Results 51 to 60 of about 76,436 (232)
CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 523-539, March 2025.Abstract Ritonavir (RTV) is a potent CYP3A inhibitor that is widely used as a pharmacokinetic (PK) enhancer to increase exposure to select protease inhibitors. However, as a strong and complex perpetrator of CYP3A interactions, RTV can also enhance the exposure of other co‐administered CYP3A substrates, potentially causing toxicity.
Lien Thi Ngo +5 more
wiley +1 more source
Frequency Analysis of Atrial Fibrillation From the Surface Electrocardiogram [PDF]
, 2004 Atrial fibrillation (AF) is the most common arrhythmia encountered in clinical practice. Neither the natural history of AF nor its response to therapy are sufficiently predictable by clinical and echocardiographic parameters.
Bollmann, Andreas +4 more
core
Plasmodium falciparum ligand binding to erythrocytes induce alterations in deformability essential for invasion [PDF]
, 2017 The most lethal form of malaria in humans is caused by Plasmodium falciparum. These parasites invade erythrocytes, a complex process involving multiple ligand-receptor interactions.
Cowman, Alan +12 more
core +2 more sources
World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.ABSTRACT Spasmodic dysphonia is a laryngeal dystonia that can present as adductor, abductor, or mixed types, with or without tremor. The etiology is not understood fully. Comprehensive evaluation is required to establish the diagnosis. Treatments include voice therapy, medications, botulinum toxin injection, laryngeal surgery, deep brain stimulation ...
Aaron J. Jaworek, Robert T. Sataloff
wiley +1 more source
Andrology, EarlyView.Abstract Background Real‐world data on Peyronie's disease remains limited. Objectives Describe the demographics, clinical characteristics, and therapeutic management of Peyronie's disease patients in the United States. Materials and methods A retrospective analysis was conducted using the PearlDiver Mariner database (2010–2022).
Angelo Orsini +15 more
wiley +1 more source
Reasoning by analogy in the generation of domain acceptable ontology refinements [PDF]
, 2010 Refinements generated for a knowledge base often involve the learning of new knowledge to be added to or replace existing parts of a knowledge base. However, the justifiability of the refinement in the context of the domain (domain acceptability) is ...
L. Moss +5 more
core +1 more source
Acta Paediatrica, EarlyView.ABSTRACT Aim The aim of this review is to systematically summarise the evidence on the effectiveness of riboflavin (vitamin B2) or supplements containing riboflavin in preventing paediatric migraines. Methods This systematic review followed the Joanna Briggs Institute methodology and is reported to adhere to the Preferred Reporting Items for Systematic
Elisa Martello +13 more
wiley +1 more source
Structure‐based discovery of thiamine uptake inhibitors
British Journal of Pharmacology, EarlyView.Background and Purpose Thiamine (vitamin B1) is an essential coenzyme and catalyses various reactions in central metabolic pathways. Since mammals have lost the ability to synthesise thiamine de novo, this micronutrient has to be imported via the high affinity solute carriers SLC19A2 and A3 across the plasma membrane.
Florian Gabriel +2 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.Background and Purpose Dysregulation of the IL‐6/glycoprotein 130(gp130)/STAT3 signalling axis is implicated in several human diseases, particularly cancer. Notably, gp130, a single transducer of this signalling axis, is a target for ovarian cancer treatment. However, data regarding small‐molecule inhibitors of gp130 are lacking. Therefore, we aimed to
Sun‐Ae Park +11 more
wiley +1 more source