Results 11 to 20 of about 43,587 (194)

CONSTRUCTION AND STUDY OF Althaea officinalis TRANSGENIC ROOTS CULTURE WITH HUMAN INTERFERON α2B GENE [PDF]

open access: yesBiotechnologia Acta, 2013
The aim of our work was to obtain Althaea officinalis L. «hairy» root culture with human interferon α2b gene (ifn-α2b), to measure fructans content and antiviral activity of extracts from the transgenic roots. Transformation of leaf and root explants was
N. A. Matvieieva   +4 more
doaj   +1 more source

Polarimetric imaging for the detection of synthetic models of SARS-CoV-2: a proof of concept [PDF]

open access: yes, 2022
Objective: To conduct a proof-of-concept study of the detection of two synthetic models of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) using polarimetric imaging. Methods: Two SARS-CoV-2 models were prepared as engineered lentiviruses pseudotyped with the G protein of the vesicular stomatitis virus, and with the characteristic Spike ...
arxiv   +1 more source

Patch formation driven by stochastic effects of interaction between viruses and defective interfering particles [PDF]

open access: yesPLoS Comput Biol 19(10), 2023, 2023
Defective interfering particles (DIPs) are virus-like particles that occur naturally during virus infections. These particles are defective, lacking essential genetic materials for replication, but they can interact with the wild-type virus and potentially be used as therapeutic agents.
arxiv   +1 more source

A VSV-based assay quantifies coronavirus Mpro/3CLpro/Nsp5 main protease activity and chemical inhibition

open access: yesCommunications Biology, 2022
A vesicular stomatitis virus (VSV)-based assay enables high-throughput screening for small molecular protease inhibitors that can block viral proteases, like the Mpro/3CLpro/Nsp5 in SARS-CoV-2.
Emmanuel Heilmann   +7 more
doaj   +1 more source

Aptamer-facilitated Protection of Oncolytic Virus from Neutralizing Antibodies

open access: yesMolecular Therapy: Nucleic Acids, 2014
Oncolytic viruses promise to significantly improve current cancer treatments through their tumor-selective replication and multimodal attack against cancer cells.
Darija Muharemagic   +6 more
doaj   +1 more source

Examination of vesicular stomatitis virus-induced morphology changes in individual Vero cells by QMod microscopy

open access: yesBioTechniques, 2020
Viral infection of cultured cells induces changes in the biophysical characteristics of the affected cells. Advanced microscopic cameras such as Ovizio’s QMod, coupled with the appropriate software, can measure a variety of characteristics on a per-cell ...
Isabel Scholz   +2 more
doaj   +1 more source

Viroses confundíveis com febre aftosa Viral diseases to be differentiated from foot-and-mouth disease

open access: yesCiência Rural, 1996
Revisam-se as doenças que devem ser consideradas no diagnóstico diferencial de febre aftosa. Dentre as doenças vesiculares ou erosivas, descrevem-se os principais aspectos relacionados ao diagnóstico da estomatite vesicular, diarréia viral bovina, febre ...
Franklin Riet-Correa   +3 more
doaj   +1 more source

A method for the generation of pseudovirus particles bearing SARS coronavirus spike protein in high yields

open access: yesCell Structure and Function, 2022
The ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has threatened human health and the global economy. Development of additional vaccines and therapeutics is urgently required, but such development with live virus must be ...
Yoichiro Fujioka   +7 more
doaj   +1 more source

Fitness Determinations in Vesicular Stomatitis Virus

open access: yesBio-Protocol, 2014
Fitness is defined as the overall replicative ability. Testing whether a mutation (or combination of mutations) has an effect on fitness often relays on determining virus production as a surrogate measurement. However, viruses do not usually replicate in
Isabel Novella
doaj   +1 more source

Bat Employs a Conserved MDA5 Gene to Trigger Antiviral Innate Immune Responses

open access: yesFrontiers in Immunology, 2022
Bats are important hosts for various zoonotic viral diseases. However, they rarely show signs of disease infection with such viruses. As the first line for virus control, the innate immune system of bats attracted our full attention.
Jie Wang   +9 more
doaj   +1 more source

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