Results 151 to 160 of about 1,375 (189)

Pulsed Voltammetry of an Aspidosperma Alakaloid: Vindoline

ECS Meeting Abstracts, 2020
There is steady interest in the chemistry surrounding vindoline [1] and its uses [2]. Of interest are the number of electron(s) involved in the electro-oxidation of its tertiary amine nitrogen and the dihydro-indole nitrogen. Normal pulse voltammetry (NPV) showed two successive one-electron removals respectively from the two nitrogens; essentially ...
Inam ul Haque, Muqaddas Tariq, Nishat Aslam, Hina Saba   +3 more
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A new oxidative rearrangement of vindoline

Tetrahedron Letters, 1989
Abstract Oxidation of vindoline 1 with MnO2 yielded a rearranged product, the vincine derivative 5 , among other oxidized vindoline derivatives.
Hedvig Bölcskei, Eszter Gács-Baitz, Csaba Szántay   +2 more
openaire   +1 more source

PHOTOCHEMICAL OXIDATION OF VINDOLINE and 16‐O‐ACETYLVINDOLINE

Photochemistry and Photobiology, 1988
Abstract— Photooxidation of 16‐O‐acetylvindoline in methanol using chlorpromazine‐HCl as a photosensitizing agent produces nearly quantitative yields of an iminium derivative. The 16‐O‐acetylvindol‐ine‐iminium product was characterized spectrally by proton NMR and mass spectrometry; and by chemical reduction with sodium borodeuteride.
F J, Filippelli, S E, Reeg, F S, Sariaslani, M W, Duffel, J P, Rosazza   +4 more
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ChemInform Abstract: Vindoline and Its Reactions

ChemInform, 2012
AbstractReview: 79 refs.
Inam‐Ul‐Haque Inam‐Ul‐Haque, Hina Saba   +1 more
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Rearrangement of vindoline and derivatives in superacidic media

Tetrahedron, 1999
Abstract In HF - SbF5 at O°C, vindoline 1a and its deacetyl derivative 1b yield the cathovaline like compounds 4 and 5 , respectively, and the furanic diastereoisomers 2 and 3 . Fluoro derivatives (20S)- 10b-d rearrange in superacids to 4 (92%), 5 (60%) and to lactone 11 (58%), respectively ...
Cécile Lafitte, Marie-Paule Jouannetaud, Jean-Claude Jacquesy, Alain Duflos   +3 more
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ChemInform Abstract: New Vindoline Derivatives.

ChemInform, 1987
AbstractSince some attempts to stereoselectively reduce the 17‐oxo group of the vindoline derivative (I) to the α‐alcohol have not been very successful, it is anticipated that the introduction of a bulky silyl group in C‐16 may render possible a specific synthesis of the desired alcohol.
R. Z. ANDRIAMIALISOA, A. CHIARONI, N. LANGLOIS, Y. LANGLOIS, C. RICHE   +4 more
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The Boger Synthesis of (-)-Vindoline

2013
The periwinkle-derived alkaloids vinblastine 2a and vincristine 2b are still mainstays of cancer chemotherapy. The more complex half of these dimeric alkaloids, vindoline 1, presents a formidable challenge for total synthesis. Building on his previous work (Organic Lett. 2005, 7, 4539), Dale L. Boger of Scripps/La Jolla devised (J. Am. Chem. Soc. 2010,
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Vindoline and 16-demethoxyvindoline: two catharanthus-derived alkaloids

Acta Crystallographica Section C Crystal Structure Communications, 2004
Vindoline, C(25)H(32)N(2)O(6), and 16-demethoxyvindoline, C(24)H(30)N(2)O(5), both of which are naturally occurring biologically active products derived from plants, are important as possible starting materials for the synthesis of valuable anticancer antibiotics, viz. vincristine and vinblastine, and other pharmaceuticals.
Joanna, Ruszkowska, Robert, Chrobak, Jan K, Maurin, Zbigniew, Czarnocki   +3 more
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Synthesis of Difluorocatharanthine and Investigation of its Biomimetic Coupling with Vindoline

Chemistry – A European Journal, 2012
International ...
Giovanelli, Emerson, Moisan, Lionel, Leroux, Sébastien, Comesse, Sébastien, Rousseau, Bernard, Hellier, Paul, Nicolas, Marc, Doris, Eric   +7 more
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Structure of the products of oxidation of vindoline by the Sarett reagent

Chemistry of Natural Compounds, 1988
The oxidation of vindoline with the Sarett reagent has given five lactams the structures of which have been established on the basis of the results of instrumental methods of analysis (the x-ray structural method, and the PMR, mass, and IR spectroscopy).
N. I. Zaletova, G. G. Aleksandrov, I. V. Yartseva, N. A. Klyuev, O. N. Tolkachev   +4 more
openaire   +1 more source