Microstructural injury to the optic nerve with vigabatrin treatment in West syndrome: A DTI study [PDF]
Scientific ReportsTo evaluate optic nerve injury associated with vigabatrin treatment in children with West syndrome using diffusion tensor imaging. Thirty-five children with West syndrome (aged 9 days–22 months) were retrospectively analyzed and grouped as follows: (1 ...
Junjie Hu +7 more
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Clinical profile and treatment of infantile spasms using vigabatrin and ACTH - a developing country perspective [PDF]
BMC Pediatrics, 2010 Background Infantile spasms represent a serious epileptic syndrome that occurs in the early infantile age. ACTH and Vigabatrin are actively investigated drugs in its treatment.
Ishaque Sidra +3 more
doaj +5 more sources
Combination Therapy With Vigabatrin and Prednisolone Versus Vigabatrin Alone for Infantile Spasms [PDF]
Annals of Clinical and Translational NeurologyObjective The study evaluated the effectiveness of combination therapy with vigabatrin and prednisolone versus vigabatrin alone for treating infantile epileptic spasms syndrome (IESS).
Rachata Boonkrongsak +6 more
doaj +2 more sources
Dissolution and stability of vigabatrin powder in water, fruit juice, milk, and infant formula [PDF]
Epilepsy & Behavior ReportsThe prescribing information for the antiseizure medication Vigadrone® (vigabatrin) Powder for Oral Solution advises only reconstituting the powder in water prior to administration and discarding unused solution.
Michelle Zachman +3 more
doaj +2 more sources
Symptomatic vigabatrin‐associated MRI toxicity is associated with simultaneous hormonal therapy among patients with infantile spasms [PDF]
Epilepsia OpenVigabatrin‐associated brain abnormalities on MRI (VABAM) are observed in approximately 20% of children who receive vigabatrin for treatment of infantile epileptic spasms syndrome.
Rujuta Sathe +6 more
doaj +2 more sources
The role of antioxidant and anti-inflammatory mechanisms in the protective effects of vigabatrin against ovarian ischemia-reperfusion injury in a rat model [PDF]
Journal of Ovarian ResearchBackground Exposure of ovarian tissue to ischaemia and subsequent reperfusion can result in oxidative and inflammatory damage. A decline in adenosine triphosphate (ATP) levels has the potential to initiate pathological processes and compromise ...
Elif Hizal +8 more
doaj +2 more sources
EVALUATION OF THE STABILITY OF VIGABATRIN IN HOSPITALAR EXTEMPORANEOUS FORMULATIONS
Drug Analytical Research, 2019 The aim of this study was to analyze the chemical stability of the anticonvulsant vigabatrin extemporaneous formulation from tablets in storage conditions of different temperatures and types of packaging used.
Marcio Vinicius Ayres +4 more
doaj +11 more sources
Treatment efficacy for infantile epileptic spasms syndrome in children with trisomy 21 [PDF]
Frontiers in PediatricsBackgroundInfantile Epileptic Spasms Syndrome (IESS) is the most common epilepsy syndrome in children with trisomy 21. First-line standard treatments for IESS include adrenocorticotropic hormone (ACTH), oral corticosteroids, and vigabatrin.
Henry Chen +13 more
doaj +2 more sources
Mean global field power is reduced in infantile epileptic spasms syndrome after response to vigabatrin [PDF]
Frontiers in NeurologyPurposeInfantile epileptic spasms syndrome (IESS) is associated with abnormal neuronal networks during a critical period of synaptogenesis and brain plasticity. Hypsarrhythmia is a visual EEG biomarker used to diagnose IESS, assess response to treatment,
Arjun Nair +4 more
doaj +2 more sources
Vigabatrin-induced retinal toxicity is partially mediated by signaling in rod and cone photoreceptors. [PDF]
PLoS ONE, 2012 Vigabatrin (VGB) is a commonly prescribed antiepileptic drug designed to inhibit GABA-transaminase, effectively halting seizures. Unfortunately, VGB treatment is also associated with the highest frequencies of peripheral visual field constriction of any ...
Jin Yang +7 more
doaj +3 more sources