Results 141 to 150 of about 1,258 (192)
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Radioimmunoassay determination of vindoline
Phytochemistry, 1980Abstract A radioimmunoassay (RIA) for the Aspidosperma alkaloid vindoline has been developed. Antibody production was achieved by injection of vindoline-bovine serum albumin conjugate into rabbits. The RIA method is specific and sensitive with detection limits of 5 ng of alkaloid.
Lewis S L Choi, Brian R Worth
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Formal Total Synthesis of (±)-Vindoline by Tandem Radical Cyclization
Organic Letters, 2002 A formal total synthesis of (+/-)-vindoline 1 has been achieved featuring the tandem cyclization of radicals produced from the iodoaryl azide 19a.
Murphy, J.A., Zhou, S., Bommezijn, S.
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Synthesis of the tricyclic core structure of vindoline
Tetrahedron Letters, 2004AbstractFor Abstract see ChemInform Abstract in Full Text.
Arthur G Schultz
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Spectroscopy Letters, 1989
Abstract Two Dimensional COSY and HETCOR experiments have been performed on the alkaloid vindoline which allow the complete 1zH and 13C spectral assignments to be made. Proton-proton and proton-carbon coupling constants are also given.
Graham E Jackson
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Abstract Two Dimensional COSY and HETCOR experiments have been performed on the alkaloid vindoline which allow the complete 1zH and 13C spectral assignments to be made. Proton-proton and proton-carbon coupling constants are also given.
Graham E Jackson
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Vindoline synthesis in in vitro shoot cultures of Catharanthus roseus
Biotechnology Letters, 2004Vindoline, the major alkaloid in cultures of Catharanthus roseus shoots, reached 2 mg g(-1) dry wt after 27 d in culture. Maximal vindoline accumulation coincided with maximum activities of deacetoxyvindoline 4-hydroxylase, deacetylvindoline acetyl-CoA acetyl transferase and tryptophan decarboxylase.
Elizabeta Hernández-Domínguez +2 more
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Spatial organization of the vindoline biosynthetic pathway in Catharanthus roseus
Journal of Plant Physiology, 2011 Vindoline constitutes the main terpenoid indole alkaloid accumulated in leaves of Catharanthus roseus, and four genes involved in its biosynthesis have been identified. However, the spatial organization of the tabersonine-to-vindoline biosynthetic pathway is still incomplete.
Guirimand, Grégory +7 more
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Mechanism of interaction of vinca alkaloids with tubulin: catharanthine and vindoline
Biochemistry, 1991 The interactions of the vinca alkaloid drugs catharanthine and vindoline with tubulin have been investigated and compared with those of vinblastine and vincristine. Both drugs were found to be less effective in bringing about the inhibition of tubulin self-assembly into microtubules than vincristine and vinblastine, the drug to protein molar ratio ...
V, Prakash, S N, Timasheff
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The effect of conjugation on antitumor activity of vindoline derivatives with octaarginine, a cell‐penetrating peptide [PDF]
Journal of Peptide Science, 2018 Some Vinca alkaloids (e.g. vinblastine, vincristine) have been widely used as antitumor drugs for a long time. Unfortunately, vindoline, a main alkaloid component of Catharanthus roseus (L.) G. Don, itself, has no antitumor activity.
Zoltan Banoczi +2 more
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Synthesis of Novel Vindoline‐Chrysin Hybrids
Chemistry & Biodiversity, 2021AbstractVinca alkaloids are well‐known microtubule targeting agents, which are used against some types of cancer. Vindoline is one of the monomeric Vinca alkaloids which does not have anti‐tumor effect, although its derivatives have serious impact on the field of these indole alkaloids.
Szabolcs Mayer +6 more
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Vindoline effectively ameliorated diabetes-induced hepatotoxicity by docking oxidative stress, inflammation and hypertriglyceridemia in type 2 diabetes-induced male Wistar rats [PDF]
Biomedicine and Pharmacotherapy, 2019 ArticleVindoline, an indole alkaloid present in the leaves of Catharanthus roseus plant, has been recently reported to have insulotropic effects. This present study evaluated the possible hepatoprotective effects of vindoline in a type 2 diabetes ...
Mediline Goboza +2 more
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