Results 91 to 100 of about 76,436 (232)

Independent derivations of the axis of arrhythmia for predicting drug‐induced torsades de pointes

British Journal of Pharmacology, Volume 182, Issue 18, Page 4299-4313, September 2025.
Abstract Background and Purpose: Torsades de pointes is a potentially lethal ventricular arrhythmia that can be induced by many classes of drugs. The risk for a given drug depends upon the combination of cardiac ion channels that it targets. The axis of arrhythmia quantifies that risk. It is a conceptual line in the electrophysiology that describes the
Stewart Heitmann, Jamie I. Vandenberg, Adam P. Hill   +2 more
wiley   +1 more source

Recipient Versus Donor CYP3A4/5 Genotypes in Adult Liver Transplant Recipients to Achieve Therapeutic Tacrolimus Concentrations Early Post‐Transplant

Clinical and Translational Science, Volume 18, Issue 9, September 2025.
ABSTRACT Tacrolimus is an immunosuppressive agent with difficult dosing due to a narrow therapeutic index and large interpatient pharmacokinetic variability, for which CYP3A5 variation plays a role. Tacrolimus/CYP3A5 pharmacogenetic guidelines exclude liver transplant patients with a donor/recipient CYP3A5 mismatch. We sought to determine the influence
Eda Eken, Sergio Duarte, Isabella Angeli‐Pahim, Alexandra D. Ladd, Curtis Warren, Taimour Y. Langaee, Ali Zarrinpar, Julie A. Johnson   +7 more
wiley   +1 more source

Preservation of high-energy phosphates by verapamil in reperfused myocardium. [PDF]

, 1984
Rüdiger Lange, Joanne S. Ingwall, S L Hale, Kevin J. Alker, Eugene Braunwald, Robert A. Kloner   +5 more
openalex   +1 more source

Activation of Extracellular-signal Regulated Kinase (ERK1/2) by Fluid Shear is Ca\u3csup\u3e2+\u3c/sup\u3e- and ATP-dependent in MC3T3-E1 Osteoblasts [PDF]

, 2008
To determine the role of Ca2+ signaling in activation of the Mitogen-Activated Protein Kinase (MAPK) pathway, we subjected MC3T3-E1 pre-osteoblastic cells to inhibitors of Ca2+ signaling during application of fluid shear stress (FSS).
Duncan, Randall L., Geist, Derik J., Genetos, Damian C., Ke, Hua Zhe, Li, Jiliang, Liu, Dawei, Shao, Ying, Turner, Charles H.   +7 more
core   +1 more source

Effect of Verapamil on the Normal Action Potential and on a Calcium Dependent Slow Response of Canine Cardiac Purkinje Fibers

, 1974
Paul F. Cranefield, Ronald Aronson, Andrew L. Wit   +2 more
openalex   +1 more source

Verapamil pharmacokinetics and apparent hepatic and renal blood flow. [PDF]

, 1985
PA Meredith, HL Elliott, Fabrizio Pasanisi, A. W. Kelman, DJ Sumner, JL Reid   +5 more
openalex   +1 more source

Effect of verapamil on cholesteryl ester hydrolysis and reesterification in macrophages. [PDF]

, 1987
Oliver Stein, Y. Stein
openalex   +1 more source

Intracellular control of renin release - an overview [PDF]

, 1986
Kurtz, Armin
core   +1 more source

Effects of simulated weightlessness on regional blood flow specifically during cardiovascular stress [PDF]

Significant changes in the cardiovasular system of humans and animals have been observed following exposure to prolonged periods of weightlessness during space flight.
Harrison, D. C.
core   +1 more source

Idiopathic Fascicular Ventricular Tachycardia [PDF]

, 2004
Idiopathic fascicular ventricular tachycardia is an important cardiac arrhythmia with specific electrocardiographic features and therapeutic options. It is characterized by relatively narrow QRS complex and right bundle branch block pattern. The QRS axis
Francis, Johnson, Gupta, Anoop K, K, Venugopal, N, Sudhayakumar, SA, Khadar   +4 more
core   +2 more sources