Results 91 to 100 of about 101,449 (340)
Neoplasia: An International Journal for Oncology Research, 2010 The proteasome inhibitor bortezomib is clinically approved for the treatment of multiple myeloma. However, long-term remissions are difficult to achieve, and myeloma cells often develop secondary resistance to proteasome inhibitors.
Silke Meister +6 more
doaj +1 more source
Modulation of calcium and potassium currents by lamotrigine [PDF]
, 1998 Actions of the new antiepileptic drug lamotrigine (LTG) were characterized using extracellular and whole cell patch clamp recordings from rat CAI and CA3 pyramidal cells in vitro.
Greene, Robert W. +3 more
core +1 more source
Journal of Infectious Diseases, 2014 Drug tolerance likely represents an important barrier to tuberculosis treatment shortening. We previously implicated the Mycobacterium tuberculosis efflux pump Rv1258c as mediating macrophage-induced tolerance to rifampicin and intracellular growth.
Kristin N. Adams +2 more
semanticscholar +1 more source
ChemMedChem, EarlyView.Analysis of publicly available data on the biological activities associated with the Staphylococcus aureus NorA efflux pump shows critical inconsistencies and homogeneity issues that hinder the discovery of NorA inhibitors. Based on the tips extracted from this analysis, a standardized experimental pipeline is proposed to improve data quality and ...
Andrea Astolfi +6 more
wiley +1 more source
International Journal of Hepatology, 2020 Paracetamol, chemically known as acetaminophen, if taken in higher doses has hepatotoxic potential. Cimetidine by inhibiting the cytochromal enzymes and reducing the production of the toxic metabolite can reduce the hepatotoxic potential while Verapamil ...
Lubna Danish +5 more
doaj +1 more source
Design and Synthesis of Tetrahydropyrrolo[3,4‐c]Pyrazole Sigma‐1 Receptor Ligands
ChemMedChem, EarlyView.This study highlights the tetrahydropyrrolo[3,4‐c]pyrazole scaffold as a promising platform for S1R ligands development. Key findings include compound 19’s high S1R affinity (Ki=75 nM), influenced by strategic nitrogen substitutions and reduced steric hindrance.
Giuseppe Cosentino +7 more
wiley +1 more source
Verapamil and Alzheimer’s Disease: Past, Present, and Future
Frontiers in Pharmacology, 2020 Verapamil is a phenylalkylamine class calcium channel blocker that for half a century has been used for the treatment of cardiovascular diseases. Nowadays, verapamil is also considered as a drug option for the treatment of several neurological and ...
Natalija Popović +12 more
doaj +1 more source
Verapamil chronicles: advances from cardiovascular to pancreatic β-cell protection
Frontiers in Pharmacology, 2023 Verapamil is a well-known drug used for treating angina and hypertension. Emerging data from current clinical trials suggest that this calcium channel blocker has a potential benefit for pancreatic β-cells through the elevation and sustenance of C ...
Hossein Arefanian +7 more
doaj +1 more source
Role of protein kinase C in inhibition of renin release caused by vasoconstrictors [PDF]
, 1986 It was the aim of the present study to get insight into some of the intracellular mechanisms by which the vasoconstrictor hormones angiotensin II (ANG II), arginine vasopressin (AVP), and norepinephrine (NE) inhibit renin release from renal ...
Bauer, C. +7 more
core +1 more source
Antimicrobial Agents and Chemotherapy, 2014 Bedaquiline is a newly approved drug for the treatment of multidrug-resistant tuberculosis, but there are concerns about its safety in humans. We found that the coadministration of verapamil with subinhibitory doses of bedaquiline gave the same ...
Shashank Gupta, S. Tyagi, W. Bishai
semanticscholar +1 more source