The leaf idioblastome of the medicinal plant Catharanthus roseus is associated with stress resistance and alkaloid metabolism. [PDF]
Guedes JG +8 more
europepmc +1 more source
Chrysin as a Bioactive Scaffold: Advances in Synthesis and Pharmacological Evaluation. [PDF]
Jeong CY, Kim CE, Byun EB, Jeon J.
europepmc +1 more source
Genome-Wide Survey of the Potential Function of CrLBDs in Catharanthus roseus MIA Biosynthesis. [PDF]
Chang C +6 more
europepmc +1 more source
Identification of Metabolites from Catharanthus roseus Leaves and Stem Extract, and In Vitro and In Silico Antibacterial Activity against Food Pathogens. [PDF]
Jamal QMS, Ahmad V.
europepmc +1 more source
Formal Total Synthesis of (±)-Vindoline by Tandem Radical Cyclization
A formal total synthesis of (+/-)-vindoline 1 has been achieved featuring the tandem cyclization of radicals produced from the iodoaryl azide 19a.
Murphy, J.A., Zhou, S., Bommezijn, S.
core +9 more sources
Aspidosperma alkaloids. Conversion of tabersonine into vindoline
An efficient synthesis of vindoline, the indoline portion of the clinically useful antitumour agent vinblastine, starting from tabersonine is described.
B. DANIELI +3 more
openaire +4 more sources
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Radioimmunoassay determination of vindoline
Phytochemistry, 1980Abstract A radioimmunoassay (RIA) for the Aspidosperma alkaloid vindoline has been developed. Antibody production was achieved by injection of vindoline-bovine serum albumin conjugate into rabbits. The RIA method is specific and sensitive with detection limits of 5 ng of alkaloid.
Lewis S L Choi +2 more
exaly +2 more sources
Synthesis of the tricyclic core structure of vindoline
Tetrahedron Letters, 2004AbstractFor Abstract see ChemInform Abstract in Full Text.
Arthur G Schultz
exaly +2 more sources
Mechanism of interaction of vinca alkaloids with tubulin: catharanthine and vindoline
The interactions of the vinca alkaloid drugs catharanthine and vindoline with tubulin have been investigated and compared with those of vinblastine and vincristine. Both drugs were found to be less effective in bringing about the inhibition of tubulin self-assembly into microtubules than vincristine and vinblastine, the drug to protein molar ratio ...
V, Prakash, S N, Timasheff
core +4 more sources
Vindoline synthesis in in vitro shoot cultures of Catharanthus roseus
Biotechnology Letters, 2004Vindoline, the major alkaloid in cultures of Catharanthus roseus shoots, reached 2 mg g(-1) dry wt after 27 d in culture. Maximal vindoline accumulation coincided with maximum activities of deacetoxyvindoline 4-hydroxylase, deacetylvindoline acetyl-CoA acetyl transferase and tryptophan decarboxylase.
Elizabeta Hernandez-Dominguez
exaly +3 more sources

