Results 61 to 70 of about 80,362 (282)

Influence of verapamil on the pharmacokinetics of oridonin in rats

Pharmaceutical Biology, 2019
Context: Oridonin has been traditionally used in Chinese treatment of various cancers, but its poor bioavailability limits its therapeutic uses. Verapamil can enhance the absorption of some drugs with poor oral bioavailability.
Jing Liu, Ning Zhang, Na Li, Xiaocheng Fan, Ying Li   +4 more
doaj   +1 more source

Verapamil Inhibits Aspergillus Biofilm, but Antagonizes Voriconazole

Journal of Fungi, 2017
The paucity of effective antifungals against Aspergillus and increasing resistance, the recognition of the importance of Aspergillus biofilm in several clinical settings, and reports of verapamil—a calcium channel blocker—efficacy against Candida biofilm
Hasan Nazik, Varun Choudhary, David A. Stevens   +2 more
doaj   +1 more source

Proton Motive Force-Dependent Hoechst 33342 Transport by the ABC Transporter LmrA of Lactococcus lactis [PDF]

, 2005
The fluorescent compound Hoechst 33342 is a substrate for many multidrug resistance (MDR) transporters and is widely used to characterize their transport activity.
Abbreviations ABC, Chen M., Doerrler W. T., Ecker G. F., Gajic O., Haugland R. P., Higuchi R., Ketchum C. J., Kuipers O. P., Lalande M. E., Lanzetta P. A., Lewinson O., Linnett P. E., Lubelski J., Lubelski J., Margolles A., Mazurkiewicz P., Orelle C., Paternostre M. T., Poelarends G. J., Putman M., Sakamoto K., Sambrook J., Shapiro A. B., Shapiro A. B., Shapiro A. B., Shapiro A. B., Sharma S., Steinfels E., Urbatsch I. L., van Veen H. W., van Veen H. W., van Veen H. W., Venter H., Viitanen P., Yu J. L.   +35 more
core   +2 more sources

Impact of organic pollutants on phenotype and gene expression in human breast cancer cells

Journal of Applied Toxicology, EarlyView.
ABSTRACT Human exposure to industrial chemical compounds is widespread and, although often beneficial, prolonged contact may contribute to disease development, including cancer. While many studies have shown organic pollutants (OP) are cytotoxic, few have explored how long‐term exposure alters cell phenotype.
Camila Confortin, Heloisa Amancio, Jessica Zablocki da Luz, Aliciane de Almeida Roque, Tugstênio Lima de Souza, José Eduardo Vargas, Ciro Alberto de Oliveira Ribeiro, Francisco Filipak Neto   +7 more
wiley   +1 more source

Risk factors for carnitine deficiency in critically ill adults: A descriptive cross‐sectional study

Journal of Parenteral and Enteral Nutrition, EarlyView.
Abstract Background Critical illness is a risk factor for carnitine deficiency. Carnitine deficiency may result in serious medical complications and poor clinical outcomes. This study aimed to identify the prevalence and potential predictors of carnitine deficiency.
Jennifer Gordon, Rebecca Brody, Hamed Samavat, Mireille Hamdan, Alexander L. Colonna, Jason B. Young, Laura D. Byham‐Gray   +6 more
wiley   +1 more source

Direct Monitoring of Verapamil Level in Exhaled Breath Condensate Samples [PDF]

Pharmaceutical Sciences, 2019
Background: In this research, an enhanced fluorimetric assay was developed for the direct monitoring of verapamil in exhaled breath condensate (EBC). The method is based on a binding–induced rigidity inside the sodium dodecyl sulfate (SDS) micelle which ...
Fariba Pourkarim, Elaheh Rahimpour, Maryam Khoubnasabjafari, Vahid Jouyban-Gharamaleki, Abolghasem Jouyban   +4 more
doaj   +1 more source

α-Hexylcinnamaldehyde synergistically increases doxorubicin cytotoxicity towards human cancer cell lines [PDF]

, 2016
α-Hexylcinnamaldehyde (HCA), a compound derived from cinnamaldehyde, was evaluated for its potential chemosensitizing ...
DI GIACOMO, Silvia, DI SOTTO, Antonella, El Readi, Mahmoud Zaki, Mazzanti, Gabriela, Wink, Michael   +4 more
core  

Modulation of neural cell membrane conductance by the herbal anxiolytic and antiepileptic drug aswal [PDF]

, 2000
To evaluate the effects of aswal on ionic fluxes and neuronal excitation, we performed extracellular and whole cell patch clamp recordings on CA1 pyramidal neurons of guinea pigs and Long-Evans rats.
Grunze, Heinz, Langosch, J., Loewenich, C. von, Walden, Jörg   +3 more
core   +1 more source

The Method of Forecasting of the Indicators for Drug Reimbursement to Patients with Cardiovascular Diseases in Ukraine [PDF]

, 2019
The aim of the study is to develop a method for forecasting the indicators for drug reimbursement to patients with cardiovascular diseases (CVD) in Ukraine within the framework of the government program “Available medicines”.Materials and methods ...
Kurylenko, Y. (Yuliia), Nazarkina, V. (Viktoriya), Nemchenko, A. (Alla)   +2 more
core   +3 more sources

Predicting Pharmacological Treatment Response in Migraine Using AI/ML: A Scoping Review of the Evidence and Future Directions

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, EarlyView.
ABSTRACT The treatment of migraine is hampered by inter‐individual variability, leading to an inefficient “trial and error” approach. Artificial intelligence (AI) and machine learning (ML) offer a path towards precision medicine by predicting therapeutic outcomes.
Martina Giacon, Salvatore Terrazzino
wiley   +1 more source