Results 141 to 150 of about 1,375 (189)
Spatial organization of the vindoline biosynthetic pathway in Catharanthus roseus
Journal of Plant Physiology, 2011 Vindoline constitutes the main terpenoid indole alkaloid accumulated in leaves of Catharanthus roseus, and four genes involved in its biosynthesis have been identified. However, the spatial organization of the tabersonine-to-vindoline biosynthetic pathway is still incomplete.
Guirimand, Grégory +7 more
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Spectroscopy Letters, 1989
Abstract Two Dimensional COSY and HETCOR experiments have been performed on the alkaloid vindoline which allow the complete 1zH and 13C spectral assignments to be made. Proton-proton and proton-carbon coupling constants are also given.
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Abstract Two Dimensional COSY and HETCOR experiments have been performed on the alkaloid vindoline which allow the complete 1zH and 13C spectral assignments to be made. Proton-proton and proton-carbon coupling constants are also given.
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The effect of conjugation on antitumor activity of vindoline derivatives with octaarginine, a cell-penetrating peptide [PDF]
Journal of Peptide Science, 2018 Some Vinca alkaloids (e.g. vinblastine, vincristine) have been widely used as antitumor drugs for a long time. Unfortunately, vindoline, a main alkaloid component of Catharanthus roseus (L.) G. Don, itself, has no antitumor activity.
Ferenc Hudecz +2 more
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An Efficient Total Synthesis of (-)-Vindoline
Synlett, 2000Tohru Fukuyama, Toshihiro Ueda
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Synthesis of Novel Vindoline‐Chrysin Hybrids
Chemistry & Biodiversity, 2021AbstractVinca alkaloids are well‐known microtubule targeting agents, which are used against some types of cancer. Vindoline is one of the monomeric Vinca alkaloids which does not have anti‐tumor effect, although its derivatives have serious impact on the field of these indole alkaloids.
Szabolcs Mayer +6 more
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Total synthesis of (−)-vindoline
Tetrahedron, 2019Abstract In this full paper, a stereocontrolled strategy for the total synthesis of (−)-vindoline is described. This synthetic route features: 1) rapid construction of the stereochemical center at C19 through a highly diastereoselective vinylogous Mannich addition; 2) tandem Heathcock/aza-Prins cyclization to install rings C and E in vindoline; 3 ...
Wen Chen +5 more
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Aromatic Electrophilic Substitutions on Vindoline.
ChemInform, 2007AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Csaba Szántay +7 more
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Vindoline effectively ameliorated diabetes-induced hepatotoxicity by docking oxidative stress, inflammation and hypertriglyceridemia in type 2 diabetes-induced male Wistar rats [PDF]
Biomedicine and Pharmacotherapy, 2019 ArticleVindoline, an indole alkaloid present in the leaves of Catharanthus roseus plant, has been recently reported to have insulotropic effects. This present study evaluated the possible hepatoprotective effects of vindoline in a type 2 diabetes ...
Yapo G Aboua +2 more
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Electro-Oligomerization of Vindoline
ECS Meeting Abstracts, 2020In a break from traditional oncolytic agents based on dimeric combinations [1] of catharanthine and vindoline [2] units, higher cytotoxicity of a designed dimeric vindoline is predicted [3] via its interfacial docking between α- and β-tubulins. Electrosynthesis potentially is a route to higher molecular weight analogs of vindoline.
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ChemInform Abstract: Synthesis of (‐)‐Vindoline.
ChemInform, 1987AbstractThe keto ester (VI) is synthesized as shown in the scheme.
P. L. FELDMAN, H. RAPOPORT
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