Results 51 to 60 of about 66,463 (247)

TPH2 in the ventral tegmental area of the male rat brain [PDF]

Brain Research Bulletin, 2011
This study surveyed the distribution of tryptophan hydroxylase 2 (TPH2) mRNA, protein, and enzymatic activity throughout the male Sprague-Dawley rat brain. TPH2 is the genetic isoform of TPH that catalyzes the rate-limiting step in serotonin biosynthesis within the central nervous system.
Nurgul, Carkaci-Salli, Ugur, Salli, Kara L, Kuntz-Melcavage, Michael M, Pennock, Hande, Ozgen, Izel, Tekin, Willard M, Freeman, Kent E, Vrana   +7 more
openaire   +2 more sources

CTBPro: A Next‐Generation Cholera Toxin Subunit B‐Based Neuroanatomical Tracer With Superior Brightness, Stability, and Sensitivity for Enhanced Neural Circuit Mapping

Advanced Science, EarlyView.
CTBPro is a next‐generation cholera toxin B–based tracer engineered by fusing CTB to the ultra‐stable fluorescent protein mBaojin. Exhibiting markedly enhanced molar brightness, CTBPro enables high‐fidelity neuronal labeling across multiple administration routes.
Xinghua Quan, Yude Lou, Huiqi Xie, Yifei Wang, Yanzhe Zhang, Yiran Ge, Linhe Yang, Xiaoxuan Zhang, Qingmiao Zhou, Huaizong Shen, Longxing Cao, Xin Jin, Jie‐Min Jia   +12 more
wiley   +1 more source

Interactions between the neuromodulatory systems and the amygdala: exploratory survey using the Allen Mouse Brain Atlas. [PDF]

, 2013
Neuromodulatory systems originate in nuclei localized in the subcortical region of the brain and control fundamental behaviors by interacting with many areas of the central nervous system.
Krichmar, Jeffrey L, Zaldivar, Andrew
core   +1 more source

mGluR5 in ECCCK to BLA Circuit Modulates Depressive‐Like Phenotypes through CCK Signaling

Advanced Science, EarlyView.
Dysregulation of mGluR5 and CCK signaling contributes to major depressive disorder, yet circuit‐level mechanisms remain unclear. Here, the ECCCK→BLA pathway is identified as a critical regulator of affective behavior. mGluR5 modulates synaptic function and CCK signaling within this circuit, controlling stress susceptibility and depressive‐like states ...
Muhammad Asim, Huajie Wang, Gao Qianqian, Abdul Waris, Jufang He   +4 more
wiley   +1 more source

Circadian regulation of hedonic appetite in mice by clocks in dopaminergic neurons of the VTA

Nature Communications, 2020
In addition to promoting overconsumption, palatable diets dampen daily intake patterns, which further augments metabolic dysfunction. Here, the authors find that in mice, circadian clocks in dopaminergic neurons in the ventral tegmental area drive ...
C. E. Koch, K. Begemann, J. T. Kiehn, L. Griewahn, J. Mauer, M. E. Hess, A. Moser, S. M. Schmid, J. C. Brüning, H. Oster   +9 more
doaj   +1 more source

Reduced GABA-B/GIRK-mediated regulation of the VTA following a single exposure to cocaine [PDF]

, 2012
In this paper, Arora and colleagues expand on their previous work on GIRK channels in the ventral tegmental area (VTA) presenting evidence that a single exposure to cocaine reduces inhibitory GABAergic transmission to dopamine (DA) neurons in the ventral
Andrew Varnell, Brian Cadle, Donald C. Cooper   +2 more
core   +2 more sources

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Determination of circuit-specific morphological adaptations in ventral tegmental area dopamine neurons by chronic morphine

Molecular Brain, 2019
Chronic opiate exposure induces neuroadaptations in the mesocorticolimbic system including ventral tegmental area (VTA) dopamine (DA) neurons, whose soma size is decreased following opiate exposure.
Sarah C. Simmons, Katie Wheeler, Michelle S. Mazei-Robison   +2 more
doaj   +1 more source

Acute High Fat Diet Consumption Activates the Mesolimbic Circuit and Requires Orexin Signaling in a Mouse Model [PDF]

, 2014
Overconsumption of palatable energy-dense foods has negative health implications and it is associated with obesity andseveral eating disorders. Currently, little is known about the neuronal circuitries activated by the acute ingestion of arewarding ...
Patrone, Anabela, Perello, Mario, Reynaldo, Mirta Beatriz, Valdivia Torres, Lesly Spring   +3 more
core   +2 more sources

Glutamatergic and dopaminergic neurons in the mouse ventral tegmental area [PDF]

European Journal of Neuroscience, 2015
AbstractThe ventral tegmental area (VTA) comprises dopamine (DA), γ‐aminobutyric acid (GABA) and glutamate (Glu) neurons. Some rat VTA Glu neurons, expressing vesicular glutamate transporter 2 (VGluT2), co‐express tyrosine hydroxylase (TH). While transgenic mice are now being used in attempts to determine the role of VGluT2/TH neurons in reward and ...
Tsuyoshi, Yamaguchi, Jia, Qi, Hui-Ling, Wang, Shiliang, Zhang, Marisela, Morales   +4 more
openaire   +2 more sources