Results 171 to 180 of about 152,465 (288)

Multi-omics study identifies that PICK1 deficiency causes male infertility by inhibiting vesicle trafficking in Sertoli cells. [PDF]

Reprod Biol Endocrinol, 2023
Jin J, Li K, Du Y, Gao F, Wang Z, Li W.
europepmc   +1 more source

Light‐Harvesting Photothermal Hotspots Enabled by NIR Scattering‐Absorption Coupling

Advanced Science, EarlyView.
By coupling the broadband scattering of nanodiamonds with the plasmonic absorption of gold nanostars, this work proposes a novel strategy for the active modulation of photon transport. This strategy creates localized photothermal hotspots in turbid media and achieves a supra‐additive heating efficiency, thereby providing a universal platform for low ...
Zebin Wu, Changming Bao, Pengyu Zhang, Tao Ding, Weiming Lin, Haodong Li, Wenjian Luo, Xizhi Deng, Hao Wang, Guanle Li, Hongyue Hu, Ye Wang, Dawei Jiang, Yu Zhang, Sisi Jia, Nan Zhang, Min Ke, Le Liang   +17 more
wiley   +1 more source

Glycolipid transfer protein knockout disrupts vesicle trafficking to the plasma membrane. [PDF]

J Biol Chem, 2023
Nurmi H, Backman APE, Halin J, Lönnfors M, Blom T, Roos-Mattjus P, Mattjus P.   +6 more
europepmc   +1 more source

Divergent Roles of mGlu2 and mGlu3 Receptors in Amyloid‐β Production and Cognitive Dysfunctions in Alzheimer's Disease

Advanced Science, EarlyView.
This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon, Mireille Elodie Tsitokana, Ugo Guy Alenda, Yen‐Ling Lian, Clémentine Eva Philibert, Mathieu Oosterlaken, Marta Cimadevila, Gaëlle Dudon, Jessica Monnic, Salomé Roux, Julie Bessié, Séverine Diem, Franck Vandermoere, Laurent Prézeau, Patrick Chames, Julie Kniazeff, Sylvie Claeysen, Anaïs Menny, Jean‐Philippe Pin, Véronique Perrier, Jianfeng Liu, Philippe Rondard   +21 more
wiley   +1 more source

Vesicle-Trafficking Protein SEC22b [PDF]

, 2020
openaire   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Disruption of Synaptic Vesicle Trafficking in Alzheimer's and Parkinson's Disease: Mechanisms and Therapeutic Implication. [PDF]

Int J Mol Sci
Zhu Y, Zhao L, Li Y, Tian M, Liao Y, Huang J, Guo P, Xie Y.   +7 more
europepmc   +1 more source

Simultaneously targeting extracellular vesicle trafficking and TGF-β receptor kinase activity blocks signaling hyperactivation and metastasis. [PDF]

Signal Transduct Target Ther, 2023
Teixeira AF, Wang Y, Iaria J, Ten Dijke P, Zhu HJ.   +4 more
europepmc   +1 more source

PAIR: Reconstructing Single‐Cell Open‐Chromatin Landscapes for Transcription Factor Regulome Mapping

Advanced Science, EarlyView.
scATAC‐seq analysis is often constrained by limited sequencing depth, extreme sparsity, and pervasive technical missingness. PAIR is a probabilistic framework that restores scATAC‐seq accessibility profiles by directly modeling the native cell–peak bipartite structure of chromatin accessibility.
Yanchi Su, Qi Qi, Yi Fan, Yubo Wang, Gaoyang Hao, Ka‐Chun Wong, Yunhe Wang, Xiangtao Li   +7 more
wiley   +1 more source

The lipid flippase MoNeo1 mediates vesicle trafficking and pathogenicity in Magnaporthe oryzae. [PDF]

Stress Biol
Cai Y, Huang X, Nie Y, Luan Y, Aarti A, Gong Q, Sun P, Abubakar YS, Wang B, Wang A, Li G, Lin L, Zheng W.   +12 more
europepmc   +1 more source