Results 101 to 110 of about 101,449 (340)
Clinical Pharmacology &Therapeutics, EarlyView.Conducting clinical studies on drug–drug‐gene interactions (DDGIs) and extrapolating the findings into clinical dose recommendations is challenging due to the high complexity of these interactions. Here, physiologically‐based pharmacokinetic (PBPK) modeling networks present a new avenue for exploring such complex scenarios, potentially informing ...
Simeon Rüdesheim +14 more
wiley +1 more source
Verapamil decreases the glucose-lowering effect of metformin in healthy volunteers.
British Journal of Clinical Pharmacology, 2014 AIM The organic cation transporter 1 (OCT1) plays a key role in the cellular transport of metformin and its subsequent glucose-lowering effect. A recent non-clinical study reported that metformin uptake into hepatocytes is regulated via OCT1, and that ...
S. Cho, C. Kim, Eun Sug Park, J. Chung
semanticscholar +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.A common issue in clinical drug development involves drug–drug interactions (DDI) that may lead to altered drug exposure and subsequent altered safety and efficacy of an investigational drug or concomitant medications (conmeds) in the target patient population.
Alice S. Tang +6 more
wiley +1 more source
Verapamil Inhibits Aspergillus Biofilm, but Antagonizes Voriconazole
Journal of Fungi, 2017 The paucity of effective antifungals against Aspergillus and increasing resistance, the recognition of the importance of Aspergillus biofilm in several clinical settings, and reports of verapamil—a calcium channel blocker—efficacy against Candida biofilm
Hasan Nazik +2 more
doaj +1 more source
Evaluation of person-level heterogeneity of treatment effects in published multiperson N-of-1 studies: systematic review and reanalysis. [PDF]
, 2018 OBJECTIVE:Individual patients with the same condition may respond differently to similar treatments. Our aim is to summarise the reporting of person-level heterogeneity of treatment effects (HTE) in multiperson N-of-1 studies and to examine the evidence ...
Balk, Ethan M +8 more
core +1 more source
FEMS Yeast Research, 2014 Candida albicans morphogenesis and gastrointestinal colonization are closely associated with the pathogenicity of this pathogen. This study investigated the in vitro and in vivo effect of verapamil, a calcium channel blocker, on these processes. Exposure
Qilin Yu +8 more
semanticscholar +1 more source
Drug Testing and Analysis, EarlyView.Simultaneous qualitative and quantitative analysis of 62 drugs and seven active metabolites in human blood plasma by automated liquid chromatography linear ion trap mass spectrometry. ABSTRACT Rapid and comprehensive qualitative and quantitative analytical procedures are crucial in 24/7 emergency toxicology (ET) to support diagnosis and treatment of ...
Selina Hemmer +4 more
wiley +1 more source
Prolongation of AV nodal refractoriness by Ruta graveolens in isolated rat hearts [PDF]
, 2008 Objectives: To evaluate concentration-dependent effects of total extract of Rusta graveolens and its purified alkaloid fraction on the nodal basic and functional properties.
Golalipour, M.J. +4 more
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The first-line cluster headache medication verapamil alters the circadian period and elicits sex-specific sleep changes in mice [PDF]
, 2022 Verapamil is the first-line preventive medication for cluster headache, an excruciating disorder with strong circadian features. Whereas second- and third-line preventives include known circadian modulators, such as melatonin, corticosteroids, and ...
Burish, Mark J. +8 more
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