Results 191 to 200 of about 152,465 (288)

Reprogramming Antitumor Immunity: NK Cell Strategies to Navigate the Immunosuppressive Tumor Microenvironment

Advanced Science, EarlyView.
ABSTRACT Tumor immune escape is a major barrier to durable cancer immunotherapy, as advanced malignancies create a tumor microenvironment (TME) that preferentially exhausts and disables T cell responses. While most approved cell therapies are T cell‐based, this limitation motivates the exploration of an alternative effector cell platform.
Tereza Kochs, Pranay Nath, Alice Chen, Rizwan Romee, Andreia Maia   +4 more
wiley   +1 more source

Targeting myoferlin in ER/Golgi vesicle trafficking reprograms pancreatic cancer-associated fibroblasts. [PDF]

EMBO J
Peiffer R, Laverdeur E, Gaigneaux A, Boumahd Y, Gullo C, Rademaker G, Crake R, Lavergne A, Maloujahmoum N, Agirman F, Herfs M, Masamune A, Letellier E, Bellahcène A, Peulen O.   +14 more
europepmc   +1 more source

ELMOD3-Rab1A-Flotillin2 cascade regulates lumen formation via vesicle trafficking in Ciona notochord. [PDF]

Open Biol, 2023
Liu A, Ouyang X, Wang Z, Dong B.
europepmc   +1 more source

A Biomimetic Nanoparticle System Intercepts and Degrades Thrombospondin‐1 to Restore Vascular Homeostasis After Ischemic Injury

Advanced Science, EarlyView.
TAX2‐NPs capture extracellular TSP‐1 in the injured liver and promote its macrophage‐mediated autophagic degradation. This process blocks TSP‐1/CD47 signaling, restores VEGFR2‐AKT activity, preserves endothelial function, and mitigates hepatic ischemia‐reperfusion injury.
Haorui Wang, Xiandi Meng, Yanbao Xin, Kuirong Mao, Huizhu Tan, Changkai Ma, Xiuxiu Cong, Mengfei Zhao, Meiling Yu, Si Chen, Yue Hou, Yong‐Guang Yang, Tianmeng Sun   +12 more
wiley   +1 more source

Correction: The role of vesicle trafficking genes in osteoblast differentiation and function. [PDF]

Sci Rep
Zhu H, Su Y, Wang J, Wu JY.
europepmc   +1 more source

Synergism of vesicle trafficking and cytoskeleton during regulation of plant growth and development: A mechanistic outlook.

Heliyon, 2023
Khoso MA, Zhang H, Khoso MH, Poudel TR, Wagan S, Papiashvili T, Saha S, Ali A, Murtaza G, Manghwar H, Liu F.   +10 more
europepmc   +1 more source

Point mutations in the catalytic domain disrupt cellulose synthase (CESA6) vesicle trafficking and protein dynamics. [PDF]

Plant Cell, 2023
Huang L, Zhang W, Li X, Staiger CJ, Zhang C.   +4 more
europepmc   +1 more source

Scalable Engineering of Bio‐Manufactured Extracellular Vesicles for Selective Delivery in Ovarian Cancer Patient‐Derived Models

Advanced Science, EarlyView.
Engineered extracellular vesicles displaying Ephrin‐B2 selectively target Ephrin‐B4–expressing ovarian cancer cells, enabling precise delivery in patient‐derived models. This scalable bio‐manufacturing platform reveals a versatile strategy to exploit Ephrin signaling for highly specific therapeutic payload delivery and motivates exploration of tailored
Nihar Godbole, Andrew Lai, Alexander Quinn, Marianne Gillard, Dominic Guanzon, Katherin Scholz‐Romero, Alexis Salas‐Burgos, Bastián Lillo Dapremont, Rohan Lourie, Naven Chetty, Richard Lobb, Kate Beecher, Amy E. McCart Reed, Kaltin Ferguson, Biao Sun, Yaowu He, John D. Hooper, Carlos Salomon   +17 more
wiley   +1 more source

Quantum Dots for Biomedical Biosensing, NIR‐II Bioimaging, and Phototherapy: Materials Design, Signal Transduction, and Translational Barriers

Advanced Science, EarlyView.
This review outlines bottom‐up and biomimetic fabrication strategies of quantum dots, and highlights their emerging applications in biosensing, multimodal bioimaging, and intelligent cancer theranostics. It further discusses key translational barriers and future perspectives for advancing QD‐based nanomedicine toward clinical implementation.
Jie Ju, Zhifang Liu, Xinran Gao, Wen Sun, Wei Fu, Yanfei Wang   +5 more
wiley   +1 more source

Proteomic profiling reveals dynamic regulation of vesicle trafficking across glioma grades. [PDF]

J Neurooncol
Pienkowski T, Mojsak P, Kowalczyk T, Cysewski D, Krupa M, Rutkowski R, Mariak Z, Godlewski A, Reszec J, Moniuszko M, Kretowski A, Lyson T, Ciborowski M.   +12 more
europepmc   +1 more source