +6 more
wiley   +1 more source

Reward circuitry is perturbed in the absence of the serotonin transporter [PDF]

, 2009
The serotonin transporter (SERT) modulates the entire serotonergic system in the brain and influences both the dopaminergic and norepinephrinergic systems.
Bearer, Elaine L., Boulat, Benoit, Jacobs, Russell E., Janvelyan, Davit, Zhang, Xiaowei   +4 more
core   +1 more source

Quantitative Analysis of Locus Coeruleus Neurons and Thalamic Noradrenergic Axons in a Progressive 1‐Methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine Monkey Model of Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Parkinson's disease is mainly characterized by dopaminergic neurodegeneration in the substantia nigra pars compacta (SNc) and α‐synuclein accumulation. The locus coeruleus (LC) is also affected in Parkinson's disease and linked to some nonmotor symptoms, but the extent and timing of its degeneration remain unclear.
Megan Carrillo, Nagore Hernández‐Pinedo, Josefa Zaldivar‐Diez, Isabel Pérez‐Santos, José A. Obeso, Carmen Cavada, Javier Blesa   +6 more
wiley   +1 more source

Degradation of Perineuronal Nets in the Ventral Hippocampus of Adult Rats Recreates an Adolescent-Like Phenotype of Stress Susceptibility

Biological Psychiatry Global Open Science
Background: Psychiatric disorders often emerge during late adolescence/early adulthood, a period with increased susceptibility to socioenvironmental factors that coincides with incomplete parvalbumin interneuron (PVI) development.
Débora A.E. Colodete, Anthony A. Grace, Francisco S. Guimarães, Felipe V. Gomes   +3 more
doaj   +1 more source

Failure of Intravenous Morphine to Serve as an Effective Instrumental Reinforcer in Dopamine D2 Receptor Knock-Out Mice [PDF]

, 2002
The rewarding effects of opiates are thought to be mediated through dopaminergic mechanisms in the ventral tegmental area, dopamine-independent mechanisms in the nucleus accumbens, or both. The purpose of the present study was to explore the contribution
Elmer, Greg I., Grandy, David K., Low, Malcolm J., Pieper, Jeanne O., Rubinstein, Marcelo, Wise, Roy A.   +5 more
core   +1 more source