Results 1 to 10 of about 9,435 (255)

Vigabatrin inhibits seizures and mTOR pathway activation in a mouse model of tuberous sclerosis complex. [PDF]

PLoS ONE, 2013
Epilepsy is a common neurological disorder and cause of significant morbidity and mortality. Although antiseizure medication is the first-line treatment for epilepsy, currently available medications are ineffective in a significant percentage of patients
Bo Zhang, Sharon S McDaniel, Nicholas R Rensing, Michael Wong   +3 more
doaj   +2 more sources

Mean global field power is reduced in infantile epileptic spasms syndrome after response to vigabatrin [PDF]

Frontiers in Neurology
PurposeInfantile epileptic spasms syndrome (IESS) is associated with abnormal neuronal networks during a critical period of synaptogenesis and brain plasticity. Hypsarrhythmia is a visual EEG biomarker used to diagnose IESS, assess response to treatment,
Arjun Nair, Joycelyne Ewusie, Rowan Pentz, Robyn Whitney, Kevin Jones   +4 more
doaj   +2 more sources

Epileptic spasms relapse is associated with response latency but not conventional attributes of post‐treatment EEG [PDF]

Epilepsia Open
Objective Relapse of epileptic spasms after initial treatment of infantile epileptic spasms syndrome (IESS) is common. However, past studies of small cohorts have inconsistently linked relapse risk to etiology, treatment modality, and EEG features upon ...
Emmi Deckard, Rujuta Sathe, David Tabibzadeh, Aria Terango, Aran Groves, Rajsekar R. Rajaraman, Hiroki Nariai, Shaun A. Hussain   +7 more
doaj   +2 more sources

GRIN1‐related epilepsy in a neonate with response to memantine and vigabatrin

Annals of the Child Neurology Society
Objective A newborn with GRIN1‐related early infantile developmental and epileptic encephalopathy (DEE) with striking pharmacoresistance is described with emphasis on potential therapy with memantine and vigabatrin.
Isabella Eiler, Hope M. Reecher, Katherine Carlton, Erwin Cabacungan, Susan Cohen, Samuel Adams, Jenna Jozwik, Avantika Singh   +7 more
doaj   +2 more sources

Short Course and Early Switch of Vigabatrin for Infantile spasms [PDF]

Annals of Child Neurology, 2020
Purpose Vigabatrin has proven efficacy in the treatment of infantile spasms, but it carries the risk of irreversible visual field constriction. The incidence of vigabatrin-induced visual field constriction seems to depend on the extent of vigabatrin ...
Hye Won Ryu, Hunmin Kim, Byung Chan Lim, Hee Hwang, Jong-Hee Chae, Ji Eun Choi, Ki Joong Kim   +6 more
doaj   +1 more source

Early Treatment with Vigabatrin Does Not Decrease Focal Seizures or Improve Cognition in Tuberous Sclerosis Complex: The PREVeNT Trial

Annals of Neurology, 2023
This study was undertaken to test the hypothesis that early vigabatrin treatment in tuberous sclerosis complex (TSC) infants improves neurocognitive outcome at 24 months of age.
E. Bebin, Jurriaan M. Peters, Brenda E. Porter, Tarrant O. McPherson, S. O’Kelley, M. Sahin, Katherine S. Taub, R. Rajaraman, Stephanie C. Randle, William M. McClintock, Mary Kay Koenig, Mike D. Frost, H. Northrup, Klaus Werner, Danielle A. Nolan, M. Wong, Jessica Krefting, F. Biasini, Kalyani Peri, G. Cutter, D. Krueger   +20 more
semanticscholar   +1 more source

EVALUATION OF THE STABILITY OF VIGABATRIN IN HOSPITALAR EXTEMPORANEOUS FORMULATIONS

Drug Analytical Research, 2019
The aim of this study was to analyze the chemical stability of the anticonvulsant vigabatrin extemporaneous formulation from tablets in storage conditions of different temperatures and types of packaging used.
Marcio Vinicius Ayres, Sarah Chagas Campanharo, Elfrides Schapoval, Nathalie Ribeiro Wingert, Martin Steppe   +4 more
doaj   +9 more sources

Vigabatrin-associated Reversible MRI Abnormalities in an Infant with Tuberous Sclerosis.

Journal of Radiology Case Reports, 2021
Vigabatrin therapy is commonly used in infants diagnosed with tuberous sclerosis complex, particularly in the setting of epilepsy. Utilization of vigabatrin can result in bilateral and symmetric abnormal sequence changes within the deep brain matter and ...
Joseph Franklin Craft, A. Cardenas
semanticscholar   +1 more source

Anticipatory banking of samples enables diagnosis of adenylosuccinase deficiency following molecular autopsy in an infant with vacuolating leukoencephalopathy

American Journal of Medical Genetics Part A, Volume 191, Issue 1, Page 234-237, January 2023., 2023
Abstract Adenylosuccinase deficiency is a rare inborn error of metabolism. We present a newborn who died at 52 days of age with clinical features suggestive of severe epileptic encephalopathy and leukodystrophy of unknown cause. Post‐mortem examination showed an unusual vacuolar appearance of the brain.
Spatikha Sitaram, Hetalika C. Banka, Grace Vassallo, Julija Pavaine, Adele Fairclough, Ronnie Wright, Lynette Fairbanks, Jörgen Bierau, Lydia Bowden, Bernd Schwahn, Alistair Horman, Siddharth Banka   +11 more
wiley   +1 more source

Peripheral visual field defect of vigabatrin in pediatric epilepsy: A review

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, 2023
Vigabatrin is the medication used for the treatment of infantile spasms and refractory complex partial seizures, but its usage has always been contradictory due to its effect on vision.
Umme Habeeba A. Pathan, Navapreetha Shetty, Safiya Anhar, Reshma Mayya   +3 more
doaj   +1 more source