Results 111 to 120 of about 144,497 (249)

Synthetic Toll‐Like Receptors for Control of Innate Immunity With Far‐Red Light

Advanced Science, EarlyView.
Synthetic Toll‐like receptors (TLRs) are engineered by replacing their natural sensing regions with a far‐red‐light‐responsive module from a bacterial phytochrome. These synthetic receptors enable light‐controlled regulation of immune signaling in mammalian cells.
Anna V. Leopold, Vladislav V. Verkhusha
wiley   +1 more source

Substantial Fat Loss in Physique Competitors Is Characterized by Increased Levels of Bile Acids, Very-Long Chain Fatty Acids, and Oxylipins. [PDF]

Metabolites, 2022
Sarin HV, Hulmi JJ, Qin Y, Inouye M, Ritchie SC, Cheng S, Watrous JD, Nguyen TC, Lee JH, Jin Z, Terwilliger JD, Niiranen T, Havulinna A, Salomaa V, Pietiläinen KH, Isola V, Ahtiainen JP, Häkkinen K, Jain M, Perola M.   +19 more
europepmc   +1 more source

Iron‐Mediated Release of Aged Dissolved Organic Carbon From Waterlogged Peatland Under Warming

Advanced Science, EarlyView.
This study conducts a five‐year in situ warming experiment in high‐altitude peatlands to examine dissolved organic carbon (DOC) release. The study shows that warming promotes the release of plant‐derived modern DOC in drained peatlands, but amplifies aquatic export of century‐old DOC from waterlogged peatlands via Fe‐mediated DOC mobilization—a ...
Guohua Dai, Zhiying Yang, Zongguang Liu, Wanjia Hu, Lixiao Ma, Enze Kang, Wanqing Luo, Yunpeng Zhao, Chengzhu Liu, Juan Jia, Ting Liu, Chen He, Quan Shi, Jianliang Liu, Yongheng Gao, Huai Chen, Hailong Zhang, Meixun Zhao, Xiaojuan Feng   +18 more
wiley   +1 more source

Association between the circulating very long-chain saturated fatty acid and cognitive function in older adults: findings from the NHANES

BMC Public Health
Background Age-related cognitive decline has a significant impact on the health and longevity of older adults. Circulating very long-chain saturated fatty acids (VLSFAs) may actively contribute to the improvement of cognitive function.
Yanxin Shen, Chunxiao Wei, Yezi Taishi, Guimei Zhang, Zhan Su, Panpan Zhao, Yongchun Wang, Mingxi Li, Yingshi Ji, Li Sun   +9 more
doaj   +1 more source

Glycosphingolipids with Very Long-Chain Fatty Acids Accumulate in Fibroblasts from Adrenoleukodystrophy Patients. [PDF]

Int J Mol Sci, 2021
Fujiwara Y, Hama K, Shimozawa N, Yokoyama K.   +3 more
europepmc   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

False-positive very long-chain fatty acids in a case of autoimmune adrenal insufficiency. [PDF]

J Pediatr Endocrinol Metab, 2021
Zhu J, Breault DT.
europepmc   +1 more source

Integrative Multi‐Omics Analysis Reveals a Mitochondrial–Immune Axis Associated With Neoadjuvant Chemotherapy Response in High‐Grade Serous Ovarian Cancer

Advanced Science, EarlyView.
Integrative multi‐omics analysis delineates a mitochondrial–immune axis governing neoadjuvant chemotherapy response in high‐grade serous ovarian cancer. Immune‐active tumors exhibit enhanced B‐cell infiltration and favorable sensitivity, whereas metabolically rewired tumors display oxidative phosphorylation dependency and resistance.
Wei Jiang, Yi Wang, Xiaohang Lu, Qianlan Yao, Libing Xiang, Xu Cai, Xiaoyu Tu, Shaoxian Tang, Ying Xu, Yufan Cheng, Liming Shen, Huijuan Yang   +11 more
wiley   +1 more source

A Specific microRNA Targets an Elongase of Very Long Chain Fatty Acids to Regulate Fatty Acid Composition and Mitochondrial Morphology of Skeletal Muscle Cells. [PDF]

Animals (Basel), 2022
Wang H, Hu M, Shen Z, Zhou X, Yang S, He K, Li X, Yan F, Zhao A.   +8 more
europepmc   +1 more source

A Molecular Engineering Strategy to Fine‐Tune Phototoxicity of AIE Probes for Super‐Resolution Imaging of Mitochondrial Cristae Dynamics

Advanced Science, EarlyView.
Regulation of molecular packing, phototoxicity, and ROS output of AIE photosensitizers is achieved through carboxylation and alkyl‐chain‐length tuning. The probe designed via this strategy enables super‐resolution visualization of inner‐mitochondrial‐membrane cristae dynamics under controlled oxidative stress, and fluorescence‐lifetime imaging of ...
Kongqi Chen, Mengjie Wang, Chuen Kam, Zhiming Wang, Qinrong Zhang, Sijie Chen   +5 more
wiley   +1 more source