Results 81 to 90 of about 76,436 (232)

Management of hypotension in dihydropyridine calcium channel blocker overdose: The role of high‐dose insulin therapy

open access: yesBritish Journal of Clinical Pharmacology, Volume 91, Issue 9, Page 2613-2620, September 2025.
Aims Amlodipine poisoning is a leading cause of cardiovascular medication‐related deaths, commonly managed with high‐dose insulin (HDI) therapy. However, HDI is a vasodilator that is counterproductive in managing vasoplegia. We aim to study HDI therapy in patients with hypotension following dihydropyridine calcium channel antagonist (CCA) overdose ...
Betty S. H. Chan   +3 more
wiley   +1 more source

Dynamics of ABC Transporter P-glycoprotein in Three Conformational States. [PDF]

open access: yes, 2019
We used hydrogen-deuterium exchange mass spectrometry (HDX-MS) to obtain a comprehensive view of transporter dynamics (85.8% sequence coverage) occurring throughout the multidrug efflux transporter P-glycoprotein (P-gp) in three distinct conformational ...
Chang, Geoffrey   +2 more
core   +1 more source

Oxidation of clofibric acid in aqueous solution using a non-thermal plasma discharge or gamma radiation

open access: yes, 2017
In this work, we study degradation of clofibric acid (CFA) in aqueous solution using either ionizing radiation from a $^{60}$Co source or a non-thermal plasma produced by discharges in the air above the solution.
Ceriani, Elisa   +7 more
core   +1 more source

Comprehensive Qualitative Drug Screening in Emergency Toxicology Using an Automated LC–MSn System:Simultaneous Quantification of Relevant Drugs and Metabolites in Blood Plasma

open access: yesDrug Testing and Analysis, Volume 17, Issue 9, Page 1502-1515, September 2025.
Simultaneous qualitative and quantitative analysis of 62 drugs and seven active metabolites in human blood plasma by automated liquid chromatography linear ion trap mass spectrometry. ABSTRACT Rapid and comprehensive qualitative and quantitative analytical procedures are crucial in 24/7 emergency toxicology (ET) to support diagnosis and treatment of ...
Selina Hemmer   +4 more
wiley   +1 more source

Verapamil in diabetes

open access: yesIndian Journal of Endocrinology and Metabolism, 2017
Nisha Kusum Kafle, Resham Raj Poudel
openaire   +4 more sources

Mapping Glial Autophagy Dynamics in an Amyotrophic Lateral Sclerosis Mouse Model Reveals Microglia and Astrocyte Autophagy Dysfunction

open access: yesGlia, Volume 73, Issue 9, Page 1860-1882, September 2025.
Main Points In SOD1 mice: Symptomatic spinal microglia and astrocytes show increased autophagy flux with greaten dysfunction and 3OD1 inclusions in astrocytes. Dystunction was transient (end stage glia displayed control comparable levels of autophagy parameters)‐ ABSTRACT Amyotrophic lateral sclerosis (ALS) is defined by motor neuron death.
Nirma D. Perera   +4 more
wiley   +1 more source

A Conceptual Review of Naturally Occurring Toxins and Venoms as Peptide Blockers to Combat Chronic Low Back Pain

open access: yesJOR SPINE, Volume 8, Issue 3, September 2025.
This review explores the therapeutic potential of naturally occurring venom‐derived peptides, particularly from reptiles and insects, as novel calcium channel blockers for managing chronic low back pain caused by intervertebral disc degeneration.
James Melrose   +4 more
wiley   +1 more source

Pacemapping [PDF]

open access: yes, 2005
Pacemapping (PM) is an electrophysiologic technique designed to help locating tachycardia sources by stimulating at different endocardial sites in order to reproduce the clinical tachycardia characteristics.
Moreno, Mauricio   +2 more
core   +2 more sources

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