Results 1 to 10 of about 15,083 (304)

Combination Therapy With Vigabatrin and Prednisolone Versus Vigabatrin Alone for Infantile Spasms [PDF]

Annals of Clinical and Translational Neurology
Objective The study evaluated the effectiveness of combination therapy with vigabatrin and prednisolone versus vigabatrin alone for treating infantile epileptic spasms syndrome (IESS).
Rachata Boonkrongsak, Kantapon Trongkamolchai, Sirorat Suwannachote, Somjit Sri‐Udomkajorn, Raviwan Wittawassamrankul, Ravindra Arya, Kullasate Sakpichaisakul   +6 more
doaj   +4 more sources

Microstructural injury to the optic nerve with vigabatrin treatment in West syndrome: A DTI study [PDF]

Scientific Reports
To evaluate optic nerve injury associated with vigabatrin treatment in children with West syndrome using diffusion tensor imaging. Thirty-five children with West syndrome (aged 9 days–22 months) were retrospectively analyzed and grouped as follows: (1 ...
Junjie Hu, Li Chen, Gongwei Zhang, Yu Fang, Huiting Zhang, Yilian Li, Jianxiang Liao, Cailei Zhao   +7 more
doaj   +2 more sources

Clinical profile and treatment of infantile spasms using vigabatrin and ACTH - a developing country perspective [PDF]

BMC Pediatrics, 2010
Background Infantile spasms represent a serious epileptic syndrome that occurs in the early infantile age. ACTH and Vigabatrin are actively investigated drugs in its treatment.
Ishaque Sidra, Gulab Shamshad, Ibrahim Shahnaz, Saleem Taimur   +3 more
doaj   +5 more sources

Symptomatic vigabatrin‐associated MRI toxicity is associated with simultaneous hormonal therapy among patients with infantile spasms [PDF]

Epilepsia Open
Vigabatrin‐associated brain abnormalities on MRI (VABAM) are observed in approximately 20% of children who receive vigabatrin for treatment of infantile epileptic spasms syndrome.
Rujuta Sathe, Gyaneshwar Shrestha, Aria Terango, David Tabibzadeh, Rajsekar R. Rajaraman, Hiroki Nariai, Shaun A. Hussain   +6 more
doaj   +2 more sources

Dissolution and stability of vigabatrin powder in water, fruit juice, milk, and infant formula [PDF]

Epilepsy & Behavior Reports
The prescribing information for the antiseizure medication Vigadrone® (vigabatrin) Powder for Oral Solution advises only reconstituting the powder in water prior to administration and discarding unused solution.
Michelle Zachman, Lixin Gong, Lingling An, Mark B. Halvorsen   +3 more
doaj   +2 more sources

Vigabatrin inhibits seizures and mTOR pathway activation in a mouse model of tuberous sclerosis complex. [PDF]

PLoS ONE, 2013
Epilepsy is a common neurological disorder and cause of significant morbidity and mortality. Although antiseizure medication is the first-line treatment for epilepsy, currently available medications are ineffective in a significant percentage of patients
Bo Zhang, Sharon S McDaniel, Nicholas R Rensing, Michael Wong   +3 more
doaj   +2 more sources

Treatment efficacy for infantile epileptic spasms syndrome in children with trisomy 21 [PDF]

Frontiers in Pediatrics
BackgroundInfantile Epileptic Spasms Syndrome (IESS) is the most common epilepsy syndrome in children with trisomy 21. First-line standard treatments for IESS include adrenocorticotropic hormone (ACTH), oral corticosteroids, and vigabatrin.
Henry Chen, Henry Chen, Adam L. Numis, Adam L. Numis, Renée A. Shellhaas, John R. Mytinger, Debopam Samanta, Rani K. Singh, Rani K. Singh, Shaun A. Hussain, Danielle Takacs, Kelly G. Knupp, Li-Rong Shao, Carl E. Stafstrom   +13 more
doaj   +2 more sources

Mean global field power is reduced in infantile epileptic spasms syndrome after response to vigabatrin [PDF]

Frontiers in Neurology
PurposeInfantile epileptic spasms syndrome (IESS) is associated with abnormal neuronal networks during a critical period of synaptogenesis and brain plasticity. Hypsarrhythmia is a visual EEG biomarker used to diagnose IESS, assess response to treatment,
Arjun Nair, Joycelyne Ewusie, Rowan Pentz, Robyn Whitney, Kevin Jones   +4 more
doaj   +2 more sources

Clinical profile of vigabatrin as monotherapy for treatment of infantile spasms [PDF]

Neuropsychiatric Disease and Treatment, 2010
Jason T Lerner1, Noriko Salamon2, Raman Sankar1,31Departments of Pediatrics, 2Radiological Sciences, 3Neurology, David Geffen School of Medicine, University of California Los Angeles and Mattel Children’s Hospital at UCLA, Los Angeles, CA ...
Jason T Lerner, Noriko Salamon, Raman Sankar   +2 more
doaj   +5 more sources

Vigabatrin for Infantile Spasms

Pediatric Neurology Briefs, 1999
The efficacy of vigabatrin (VGB) as the first, and adrenocorticotropin hormone (ACTH) or valproate (VPA) as the second, treatment of choice for newly diagnosed infantile spasms was evaluated in 42 infants treated at the University of Helsinki, Finland.
J Gordon Millichap
doaj   +3 more sources