Results 91 to 100 of about 61,850 (209)

Cell-specific targeting of lentiviral vectors mediated by fusion proteins derived from Sindbis virus, vesicular stomatitis virus, or avian sarcoma/leukosis virus

Retrovirology, 2010
Background The ability to efficiently and selectively target gene delivery vectors to specific cell types in vitro and in vivo remains one of the formidable challenges in gene therapy.
Marino Michael P, Bialkowska Agnieszka, Kutner Robert H, Zhang Xian-Yang, Klimstra William B, Reiser Jakob   +5 more
doaj   +1 more source

Structure of the Vesicular Stomatitis Virus L Protein in Complex with Its Phosphoprotein Cofactor

Cell Reports, 2020
Summary: The large (L) proteins of non-segmented, negative-strand RNA viruses are multifunctional enzymes that produce capped, methylated, and polyadenylated mRNA and replicate the viral genome.
Simon Jenni, Louis-Marie Bloyet, Ruben Diaz-Avalos, Bo Liang, Sean P.J. Whelan, Nikolaus Grigorieff, Stephen C. Harrison   +6 more
doaj   +1 more source

Highly Efficient Gene Expression in B Lymphocytes Mediating by Lentivirus Vector [PDF]

, 2012
Gene transduction and expression efficiencies among several type cell lines were compared by using vesicular stomatitis virus-glycoprotein (VSV-G) pseudotyped human immunodeficiency virus type-1 (HIV-1) based lentivirus vector. Large discrepancies of the
Akira Tempaku
core   +1 more source

Rhabdovirus-based vaccine platforms against henipaviruses. [PDF]

, 2014
UNLABELLED: The emerging zoonotic pathogens Hendra virus (HeV) and Nipah virus (NiV) are in the genus Henipavirus in the family Paramyxoviridae. HeV and NiV infections can be highly fatal to humans and livestock.
Feldmann, Heinz, Kurup, Drishya, Marzi, Andrea, Schnell, Matthias J, Wirblich, Christoph   +4 more
core   +2 more sources

Structural basis for the recognition of LDL-receptor family members by VSV glycoprotein

Nature Communications, 2018
Glycoprotein G of vesicular stomatitis virus (VSV) enables viral entry by binding to the major VSV receptor LDL-R. Here the authors present crystal structures of G in complex with two distinct CR domains of LDL-R, identifying structural determinants for ...
Jovan Nikolic, Laura Belot, Hélène Raux, Pierre Legrand, Yves Gaudin, Aurélie A. Albertini   +5 more
doaj   +1 more source

Viral Evolution and Adaptation as a Multivariate Branching Process

, 2013
In the present work we analyze the problem of adaptation and evolution of RNA virus populations, by defining the basic stochastic model as a multivariate branching process in close relation with the branching process advanced by Demetrius, Schuster and ...
Antoneli, Fernando, Bosco, Francisco, Castro, Diogo, Janini, Luiz Mário Ramos, Mondaini, R. P.   +4 more
core   +1 more source

Neurotropism of Vesicular Stomatitis Virus

Experimental Biology and Medicine, 1933
The virus of vesicular stomatitis is peculiarly epitheliotropic (der-motropic) in the guinea pig: only the pad tissue of the dermal surface is uniformly susceptible.1, 2, 3Through the kindness of Dr. W. E. Cotton, samples were sent us of Indiana and New Jersey strains of virus propagated in guinea pig pads for several years.
H. R. Cox, P. K. Olitsky
openaire   +1 more source

Interrogating Genomes and Geography to Unravel Multiyear Vesicular Stomatitis Epizootics

Viruses
We conducted an integrative analysis to elucidate the spatial epidemiological patterns of the Vesicular Stomatitis New Jersey virus (VSNJV) during the 2014–15 epizootic cycle in the United States (US).
John M. Humphreys, Phillip T. Shults, Lauro Velazquez-Salinas, Miranda R. Bertram, Angela M. Pelzel-McCluskey, Steven J. Pauszek, Debra P. C. Peters, Luis L. Rodriguez   +7 more
doaj   +1 more source

Pseudotyping exosomes for enhanced protein delivery in mammalian cells. [PDF]

, 2017
Exosomes are cell-derived nanovesicles that hold promise as living vehicles for intracellular delivery of therapeutics to mammalian cells. This potential, however, is undermined by the lack of effective methods to load exosomes with therapeutic proteins ...
Li, Lingxuan, Losacco, Joseph, Lu, Biao, Marriott, Gerard, Meyer, Conary, Stickney, Zachary   +5 more
core  

Vesicular stomatitis virus enables gene transfer and transsynaptic tracing in a wide range of organisms [PDF]

, 2015
Current limitations in technology have prevented an extensive analysis of the connections among neurons, particularly within nonmammalian organisms. We developed a transsynaptic viral tracer originally for use in mice, and then tested its utility in a ...
Baskerville A, Bussereau F, Cajal SR, Fujii H, Garm A, Güntürkün O, Huang L, Johnson KM, Knipe DM, Long GR, Maaswinkel H, Mead DG, Metcalfe WK, Mey J, Nichol ST, Pol AN, Sebesteny T, Tesh R, Wickersham IR, Wyers F, Yasumura Y, Ye Z   +21 more
core   +2 more sources