Results 51 to 60 of about 164,812 (264)

Apolipoprotein B and triacylglycerol secretion in human triacylglycerol hydrolase transgenic mice

Journal of Lipid Research, 2007
Apolipoprotein B (apoB)-containing lipoproteins play a critical role in whole body lipid homeostasis and the pathogenesis of atherosclerosis. The assembly of hepatic apoB-containing lipoproteins, VLDL, is governed by the availability of lipids, including
Enhui Wei, Mustafa Alam, Fengcheng Sun, Luis B. Agellon, Dennis E. Vance, Richard Lehner   +5 more
doaj   +1 more source

Oral Dosed Organo‐Silica Nanoparticles Restore Glucose Homeostasis and β‐Cell Function in Diabetes Rats

Advanced Functional Materials, EarlyView.
An oral nanoplatform, MOP@T@D, which can maintain glucose homeostasis and restore islet β cells in diabetic rats is developed. It achieves efficient intestinal absorption and liver‐targeted delivery. The nanoparticle disintegrates only in response to hyperglycemia to release insulin on demand and provides antioxidant protection through selenoprotein ...
Chenxiao Chu, Mingli Wei, Che Bian, Xiaoshuang Bi, Yaxin Deng, Peifu Xiao, Jiansong Zhao, Yuying Wang, Haibing He, Jingxin Gou, Tian Yin, Xing Tang, Li Yang, Hongbo Zhang, Yu Zhang   +14 more
wiley   +1 more source

"EFFECT OF PROGESTERONE AND LOVASTATIN ON THE SECRETION OF VERY LOW DENSITY LIPOPROTEIN 1 AND 2 IN THE NORMAL GUINEA PIG MODEL" [PDF]

Acta Medica Iranica, 2004
Liver secretes a large range of very low density lipoprotein (VLDL) particles of different sizes and Svedberg flotation rates (Sf). In plasma VLDL is converted to low density lipoprotein (LDL)which in turn plays an important role in the development of ...
F. Asadi Jamnani, M. Doosti, M. Zahraei, M. Ghazi Sh. Ahmadian   +3 more
doaj   +2 more sources

The effects of non-nutritive sweeteners on lipid profile in adults: a systematic review and meta-analysis of randomized controlled clinical trials

Scientific Reports
Non-nutritive sweeteners (NNS) have been suggested as a viable solution to reduce sugar consumption. However, conflicting and uncertain evidence regarding their impact on lipid profile exists. This meta-analysis assesses the effects of different types of
AmirHossein Najafi, Fatemeh Moghtaderi, Behnaz Seyedjafari, Kimia Rostampour, Amin Salehi-Abargouei   +4 more
doaj   +1 more source

Hepatic triglyceride lipase promotes low density lipoprotein receptor-mediated catabolism of very low density lipoproteins in vitro

Journal of Lipid Research, 1999
We demonstrate here that hepatic triglyceride lipase (HTGL) enhances VLDL degradation in cultured cells by a LDL receptor-mediated mechanism. VLDL binding at 4°C and degradation at 37°C by normal fibroblasts was stimulated by HTGL in a dose-dependent ...
Jheem D. Medh, Susan L. Bowen, Glenna L. Fry, Stacie Ruben, John Hill, Howard Wong, David A. Chappell   +6 more
doaj   +1 more source

Generation of an Induced Pluripotent Stem Cell‐Derived Alveolar Type II In Vitro Model to Study Influenza A Virus Infection and Drug Treatments

Advanced Healthcare Materials, EarlyView.
Patient‐specific induced pluripotent stem cells (iPSCs) can be differentiated into alveolar type II cells (iAT2s), expanded as 3D alveolospheres, and grown at physiologically relevant air–liquid interface (ALI). This study shows for the first time the infectability of iAT2s by the influenza A virus (IAV) and proves their responsiveness to the well ...
Lena Gauthier, Hristina Koceva, Yann Bachelot, Rosanne W. Koutstaal, Puck B. van Kasteren, Marc Thilo Figge, Christian Eggeling, Alexander Sandy Mosig   +7 more
wiley   +1 more source

A Heparin‐Functionalized Scaffold with HB‐EGF Immobilization for Tissue Engineering

Advanced Healthcare Materials, EarlyView.
In this study, a heparin‐functionalized scaffold is designed for bio‐mimicking growth factors reservoir function of extracellular matrix. Due to the presence of heparin‐binding domain, heparin‐binding epidermal growth factor‐like growth factor (HB‐EGF) is effectively and spatially captured by heparin‐functionalized scaffold.
Bowu Peng, Huajian Chen, Chengyu Lu, Tianjiao Zeng, Man Wang, Toru Yoshitomi, Naoki Kawazoe, Yingnan Yang, Guoping Chen   +8 more
wiley   +1 more source

Characterization of very low density lipoprotein from Watanabe heritable hyperlipidemic rabbits.

Journal of Lipid Research, 1989
We investigated the properties of very low density lipoprotein (VLDL) from two types of Watanabe heritable hyperlipidemic (WHHL) rabbits: one with a high incidence of coronary atherosclerosis (type 1), and the other with a low incidence (type 2).
K Ishii, T Kita, M Yokode, N Kume, Y Nagano, H Otani, T Yamamura, S Murayama, Y Morimoto, Y Teranishi   +9 more
doaj   +1 more source

Strategies to Improve the Lipophilicity of Hydrophilic Macromolecular Drugs

Advanced Healthcare Materials, EarlyView.
Hydrophilic macromolecular drugs can be successfully lipidized by covalent attachment of lipids, by hydrophobic ion pairing with negatively or positively charged surfactants, and by dry or wet reverse micelle formation. Lipophilicity enhancement of hydrophilic macromolecules has several benefits including stability and bioavailability improvement ...
Sera Lindner, Stefan Keim, Soheil Haddadzadegan, Odile Fernandez Romero, Katrin Zöller, Gabriel Stern, Ilaria Cesi, Krum Kafedjiiski, Andreas Bernkop‐Schnürch   +8 more
wiley   +1 more source

Characterization of Chicken Portomicron Remnant and Very Low Density Lipoprotein Remnant

The Journal of Poultry Science, 2009
Portomicron remnant and very low density lipoprotein (VLDL) remnant in chickens were prepared by the method using ultracentrifugation (d<1.019) following an in vitro incubation of portomicron or VLDL prepared from chicken plasma with chicken ...
Kan Sato, Katsumi Suzuki, Yukio Akiba
doaj   +1 more source