Results 81 to 90 of about 78,658 (276)
A quad‐cistronic fluorescent biosensor system for real‐time detection of subcellular Ca2+ signals
British Journal of Pharmacology, EarlyView.Background and Purpose The calcium ion (Ca2+) is a versatile cellular messenger regulating a variety of biological processes. Compounds modulating subcellular Ca2+ signals hold substantial pharmacological potential. Advances in fluorescent biosensors have revolutionised Ca2+ imaging.
Anna Lischnig +7 more
wiley +1 more source
Frequency Analysis of Atrial Fibrillation From the Surface Electrocardiogram [PDF]
, 2004 Atrial fibrillation (AF) is the most common arrhythmia encountered in clinical practice. Neither the natural history of AF nor its response to therapy are sufficiently predictable by clinical and echocardiographic parameters.
Bollmann, Andreas +4 more
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Influence of Water Temperature on the MXR Activity and P-glycoprotein Expression in the Freshwater Snail, Physa acuta (Draparnaud, 1805) [PDF]
, 2017 P-glycoprotein (P-gp) mediated multixenobioticresistance (MXR) is a mechanism analogous to multidrug resistance, which has been extensivelycharacterized in mammalian tumours.
Assef, Yanina Andrea +1 more
core +1 more source
Clinical Otolaryngology, EarlyView.ABSTRACT Objective Identify and summarise the evidence on the efficacy of low‐dose verapamil use for adult patients with Chronic Rhinosinusitis with Nasal Polyps (CRSwNP). Methods Two reviewers independently searched the data sources until the 28th of December 2023.
Fangxing Yin +3 more
wiley +1 more source
International Journal of Hepatology, 2020 Paracetamol, chemically known as acetaminophen, if taken in higher doses has hepatotoxic potential. Cimetidine by inhibiting the cytochromal enzymes and reducing the production of the toxic metabolite can reduce the hepatotoxic potential while Verapamil ...
Lubna Danish +5 more
doaj +1 more source
The alternate GNB3 splice variant, Gβ3s, exhibits an altered signalling response to EGF stimulation, which leads to enhanced cell migration [PDF]
, 2013 It has recently been reported that the duplication of the GNB3 gene has been shown to be directly linked to an obesity phenotype, both in humans and also in a humanised mouse model. Moreover, the common human GNB3 c.825C>T polymorphism (rs5443) causes
D’Ascanio, Isabella +7 more
core +5 more sources
Headache: The Journal of Head and Face Pain, EarlyView.Abstract Objectives and Background We aimed to explore the effect of greater occipital nerve (GON) infiltration on trigeminal transmission and its relation to clinical response. Infiltration of the GON with a local anesthetic and corticosteroids is effective in the treatment of both episodic (ECH) and chronic cluster headache (CCH).
Willemijn C. Naber +6 more
wiley +1 more source
Neoplasia: An International Journal for Oncology Research, 2010 The proteasome inhibitor bortezomib is clinically approved for the treatment of multiple myeloma. However, long-term remissions are difficult to achieve, and myeloma cells often develop secondary resistance to proteasome inhibitors.
Silke Meister +6 more
doaj +1 more source
Headache: The Journal of Head and Face Pain, EarlyView.Abstract Objectives/Background This study was undertaken to assess the therapeutic efficacy of galcanezumab in preclinical models of migraine and cluster headache and to determine potential shared trigeminovascular mechanisms of action. Galcanezumab is a humanized monoclonal antibody that binds to the neuropeptide calcitonin gene‐related peptide ...
Marta Vila‐Pueyo +3 more
wiley +1 more source
, 2004 Hypertension is a rapidly moving clinical field with frequent developments in new pharmacologic agents and management strategies. Perhaps more importantly, there have been substantial improvements in our understanding of how best to use the drugs ...
Farrugia, Emanuel
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