Results 81 to 90 of about 101,449 (340)

Identification of side population cells in mouse primordial germ cells and prenatal testis [PDF]

, 2011
In mammals, the stem cells of spermatogenesis are derived from an embryonic cell population called primordial germ cells (PGCs). Spermatogonial stem cells displaying the "side population" (SP) phenotype have been identified in the immature and adult ...
De Felici, Massimo, Fera, Stefania, Grisanti, Laura, Lucia Scaldaferri, Maria, Sanchez, Massimo, Stefanini, Mario, Vicini, Elena   +6 more
core   +2 more sources

Variability in intestinal drug metabolizing enzymes and transporters in Crohn's disease and potential impact on oral drug absorption

British Journal of Clinical Pharmacology, EarlyView.
Aims The aim of study was to generate quantitative data on the abundance of drug‐metabolizing enzymes and transporters (DMETs) in inflamed and non‐inflamed Crohn's disease (CD) ileum and colon, for incorporation into physiologically based pharmacokinetic (PBPK) models, enabling prediction of oral drugs' pharmacokinetics (PK) perturbation in CD patients.
Sarah Alrubia, Brahim Achour, Zubida M. Al‐Majdoub, Amin Rostami‐Hodjegan, Jill Barber   +4 more
wiley   +1 more source

Approaching complete inhibition of P-glycoprotein at the human blood–brain barrier: an (R)-[11C]verapamil PET study

Journal of Cerebral Blood Flow and Metabolism, 2015
As P-glycoprotein (Pgp) inhibition at the blood–brain barrier (BBB) after administration of a single dose of tariquidar is transient, we performed positron emission tomography (PET) scans with the Pgp substrate (R)-[11C]verapamil in five healthy ...
M. Bauer, R. Karch, M. Zeitlinger, C. Philippe, Kerstin Römermann, J. Stanek, A. Maier‐Salamon, W. Wadsak, W. Jäger, M. Hacker, Markus Müller, O. Langer   +11 more
semanticscholar   +1 more source

Endovascular Treatment of Malfunctioning Dialysis Fistulas: A Multicenter Retrospective Analysis Comparing Transradial and Conventional Transvenous Access

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Venous outflow is the favored access for endovascular management of dialysis fistulas. However, transradial access (TRA) offers advantages in specific clinical scenarios. The study aims to compare the efficacy, feasibility, and safety of TRA and transvenous access (TVA) in the endovascular management of malfunctioning dialysis ...
Roberto Minici, Massimo Venturini, Federico Fontana, Giuseppe Guzzardi, Federico Torre, Marco Spinetta, Andrea Coppola, Filippo Piacentino, Pasquale Guerriero, Nicola De Rosi, Biagio Apollonio, Marco Franchin, Francesco Giurazza, MGJR Research Team, Luca Brunese, Domenico Laganà   +15 more
wiley   +1 more source

Verapamil Induces Calcium Influx in the Trachea

Journal of Pharmacological Sciences, 2008
Verapamil, a Ca2+entry blocker, can induce bronchorelaxation and bronchoconstriction. The mechanism of verapamil-induced bronchoconstriction is poorly understood.
Seham Mustafa, Abdulkareem Abdulraheem, Abdulhakeem Alsughayer   +2 more
doaj  

Short-Term Effects of Verapamil and Diltiazem in the Treatment of No Reflow Phenomenon: A Meta-Analysis of Randomized Controlled Trials

BioMed Research International, 2015
Currently, there is still a lack of an optimal treatment for no reflow phenomenon (NRP). We analyzed the efficacy and safety of using nondihydropyridine calcium channel antagonists (NDHP, verapamil/diltiazem) in patients suffering from NRP.
Lan Wang, Zhong Cheng, Ye Gu, Dingfeng Peng   +3 more
semanticscholar   +1 more source

Ventricular Tachycardia in the Absence of Structural Heart Disease [PDF]

, 2005
In up to 10% of patients who present with ventricular tachycardia (VT), obvious structural heart disease is not identified. In such patients, causes of ventricular arrhythmia include right ventricular outflow tract (RVOT) VT, extrasystoles, idiopathic ...
Appleton, Christopher P, Lester, Steven J, Munger, Thomas M, Scott, Luis R P, Srivathsan, Komandoor   +4 more
core   +1 more source

Verapamil Attenuates the Severity of Tendinopathy by Mitigating Mitochondrial Dysfunction through the Activation of the Nrf2/HO-1 Pathway

Biomedicines
Tendinopathy is a prevalent condition in orthopedics patients, exerting a profound impact on tendon functionality. However, its underlying mechanism remains elusive and the efficacy of pharmacological interventions continues to be suboptimal.
Zengguang Wang, Zhenglin Dong, Yiming Li, Xin Jiao, Yihao Liu, Hanwen Chang, Yaokai Gan   +6 more
doaj   +1 more source

Synthesis and pharmacological investigation of new N-hydroxyalkyl-2-aminophenothiazines exhibiting marked MDR inhibitory effect [PDF]

, 2013
Novel N-hydroxyalkyl-2-aminophenothiazines implying a tetrazole moiety at the alkyl chain have been synthesized by hydroboration-oxidation of dienes followed by Buchwald-Hartwig cross-coupling reaction.
Agnelli, Babudri, Bourquin, Craig, Daniella Takács, Ferry, Garbaccio, Gatti, Gilman, Gilman, Gritsenko, Guram, György Hajós, Hu, József Molnár, Júlia Visy, Katalin Jemnitz, Kiss, Leslie, László Drahos, McKillop, Mofaddel, Mónika Szabó, Nagy, Orsolya Egyed, Petersen, Pluta, Pope, Pál Szabó, Seglen, Shukla, Takács, Takács, Thomas, Tiwari, Tosa, Whitney, Xu, Zsuzsa Veres, Zsuzsanna Riedl   +39 more
core   +1 more source

The clinically approved drugs amiodarone, dronedarone and verapamil inhibit filovirus cell entry

Journal of Antimicrobial Chemotherapy, 2014
Objectives Filoviruses such as Ebola virus and Marburg virus cause a severe haemorrhagic fever syndrome in humans for which there is no specific treatment.
Gerrit Gehring, K. Rohrmann, N. Atenchong, E. Mittler, S. Becker, F. Dahlmann, S. Pöhlmann, F. Vondran, S. David, M. Manns, S. Ciesek, T. von Hahn   +11 more
semanticscholar   +1 more source