Results 61 to 70 of about 76,436 (232)

Contribution of chloride channels to the action potential and contraction in human myometrium during labour

British Journal of Pharmacology, EarlyView.
Background and purpose The action potential underpinning calcium delivery for contraction in human uterine smooth muscle (myometrium) consists of an initial spike(s) followed by a prolonged plateau of depolarization to ⁓ −25 mV. The plateau duration establishes contraction duration, especially important in labour.
Helena C. Parkington, Ranga E. Siriwardhana, Mary A. Tonta, Shaun P. Brennecke, Penelope M. Sheehan, Marianne Tare, Harold A. Coleman   +6 more
wiley   +1 more source

Characterization of a monoclonal antibody that induces the acrosome reaction of sea urchin sperm. [PDF]

, 1987
A monoclonal antibody, J18/29, induces the acrosome reaction (AR) in spermatozoa of the sea urchin Strongylocentrotus purpuratus. J18/29 induces increases in both intracellular Ca2+ and intracellular pH similar to those occurring upon induction of the AR
Ebina, Y, Meinhof, CG, Schackmann, RW, Trimmer, JS, Vacquier, VD   +4 more
core  

Comparison of four different algorithms for the calculation of radioimmunoassay standard curves [PDF]

, 1980
Peer ...
Herndl, R., Marschner, I., Scriba, Peter Christian   +2 more
core   +2 more sources

Scalable Matrigel‐Free Suspension Culture for Generating High‐Quality Human Liver Ductal Organoids

Cell Proliferation, EarlyView.
A novel matrigel‐free suspension culture enhances the generation of high‐quality human liver ductal organoids, which shows remarkable efficacy in mice transplantation. ABSTRACT Liver transplantation is currently the sole definitive treatment option for end‐stage liver failure.
Senyi Gong, Kangxin He, Yu Liu, Xingyu Luo, Kamran Ashraf, Jinzhao He, Weifeng Li, Lihua Yang, Touseef Ur Rehman, Mingwei Shen, Qinbiao Yan, Ali Mohsin, Shusen Zheng, Zhe Yang, Meijin Guo   +14 more
wiley   +1 more source

Rate-Control or Rhythm-Contol: Where do we stand? [PDF]

, 2005
Atrial fibrillation is the most common sustained rhythm disturbance and its prevalence is increasing worldwide due to the progressive aging of the population.
A, Dello Russo, F, Andreotti, F, Bellocci, G, Pelargonio, G, Trotta, L, Testa, M, Casella   +6 more
core   +1 more source

Beneficial effect of infiltration around the greater occipital nerve in cluster headache independent of modulation of the nociceptive blink reflex

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objectives and Background We aimed to explore the effect of greater occipital nerve (GON) infiltration on trigeminal transmission and its relation to clinical response. Infiltration of the GON with a local anesthetic and corticosteroids is effective in the treatment of both episodic (ECH) and chronic cluster headache (CCH).
Willemijn C. Naber, Paulien J. van Tilborg, Martijn R. Tannemaat, Marieke Niesters, Marieke D. Hellinga, Roemer B. Brandt, Rolf Fronczek   +6 more
wiley   +1 more source

Factors associated with efficacy of occipital nerve stimulation in medically intractable chronic cluster headache

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Background/Objective Occipital nerve stimulation (ONS) has become an established therapy for medically intractable chronic cluster headache (MICCH), but unfortunately, one third of the patients do not respond satisfactorily. Reliable predictors of treatment success would help physicians improve indication for ONS in MICCH.
Roemer B. Brandt, Casper S. Lansbergen, Linda Kollenburg, Michel D. Ferrari, Frank J. P. M. Huygen, Cecile C. de Vos, Rolf Fronczek, for the Occipital Nerve Stimulation in Medically Intractable Chronic Cluster Headache (ICON) trial study group, M. D. Ferrari, L. A. Wilbrink, I. F. de Coo, P.G.G. Doesborg, E.C. Bartels, E.W. van Zwet, F.J.P.M. Huygen, W. Mulleners, E. Kurt, R.T.M. van Dongen, O.P. Teernstra, P.J.J. Koehler, G.H. Spincemaille, L.A. Wilbrink, F. Wille, K. Burger, J. Haan, E.G.M. Couturier, J.W. Kallewaard, Peter H. Veltink, R. Buschman   +28 more
wiley   +1 more source

Influence of Water Temperature on the MXR Activity and P-glycoprotein Expression in the Freshwater Snail, Physa acuta (Draparnaud, 1805) [PDF]

, 2017
P-glycoprotein (P-gp) mediated multixenobioticresistance (MXR) is a mechanism analogous to multidrug resistance, which has been extensivelycharacterized in mammalian tumours.
Assef, Yanina Andrea, Horak, Cristina Natalia   +1 more
core   +1 more source

Galcanezumab reduces trigeminal nociception and is effective in preclinical models of migraine and trigeminal autonomic cephalalgias

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objectives/Background This study was undertaken to assess the therapeutic efficacy of galcanezumab in preclinical models of migraine and cluster headache and to determine potential shared trigeminovascular mechanisms of action. Galcanezumab is a humanized monoclonal antibody that binds to the neuropeptide calcitonin gene‐related peptide ...
Marta Vila‐Pueyo, Peter J. Goadsby, Kirk W. Johnson, Philip R. Holland   +3 more
wiley   +1 more source

The cardiac work-loop technique:An in vitro model for identifying and profiling drug-induced changes in inotropy using rat papillary muscles [PDF]

, 2020
AJ Taberner, AM Aylin, AW Tank, CW Scott, D Burkhoff, D Mehra, DA Eisner, DM Bers, DR Varma, E Takimoto, FG Spinale, H Lüllman, J Layland, J Layland, J Layland, J Layland, J Layland, J Tallis, JI Schwartz, JJ Lynch, JL Holtzman, JR Blinks, JS Landzberg, K Noguchi, K Sagawa, KC Vinnakota, L Batista, L Brown, L Butler, L Guo, LJ Mellors, M Eichelbaum, M Gharanei, MA Rosic, ME Conolly, MF Peters, MS Parmacek, P Bergson, R Beigel, R Josephson, R Lewis, R Seifert, R Zhang, RA Nishimura, RC Heel, RD Olson, RK Josephson, RM Bell, RS James, T Akera, T Bombardini, T Delhaas, VJ Caiozzo, W Kerns, W Semafuko, WA Catterall, Y Kihara   +56 more
core   +1 more source