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Versican Promotes Cardiomyocyte Proliferation and Cardiac Repair
CirculationBACKGROUND: The adult mammalian heart is incapable of regeneration, whereas a transient regenerative capacity is maintained in the neonatal heart, primarily through the proliferation of preexisting cardiomyocytes. Neonatal heart regeneration after myocardial injury is accompanied by an expansion of cardiac fibroblasts and ...
Jie Feng +16 more
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Perspectives on developmental neurobiology, 1997
Proteoglycans have long been recognized as participating in a number of biological activities ranging from structural roles to regulation of transcription. Versican is a large chondroitin sulfate proteoglycan expressed in several tissues, including the nervous system.
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Proteoglycans have long been recognized as participating in a number of biological activities ranging from structural roles to regulation of transcription. Versican is a large chondroitin sulfate proteoglycan expressed in several tissues, including the nervous system.
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Versican protects cells from oxidative stress-induced apoptosis
Matrix Biology, 2005Oxidant injury plays a critical role in the degenerative changes that are characterized by a decline in parenchymal cell numbers and viability, and occur with aging and in the etiology of many diseases. The extracellular proteoglycan versican is widely distributed in the extracellular matrix surrounding the cells.
Yaojiong, Wu +7 more
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Hyaluronan, CD44 and versican in epidermal keratinocyte tumours
British Journal of Dermatology, 2003The high molecular weight polysaccharide hyaluronan is a major component of the extracellular matrix between the vital cells of human skin epidermis. The levels of hyaluronan, and those of the hyaluronan receptor CD44 and the hyaluronan binding proteoglycan versican, correlate with the aggressiveness of different human carcinomas of epithelial origin ...
S, Karvinen +3 more
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Glycosaminoglycan and versican deposits in taxane-induced sclerosis
British Journal of Dermatology, 2015Docetaxel and paclitaxel are widely used in the treatment of various malignant neoplasms. Taxane-induced sclerosis is dose-dependent and usually not generalized. Little information on the pathogenesis of scleroderma is currently available. Here, we report a case of generalized scleroderma and a case of early-stage oedematous sclerosis, both of which ...
K. Okada +5 more
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Atherosclerosis, 2001
Abdominal aortic aneurysm (AAA) is a common disease of human aorta with increased incidence. It is a complication to atherosclerosis and it is closely associated with alterations in extracellular macromolecules. In this study, the levels of mRNA for versican--the major extracellular arterial proteoglycan (PG)--present in AAA and normal aortas were ...
A D, Theocharis +3 more
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Abdominal aortic aneurysm (AAA) is a common disease of human aorta with increased incidence. It is a complication to atherosclerosis and it is closely associated with alterations in extracellular macromolecules. In this study, the levels of mRNA for versican--the major extracellular arterial proteoglycan (PG)--present in AAA and normal aortas were ...
A D, Theocharis +3 more
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Versican overexpression in cutaneous malignant melanoma.
European journal of medical research, 2009Tumor growth regulation by extracellular matrix components has been one of the main topics on tumor biology in the last years. We aimed to investigate the protein expression pattern of decorin and versican in superficial spreading melanoma (SSM) and its precursors.Paraffin-embedded sections of benign nevi (BN), dysplastic nevi (DN), and primary SSM ...
Thilo, Gambichler +5 more
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Versican: signaling to transcriptional control pathways.
Canadian journal of physiology and pharmacology, 2006Versican, a chondroitin sulfate proteoglycan, is one of the main components of the extracellular matrix, which provides a loose and hydrated matrix during key events in development and disease. Versican participates in cell adhesion, proliferation, migration, and angiogenesis, and hence plays a central role in tissue morphogenesis and maintenance.
Maziar, Rahmani +6 more
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