Results 51 to 60 of about 60,004 (165)
Type I interferon signalling and interferon‐responsive microglia in health and disease
The FEBS Journal, EarlyView.Recent insights reveal that type I interferon (IFN‐I) signalling plays critical roles in the nervous system beyond antiviral defence. Dysregulated IFN‐I activity is increasingly linked to neurological dysfunction and neurodegeneration, with microglia as central mediators. This review explores the broader impact of IFN‐I signalling on the nervous system
Jose P. Lopez‐Atalaya +1 more
wiley +1 more source
Protein Kinase and Phosphoproteins of Vesicular Stomatitis Virus [PDF]
Journal of Virology, 1974 Protein kinases of similar but not identical activity were found associated with vesicular stomatitis (VS) virions grown in mouse L cells, primary chicken embryo (CE) cells, and BHK-21 cells, as well as being present in VS virions grown in HeLa and Aedes albopictus cells.
Richard L. Imblum, Robert R. Wagner
openaire +3 more sources
The Current State of Clinical Diagnostic Algorithms for Mucosal Oral Lesions: A Scoping Review
Oral Diseases, EarlyView.ABSTRACT Background Diagnosing oral lesions remains challenging for many dentists. Despite the availability of diagnostic algorithms, there is a dearth of comprehensive evidence synthesis and a discussion on their clinical and pedagogical applicability.
Mohammed Al‐Shehri +7 more
wiley +1 more source
The impact of hypoxia on oncolytic virotherapy [PDF]
, 2011 The hypoxic tumor microenvironment plays significant roles in tumor cell metabolism and survival, tumor growth, and progression. Hypoxia modulates target genes in target cells mainly through an oxygen-sensing signaling pathway mediated by hypoxia ...
Sheng Guo, Z
core +3 more sources
Recent optical approaches for anatomical and functional dissection of neuron–astrocyte circuitry
The Journal of Physiology, EarlyView.Abstract figure legend This review summarises novel optical approaches to deciphering structural and functional wiring diagrams of neuron–astrocyte circuits in the brain. There are three groups: the anatomical proximity assay, transsynaptic viral tracing and the functional connection assay. The FRET‐based neuron–astrocyte proximity assay allows mapping
Yoshiki Hatashita, Takafumi Inoue
wiley +1 more source
Inhibition of VSV Genome RNA Replication but Not Transcription by Monoclonal Antibodies Specific for the Viral P Protein [PDF]
, 1996 The growth of vesicular stomatitis virus requires two distinct RNA synthetic events: transcription of messenger RNA molecules and replication of the viral genome RNA.
PELUSO, RICHARD W., RICHARDSON, JAMES C.
core +1 more source
Engineering CAR‐T Therapeutics for Enhanced Solid Tumor Targeting
Advanced Materials, Volume 37, Issue 23, June 12, 2025.CART cell therapy has proven effective for blood cancers but struggles with solid tumors due to diverse antigens and complex environments. Recent efforts focus on improving CAR design and validation platforms. Advances in protein engineering, machine learning, and organoid systems aim to enhance CAR‐T therapy against solid tumors.
Danqing Zhu +4 more
wiley +1 more source
Polyadenylation of Vesicular Stomatitis Virus mRNA [PDF]
Journal of Virology, 1974 Vesicular stomatitis virus (VSV) mRNA isolated from infected cell polysomes contains polyadenylic acid [poly(A)] sequences. Detergent-activated purified virions in vitro can transcribe complementary RNA, which has sedimentation properties similar to mRNA, and this RNA also contains poly(A) sequences.
openaire +3 more sources
Small, Volume 21, Issue 23, June 12, 2025.This study introduces an all‐in‐one diagnostic system that amplifies target genes through interactions between serum EVs and fusogenic liposomes. Using padlock probes and enzymes within liposomes, the system enables miRNA amplification upon fusion. It successfully detects miR‐33a, miR‐126, and miR‐145, showing strong diagnostic performance comparable ...
Jiyoon Lee +14 more
wiley +1 more source
Inactivation of Vesicular Stomatitis Virus by Disinfectants
Applied Microbiology, 1970 Twenty-four chemical disinfectants considered to be viricidal were tested. Ten disinfectants were not viricidal for vesicular stomatitis virus within 10 min at 20 C when an LD 50 titer of 10 8.5 virus units per 0.1 ml were to be inactivated.
openaire +3 more sources