Clinical profile of vigabatrin as monotherapy for treatment of infantile spasms [PDF]
Neuropsychiatric Disease and Treatment, 2010 Jason T Lerner1, Noriko Salamon2, Raman Sankar1,31Departments of Pediatrics, 2Radiological Sciences, 3Neurology, David Geffen School of Medicine, University of California Los Angeles and Mattel Children’s Hospital at UCLA, Los Angeles, CA ...
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Mean global field power is reduced in infantile epileptic spasms syndrome after response to vigabatrin [PDF]
Frontiers in NeurologyPurposeInfantile epileptic spasms syndrome (IESS) is associated with abnormal neuronal networks during a critical period of synaptogenesis and brain plasticity. Hypsarrhythmia is a visual EEG biomarker used to diagnose IESS, assess response to treatment,
Arjun Nair +4 more
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Clinical profile and treatment of infantile spasms using vigabatrin and ACTH - a developing country perspective [PDF]
BMC Pediatrics, 2010 Background Infantile spasms represent a serious epileptic syndrome that occurs in the early infantile age. ACTH and Vigabatrin are actively investigated drugs in its treatment.
Ishaque Sidra +3 more
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Epilepsia, 1999 Summary:Vigabatrin (VGB) is a structural analogue of the inhibitory neurotransmitter γ‐amino butyric acid (GABA), which produces its antiepileptic effect by irreversibly inhibiting the degradative enzyme GABA‐transaminase. This produces an increase in central nervous system (CNS) GABA levels.
Jacqueline A. French
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Vigabatrin-Induced Visual Field Defects [PDF]
Pediatric Neurology Briefs, 1998 A drug surveillance database at Hoechst Marion Roussel, manufacturers of vigabatrin, identified 92 cases of symptomatic visual field defects associated with vigabatrin (usually as add-on therapy) between 1990 and 1997.
J Gordon Millichap
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Microstructural injury to the optic nerve with vigabatrin treatment in West syndrome: A DTI study [PDF]
Scientific ReportsTo evaluate optic nerve injury associated with vigabatrin treatment in children with West syndrome using diffusion tensor imaging. Thirty-five children with West syndrome (aged 9 days–22 months) were retrospectively analyzed and grouped as follows: (1 ...
Junjie Hu +7 more
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Dissolution and stability of vigabatrin powder in water, fruit juice, milk, and infant formula [PDF]
Epilepsy & Behavior ReportsThe prescribing information for the antiseizure medication Vigadrone® (vigabatrin) Powder for Oral Solution advises only reconstituting the powder in water prior to administration and discarding unused solution.
Michelle Zachman +3 more
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Combination Therapy With Vigabatrin and Prednisolone Versus Vigabatrin Alone for Infantile Spasms [PDF]
Annals of Clinical and Translational NeurologyObjective The study evaluated the effectiveness of combination therapy with vigabatrin and prednisolone versus vigabatrin alone for treating infantile epileptic spasms syndrome (IESS).
Rachata Boonkrongsak +6 more
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The role of antioxidant and anti-inflammatory mechanisms in the protective effects of vigabatrin against ovarian ischemia-reperfusion injury in a rat model [PDF]
Journal of Ovarian ResearchBackground Exposure of ovarian tissue to ischaemia and subsequent reperfusion can result in oxidative and inflammatory damage. A decline in adenosine triphosphate (ATP) levels has the potential to initiate pathological processes and compromise ...
Elif Hizal +8 more
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Symptomatic vigabatrin‐associated MRI toxicity is associated with simultaneous hormonal therapy among patients with infantile spasms [PDF]
Epilepsia OpenVigabatrin‐associated brain abnormalities on MRI (VABAM) are observed in approximately 20% of children who receive vigabatrin for treatment of infantile epileptic spasms syndrome.
Rujuta Sathe +6 more
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