Microstructural injury to the optic nerve with vigabatrin treatment in West syndrome: A DTI study [PDF]
Scientific ReportsTo evaluate optic nerve injury associated with vigabatrin treatment in children with West syndrome using diffusion tensor imaging. Thirty-five children with West syndrome (aged 9 days–22 months) were retrospectively analyzed and grouped as follows: (1 ...
Junjie Hu +7 more
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Clinical profile and treatment of infantile spasms using vigabatrin and ACTH - a developing country perspective [PDF]
BMC Pediatrics, 2010 Background Infantile spasms represent a serious epileptic syndrome that occurs in the early infantile age. ACTH and Vigabatrin are actively investigated drugs in its treatment.
Ishaque Sidra +3 more
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Combination Therapy With Vigabatrin and Prednisolone Versus Vigabatrin Alone for Infantile Spasms [PDF]
Annals of Clinical and Translational NeurologyObjective The study evaluated the effectiveness of combination therapy with vigabatrin and prednisolone versus vigabatrin alone for treating infantile epileptic spasms syndrome (IESS).
Rachata Boonkrongsak +6 more
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Dissolution and stability of vigabatrin powder in water, fruit juice, milk, and infant formula [PDF]
Epilepsy & Behavior ReportsThe prescribing information for the antiseizure medication Vigadrone® (vigabatrin) Powder for Oral Solution advises only reconstituting the powder in water prior to administration and discarding unused solution.
Michelle Zachman +3 more
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Symptomatic vigabatrin‐associated MRI toxicity is associated with simultaneous hormonal therapy among patients with infantile spasms [PDF]
Epilepsia OpenVigabatrin‐associated brain abnormalities on MRI (VABAM) are observed in approximately 20% of children who receive vigabatrin for treatment of infantile epileptic spasms syndrome.
Rujuta Sathe +6 more
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The role of antioxidant and anti-inflammatory mechanisms in the protective effects of vigabatrin against ovarian ischemia-reperfusion injury in a rat model [PDF]
Journal of Ovarian ResearchBackground Exposure of ovarian tissue to ischaemia and subsequent reperfusion can result in oxidative and inflammatory damage. A decline in adenosine triphosphate (ATP) levels has the potential to initiate pathological processes and compromise ...
Elif Hizal +8 more
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Treatment efficacy for infantile epileptic spasms syndrome in children with trisomy 21 [PDF]
Frontiers in PediatricsBackgroundInfantile Epileptic Spasms Syndrome (IESS) is the most common epilepsy syndrome in children with trisomy 21. First-line standard treatments for IESS include adrenocorticotropic hormone (ACTH), oral corticosteroids, and vigabatrin.
Henry Chen +13 more
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Clinical profile of vigabatrin as monotherapy for treatment of infantile spasms [PDF]
Neuropsychiatric Disease and Treatment, 2010 Jason T Lerner1, Noriko Salamon2, Raman Sankar1,31Departments of Pediatrics, 2Radiological Sciences, 3Neurology, David Geffen School of Medicine, University of California Los Angeles and Mattel Children’s Hospital at UCLA, Los Angeles, CA ...
Jason T Lerner +2 more
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Mean global field power is reduced in infantile epileptic spasms syndrome after response to vigabatrin [PDF]
Frontiers in NeurologyPurposeInfantile epileptic spasms syndrome (IESS) is associated with abnormal neuronal networks during a critical period of synaptogenesis and brain plasticity. Hypsarrhythmia is a visual EEG biomarker used to diagnose IESS, assess response to treatment,
Arjun Nair +4 more
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Short Course and Early Switch of Vigabatrin for Infantile spasms [PDF]
Annals of Child Neurology, 2020 Purpose Vigabatrin has proven efficacy in the treatment of infantile spasms, but it carries the risk of irreversible visual field constriction. The incidence of vigabatrin-induced visual field constriction seems to depend on the extent of vigabatrin ...
Hye Won Ryu +6 more
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