Results 131 to 140 of about 1,375 (189)

The leaf idioblastome of the medicinal plant Catharanthus roseus is associated with stress resistance and alkaloid metabolism. [PDF]

open access: yesJ Exp Bot
Guedes JG   +8 more
europepmc   +1 more source

Formal Total Synthesis of (±)-Vindoline by Tandem Radical Cyclization

open access: yesOrganic Letters, 2002
A formal total synthesis of (+/-)-vindoline 1 has been achieved featuring the tandem cyclization of radicals produced from the iodoaryl azide 19a.
Murphy, J.A., Zhou, S., Bommezijn, S.
core   +9 more sources

Aspidosperma alkaloids. Conversion of tabersonine into vindoline

open access: yesJournal of the Chemical Society, Perkin Transactions 1, 1987
An efficient synthesis of vindoline, the indoline portion of the clinically useful antitumour agent vinblastine, starting from tabersonine is described.
B. DANIELI   +3 more
openaire   +4 more sources

Radioimmunoassay determination of vindoline

Phytochemistry, 1980
Abstract A radioimmunoassay (RIA) for the Aspidosperma alkaloid vindoline has been developed. Antibody production was achieved by injection of vindoline-bovine serum albumin conjugate into rabbits. The RIA method is specific and sensitive with detection limits of 5 ng of alkaloid.
Lewis S L Choi   +2 more
exaly   +2 more sources

Synthesis of the tricyclic core structure of vindoline

Tetrahedron Letters, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
Arthur G Schultz
exaly   +2 more sources

Mechanism of interaction of vinca alkaloids with tubulin: catharanthine and vindoline

open access: yesBiochemistry, 1991
The interactions of the vinca alkaloid drugs catharanthine and vindoline with tubulin have been investigated and compared with those of vinblastine and vincristine. Both drugs were found to be less effective in bringing about the inhibition of tubulin self-assembly into microtubules than vincristine and vinblastine, the drug to protein molar ratio ...
V, Prakash, S N, Timasheff
core   +4 more sources

Vindoline synthesis in in vitro shoot cultures of Catharanthus roseus

Biotechnology Letters, 2004
Vindoline, the major alkaloid in cultures of Catharanthus roseus shoots, reached 2 mg g(-1) dry wt after 27 d in culture. Maximal vindoline accumulation coincided with maximum activities of deacetoxyvindoline 4-hydroxylase, deacetylvindoline acetyl-CoA acetyl transferase and tryptophan decarboxylase.
Elizabeta Hernandez-Dominguez
exaly   +3 more sources

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