Results 71 to 80 of about 6,470,327 (195)

KCNQ channel openers reverse depressive symptoms via an active resilience mechanism

Nature Communications, 2016
Potassium channels in the ventral tegmental area are known to regulate resilience against stress-induced depression. Here, the authors show over expression of KCNQ3 channels in VTA dopaminergic neurons or treatment with KCNQ channel openers normalizes ...
Allyson K. Friedman, Barbara Juarez, Stacy M. Ku, Hongxing Zhang, Rhodora C. Calizo, Jessica J. Walsh, Dipesh Chaudhury, Song Zhang, Angel Hawkins, David M. Dietz, James W. Murrough, Maria Ribadeneira, Erik H. Wong, Rachael L. Neve, Ming-Hu Han   +14 more
doaj   +1 more source

The expression of Cre recombinase recapitulates that of Th in dopaminergic neurons in the ventral tegmental area and substantia nigra.

, 2016
A combination of anti-TH immunostaining and Cre fluorescence in situ hybridization (A-A”, D-E”) as well as double fluorescence in situ hybridization with both Th and Cre riboprobes (B-C”) were employed to examine the co-localization of Cre mRNA and the ...
Andrew Brown (126751), Dan Fisher (1887925), Joe Warren (274996), Yumei Wu (67781), Xiaoxia Cui (532500), Zhenyi Liu (82686)   +5 more
core   +1 more source

The projection from the prelimbic cortex to the ventral tegmental area negatively regulates 5-HT-induced itch-scratching and positively regulates itch-related aversion in rats

Brain Research Bulletin
Direct and indirect evidence suggests that the prelimbic cortex (PrL) and the ventral tegmental area (VTA) are the key brain regions involved in the regulation of itch sensation and itch-related emotions.
Xing-Yu Lu, Jun-Fei Teng, Juan Yao, Xuan Li, Bing Wu, Xue-Qiang Hu, Ping Wang, Xiao-Qian Jiang, Jian-Feng Sui, Ke-Hui Hu, Yue-Ming Xu, Shu-Lei Liu   +11 more
doaj   +1 more source

Nicotine withdrawal in the rat: role of alpha7 nicotinic receptors in the ventral tegmental area

, 1999
Previous data show that nicotinic receptors in the ventral tegmental area are of importance for the nicotine withdrawal syndrome. Here we have investigated the specific role of alpha7 nicotinic receptors in the ventral tegmental area for the ...
Nomikos, GG, Svensson, TH, Panagis, G, Hildebrand, BE   +3 more
core   +1 more source

Ventral tegmental area disruption in Alzheimer’s disease [PDF]

Aging, 2019
Bozzali, Marco, D'Amelio, Marcello, Serra, Laura   +2 more
openaire   +2 more sources

Determination of neurotensin projections to the ventral tegmental area in mice

Neuropeptides, 2018
Pharmacologic treatment with the neuropeptide neurotensin (Nts) modifies motivated behaviors such as feeding, locomotor activity, and reproduction. Dopamine (DA) neurons of the ventral tegmental area (VTA) control these behaviors, and Nts directly modulates the activity of DA neurons via Nts receptor-1.
Woodworth, Hillary L., Brown, Juliette A., Batchelor, Hannah M., Bugescu, Raluca, Leinninger, Gina M.   +4 more
openaire   +2 more sources

Distinct microcircuits in the dorsal raphe to ventral tegmental area projection pathway [PDF]

, 2019
Dopamine and gamma-aminobutyric acid (GABA) neurons in the ventral tegmental area have been shown to be critically involved in motivational behavior. How these neurons encode the relevant features of motivational behavior to generate behavioral output is
Chang, Anna
core  

The dual orexin/hypocretin receptor antagonist, almorexant, in the ventral tegmental area attenuates ethanol self-administration. [PDF]

, 2012
Recent studies have implicated the hypocretin/orexinergic system in reward-seeking behavior. Almorexant, a dual orexin/hypocretin R(1) and R(2) receptor antagonist, has proven effective in preclinical studies in promoting sleep in animal models and was ...
Steven P Lieske, Srinivasan, Subhashini, Jeffrey A Simms, Henry Yi, Jade J. Bito-Onon, Bito-Onon Jade J., Nielsen, Carsten, Frederic Woodward Hopf, Jeffrey A. Simms, Steven P. Lieske, Selena E. Bartlett, Hopf Frederic Woodward, Bonci, Antonello, Bito-Ono, Jade, Bartlett, Selena, Simms, Jeff, Carsten K Nielsen, Nielsen Carsten K., Bartlett Selena E., Hopf, Woody, Bonci Antonello, Simms Jeffrey A., Carsten K. Nielsen, Yi, Henry, Subhashini Srinivasan, Yi Henry, Selena E Bartlett, Srinivasan Subhashini, Lieske Steven P., Jade J Bito-Onon, Lieske, Steven, Antonello Bonci   +31 more
core   +2 more sources

NMDA and Ampa receptors in synaptic membranes of cocaine and cocaine-prazosin treated rats

Iatreia, 2005
Sensitization, an increase in behavioral responses after repeated exposure to stimulants, occurs in the mesocorticolimbic pathway that includes the ventral tegmental area (VTA), the nucleus accumbens (NAc), hippocampus and the prefrontal cortex (PFC).
W. I. Silva, N. Berríos Cartagena, M. M. Rubio Dávila, S. González Cabrera, A. Tirado Costacamps, J. G. Ortiz, C. A. Jiménez Rivera   +6 more
doaj  

Dopamine neuronal loss contributes to memory and reward dysfunction in a model of Alzheimer’s disease

Nature Communications, 2017
Dopaminergic dysfunction occurs in Alzheimer’s disease (AD). The authors show that in a mouse model of AD, loss of dopaminergic neurons in the ventral tegmental area, but not the substantia nigra, occurs at early pre-plaque stages, and may contribute to ...
Annalisa Nobili, Emanuele Claudio Latagliata, Maria Teresa Viscomi, Virve Cavallucci, Debora Cutuli, Giacomo Giacovazzo, Paraskevi Krashia, Francesca Romana Rizzo, Ramona Marino, Mauro Federici, Paola De Bartolo, Daniela Aversa, Maria Concetta Dell’Acqua, Alberto Cordella, Marco Sancandi, Flavio Keller, Laura Petrosini, Stefano Puglisi-Allegra, Nicola Biagio Mercuri, Roberto Coccurello, Nicola Berretta, Marcello D’Amelio   +21 more
doaj   +1 more source