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ADAMTS4 Reduction Contributes to Extracellular Matrix Deposition and Impaired Myogenesis in the Skeletal Muscle of Cigarette Smoke-Exposed Mice. [PDF]
BiomedicinesLi D +5 more
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Versican binds collagen via its G3 domain and regulates the organization and mechanics of collagenous matrices. [PDF]
J Biol ChemChen D +7 more
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Versican in Health and Disease
Connective Tissue Research, 2008Versican is a component of the extracellular matrix, which interacts with several matrix and cell surface molecules. Versican plays central roles in tissue morphogenesis and homeostasis and is implicated in the development of numerous diseases. The expression of versican by multiple cell types is differentially regulated in a temporal and spatial ...
Achilleas Theocharis
exaly +3 more sources
Versican expression in human cervical cancer
European Journal of Cancer, 2007Versican expression may enhance tumour invasion and metastasis. However, the expressions of versican in cervical cancer have seldom been characterised. The aim of this study was to investigate versican expression in human cervical cancers. We immunohistochemically investigated the expression of versican protein in 174 cervical cancers and analysed the ...
J Kodama, A Hongo, Y Hiramatsu
exaly +3 more sources
Versican localizes to the nucleus in proliferating mesenchymal cells
Cardiovascular Pathology, 2015Versican is a versatile and highly interactive chondroitin sulfate proteoglycan that is found in the extracellular matrix (ECM) of many tissues and is a major component of developing and developed lesions in atherosclerotic vascular disease. In this paper, we present data to indicate that versican may have important intracellular functions in addition ...
Thomas Abraham, Anna Meredith
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The biological role and regulation of versican levels in cancer
Cancer and Metastasis Reviews, 2009 Increased expression of the proteoglycan, versican is strongly associated with poor outcome for many different cancers. Depending on the cancer type, versican is expressed by either the cancer cells themselves or by stromal cells surrounding the tumor ...
Carmela Ricciardelli +2 more
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V3: an enigmatic isoform of the proteoglycan versican
American Journal of Physiology-Cell Physiology, 2023V3 is an isoform of the extracellular matrix (ECM) proteoglycan (PG) versican generated through alternative splicing of the versican gene such that the two major exons coding for sequences in the protein core that support chondroitin sulfate (CS) glycosaminoglycan (GAG) chain attachment are excluded. Thus, versican V3 isoform carries no GAGs. A survey
Thomas N. Wight +10 more
openaire +2 more sources
Versican in the Tumor Microenvironment
2020Versican is an extracellular matrix proteoglycan with nonredundant roles in diverse biological and cellular processes, ranging from embryonic development to adult inflammation and cancer. Versican is essential for cardiovascular morphogenesis, neural crest migration, and skeletal development during embryogenesis.
Athanasios, Papadas +1 more
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Versican in human fetal skin development
Anatomy and Embryology, 1999The extracellular matrix of human fetal skin differs substantially from that of adult skin. Fetal skin contains sparse amounts of fibrillar collagen enmeshed in a highly hydrated amorphous matrix composed of hyaluronan and sulfated proteoglycans. Both fetal and adult skin contain two major interstitial proteoglycans that are extracted by chaotrophic ...
J M, Sorrell +3 more
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