Results 151 to 160 of about 1,258 (192)
Some of the next articles are maybe not open access.
Aromatic Electrophilic Substitutions on Vindoline.
ChemInform, 2007AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Csaba Szántay +7 more
openaire +1 more source
Total synthesis of (−)-vindoline
Tetrahedron, 2019Abstract In this full paper, a stereocontrolled strategy for the total synthesis of (−)-vindoline is described. This synthetic route features: 1) rapid construction of the stereochemical center at C19 through a highly diastereoselective vinylogous Mannich addition; 2) tandem Heathcock/aza-Prins cyclization to install rings C and E in vindoline; 3 ...
Wen Chen +5 more
openaire +1 more source
Electro-Oligomerization of Vindoline
ECS Meeting Abstracts, 2020In a break from traditional oncolytic agents based on dimeric combinations [1] of catharanthine and vindoline [2] units, higher cytotoxicity of a designed dimeric vindoline is predicted [3] via its interfacial docking between α- and β-tubulins. Electrosynthesis potentially is a route to higher molecular weight analogs of vindoline.
openaire +1 more source
ChemInform Abstract: Synthesis of (‐)‐Vindoline.
ChemInform, 1987AbstractThe keto ester (VI) is synthesized as shown in the scheme.
P. L. FELDMAN, H. RAPOPORT
openaire +1 more source
A new oxidative rearrangement of vindoline
Tetrahedron Letters, 1989Abstract Oxidation of vindoline 1 with MnO2 yielded a rearranged product, the vincine derivative 5 , among other oxidized vindoline derivatives.
Hedvig Bölcskei +2 more
openaire +1 more source
PHOTOCHEMICAL OXIDATION OF VINDOLINE and 16‐O‐ACETYLVINDOLINE
Photochemistry and Photobiology, 1988Abstract— Photooxidation of 16‐O‐acetylvindoline in methanol using chlorpromazine‐HCl as a photosensitizing agent produces nearly quantitative yields of an iminium derivative. The 16‐O‐acetylvindol‐ine‐iminium product was characterized spectrally by proton NMR and mass spectrometry; and by chemical reduction with sodium borodeuteride.
F J, Filippelli +4 more
openaire +2 more sources
Pulsed Voltammetry of an Aspidosperma Alakaloid: Vindoline
ECS Meeting Abstracts, 2020There is steady interest in the chemistry surrounding vindoline [1] and its uses [2]. Of interest are the number of electron(s) involved in the electro-oxidation of its tertiary amine nitrogen and the dihydro-indole nitrogen. Normal pulse voltammetry (NPV) showed two successive one-electron removals respectively from the two nitrogens; essentially ...
Inam ul Haque +3 more
openaire +1 more source
Rearrangement of vindoline and derivatives in superacidic media
Tetrahedron, 1999Abstract In HF - SbF5 at O°C, vindoline 1a and its deacetyl derivative 1b yield the cathovaline like compounds 4 and 5 , respectively, and the furanic diastereoisomers 2 and 3 . Fluoro derivatives (20S)- 10b-d rearrange in superacids to 4 (92%), 5 (60%) and to lactone 11 (58%), respectively ...
Cécile Lafitte +3 more
openaire +1 more source
ChemInform Abstract: Vindoline and Its Reactions
ChemInform, 2012AbstractReview: 79 refs.
Inam‐Ul‐Haque Inam‐Ul‐Haque +1 more
openaire +1 more source
Vindoline and 16-demethoxyvindoline: two catharanthus-derived alkaloids
Acta Crystallographica Section C Crystal Structure Communications, 2004Vindoline, C(25)H(32)N(2)O(6), and 16-demethoxyvindoline, C(24)H(30)N(2)O(5), both of which are naturally occurring biologically active products derived from plants, are important as possible starting materials for the synthesis of valuable anticancer antibiotics, viz. vincristine and vinblastine, and other pharmaceuticals.
Joanna, Ruszkowska +3 more
openaire +2 more sources