Results 181 to 190 of about 15,922 (221)
Versican and Versican-matrikines in Cancer Progression, Inflammation, and Immunity
Journal of Histochemistry and Cytochemistry, 2020 Versican is an extracellular matrix proteoglycan with key roles in multiple facets of cancer development, ranging from proliferative signaling, evasion of growth-suppressor pathways, regulation of cell death, promotion of neoangiogenesis, and tissue invasion and metastasis.
Athanasios Papadas +2 more
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Versican in the Tumor Microenvironment
2020Versican is an extracellular matrix proteoglycan with nonredundant roles in diverse biological and cellular processes, ranging from embryonic development to adult inflammation and cancer. Versican is essential for cardiovascular morphogenesis, neural crest migration, and skeletal development during embryogenesis.
Athanasios, Papadas +1 more
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Versican expression in human cervical cancer
European Journal of Cancer, 2007Versican expression may enhance tumour invasion and metastasis. However, the expressions of versican in cervical cancer have seldom been characterised. The aim of this study was to investigate versican expression in human cervical cancers. We immunohistochemically investigated the expression of versican protein in 174 cervical cancers and analysed the ...
J, Kodama +7 more
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V3: an enigmatic isoform of the proteoglycan versican
American Journal of Physiology-Cell Physiology, 2023V3 is an isoform of the extracellular matrix (ECM) proteoglycan (PG) versican generated through alternative splicing of the versican gene such that the two major exons coding for sequences in the protein core that support chondroitin sulfate (CS) glycosaminoglycan (GAG) chain attachment are excluded. Thus, versican V3 isoform carries no GAGs. A survey
Thomas N. Wight +10 more
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Versican modulates gap junction intercellular communication
Journal of Cellular Physiology, 2007AbstractVersican is a large chondroitin sulfate proteoglycan and belongs to the family of lecticans. Versican possesses two globular domains, G1 and G3 domain, separated by a CS‐attachment region. The CS‐attachment region present in the middle region is divided into two spliced domains named CSα and β.
Wang, Sheng +4 more
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Versican in human fetal skin development
Anatomy and Embryology, 1999The extracellular matrix of human fetal skin differs substantially from that of adult skin. Fetal skin contains sparse amounts of fibrillar collagen enmeshed in a highly hydrated amorphous matrix composed of hyaluronan and sulfated proteoglycans. Both fetal and adult skin contain two major interstitial proteoglycans that are extracted by chaotrophic ...
J M, Sorrell +3 more
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Versican in Health and Disease
Connective Tissue Research, 2008Versican is a component of the extracellular matrix, which interacts with several matrix and cell surface molecules. Versican plays central roles in tissue morphogenesis and homeostasis and is implicated in the development of numerous diseases. The expression of versican by multiple cell types is differentially regulated in a temporal and spatial ...
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Aggrecan and versican: two brothers close or apart
American Journal of Physiology-Cell Physiology, 2022Aggrecan (Acan) and versican (Vcan) are large chondroitin sulfate proteoglycans of the extracellular matrix. They share the same structural domains at both N- and C-termini. The N-terminal G1 domain binds hyaluronan (HA), forms an HA-rich matrix, and regulates HA-mediated signaling.
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T-cell responses to versican in ankylosing spondylitis
Rheumatology International, 2009The objective of our study was to undertake a systematic analysis of the T-cell response to the proteoglycan versican G1-globular domain (VG1) in ankylosing spondylitis (AS) as immunity to VG1 in mice can induce a pathology closely resembling AS. Peripheral blood lymphocytes from 36 AS patients and 33 healthy controls were incubated with recombinant ...
Tae-Jong, Kim +5 more
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Versican: Role in Cancer Tumorigenesis
2017Versican is an extracellular matrix proteoglycan that is expressed in a wide variety of cancers. Several cellular sources for versican have been identified in a multitude of cancers including tumor cells, stromal cells, myeloid cells, and lymphoid cells.
Paul A. Keire +2 more
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