Results 161 to 170 of about 2,154 (205)

ChemInform Abstract: Synthesis of (‐)‐Vindoline.

ChemInform, 1987
AbstractThe keto ester (VI) is synthesized as shown in the scheme.
P. L. FELDMAN, H. RAPOPORT
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Aspidosperma alkaloids. Conversion of tabersonine into vindoline

Journal of the Chemical Society, Perkin Transactions 1, 1987
An efficient synthesis of vindoline, the indoline portion of the clinically useful antitumour agent vinblastine, starting from tabersonine is described.
B. DANIELI, G. LESMA, G. PALMISANO, RIVA, RENATA   +3 more
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Electro-Oligomerization of Vindoline

ECS Meeting Abstracts, 2020
In a break from traditional oncolytic agents based on dimeric combinations [1] of catharanthine and vindoline [2] units, higher cytotoxicity of a designed dimeric vindoline is predicted [3] via its interfacial docking between α- and β-tubulins. Electrosynthesis potentially is a route to higher molecular weight analogs of vindoline.
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ChemInform Abstract: New Vindoline Derivatives.

ChemInform, 1987
AbstractSince some attempts to stereoselectively reduce the 17‐oxo group of the vindoline derivative (I) to the α‐alcohol have not been very successful, it is anticipated that the introduction of a bulky silyl group in C‐16 may render possible a specific synthesis of the desired alcohol.
R. Z. ANDRIAMIALISOA, A. CHIARONI, N. LANGLOIS, Y. LANGLOIS, C. RICHE   +4 more
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PHOTOCHEMICAL OXIDATION OF VINDOLINE and 16‐O‐ACETYLVINDOLINE

Photochemistry and Photobiology, 1988
Abstract— Photooxidation of 16‐O‐acetylvindoline in methanol using chlorpromazine‐HCl as a photosensitizing agent produces nearly quantitative yields of an iminium derivative. The 16‐O‐acetylvindol‐ine‐iminium product was characterized spectrally by proton NMR and mass spectrometry; and by chemical reduction with sodium borodeuteride.
F J, Filippelli, S E, Reeg, F S, Sariaslani, M W, Duffel, J P, Rosazza   +4 more
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Pulsed Voltammetry of an Aspidosperma Alakaloid: Vindoline

ECS Meeting Abstracts, 2020
There is steady interest in the chemistry surrounding vindoline [1] and its uses [2]. Of interest are the number of electron(s) involved in the electro-oxidation of its tertiary amine nitrogen and the dihydro-indole nitrogen. Normal pulse voltammetry (NPV) showed two successive one-electron removals respectively from the two nitrogens; essentially ...
Inam ul Haque, Muqaddas Tariq, Nishat Aslam, Hina Saba   +3 more
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Vindoline and 16-demethoxyvindoline: two catharanthus-derived alkaloids

Acta Crystallographica Section C Crystal Structure Communications, 2004
Vindoline, C(25)H(32)N(2)O(6), and 16-demethoxyvindoline, C(24)H(30)N(2)O(5), both of which are naturally occurring biologically active products derived from plants, are important as possible starting materials for the synthesis of valuable anticancer antibiotics, viz. vincristine and vinblastine, and other pharmaceuticals.
Joanna, Ruszkowska, Robert, Chrobak, Jan K, Maurin, Zbigniew, Czarnocki   +3 more
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A new oxidative rearrangement of vindoline

Tetrahedron Letters, 1989
Abstract Oxidation of vindoline 1 with MnO2 yielded a rearranged product, the vincine derivative 5 , among other oxidized vindoline derivatives.
Hedvig Bölcskei, Eszter Gács-Baitz, Csaba Szántay   +2 more
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ChemInform Abstract: Vindoline and Its Reactions

ChemInform, 2012
AbstractReview: 79 refs.
Inam‐Ul‐Haque Inam‐Ul‐Haque, Hina Saba   +1 more
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Isolation, purification and characterization of vindoline from Catharanthus roseus

International Journal of Science and Research Archive, 2023
Catharanthus roseus is a popular medicinal plant available all over the world. Across the globe, different parts of the plant are used to treat diabetes, hypertension, cancer, and menstrual abnormalities. In the current study, aim was to isolate, purify and characterize vindoline from the aerial parts (stem, leaves and flowers) of C.roseus.
null Raghu Nataraj, null Jagadish MS, null Kavitha Raj Varadaraju, null Bindu J   +3 more
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