Results 71 to 80 of about 27,363 (202)

Emerging Strategies in the Diagnosis and Treatment of Pleural Mesothelioma: An Overview

Thoracic Cancer, Volume 17, Issue 8, April 2026.
This review examines pleural mesothelioma, from risk factors and pathogenesis to diagnostic approaches and histological classification. We discuss current treatment strategies including chemotherapy and FDA‐approved immunotherapy, alongside emerging therapies such as VISTA, LAG‐3 inhibitors, and dendritic cell‐based approaches for personalized ...
Raffaella Pagliaro, Beatrice Leonardi, Angela Schiattarella, Grazia Bergameo, Carmine Picone, Adolfo Gallipoli D'Errico, Filippo Scialò, Fabio Perrotta, Maria Luisa De Rimini, Alfonso Fiorelli, Andrea Bianco   +10 more
wiley   +1 more source

Vinorelbine- Autophagy Agent Combinations Induce Synergistic Cytotoxicity in SH-SY5Y Neuroblastoma Cells

Recent Trends in Pharmacology
Objective: To investigate whether pharmacological agents associated with autophagy induction or inhibition modulate vinorelbine-induced cytotoxic responses in SH-SY5Y neuroblastoma cells.
Berna Yıldırım, Melike Seçilmiş, Burcu Biltekin, Mete Hakan Karalök, Turgay Barut, Ayhan Bilir   +5 more
doaj   +1 more source

Neoadjuvant Combination Chemotherapy with Pegylated Liposomal Doxorubicin and Vinorelbine for Locally Advanced Breast Cancer

Cancer Biology & Medicine, 2010
OBJECTIVE In China, vinorelbine plus an anthracycline is a common neoadjuvant regimen for locally-advanced breast cancer (LABC). Pegylated liposomal doxorubicin (PLD) is an alternate anthracycline formulation with a more favorable safety profi le ...
Zhen-zhou SHEN, Zhi-min SHAO, Bing-he XU
doaj   +1 more source

Addition of Immune Checkpoint Inhibitor to Platinum Retreatment for Recurrent Non‐Small Cell Lung Cancer After Perioperative Chemotherapy: A Multicenter Retrospective Study

Thoracic Cancer, Volume 17, Issue 7, April 2026.
We retrospectively analyzed 31 patients with NSCLC treated with platinum retreatment who relapsed after perioperative platinum therapy and surgery. PFS was significantly longer in the ICI‐chemo group than in the chemo group. Adding ICI to platinum retreatment may be an effective option for this population.
Toshiaki Takakura, Ryota Shibaki, Atsushi Washioka, Yusuke Murakami, Yuhei Harutani, Hiroaki Akamatsu, Nobuyuki Yamamoto   +6 more
wiley   +1 more source

Efficacy of the combination of cisplatin with either gemcitabine and vinorelbine or gemcitabine and paclitaxel in the treatment of locally advanced or metastatic non-small-cell lung cancer: a phase III randomised trial of the Southern Italy Cooperative Oncology Group (SICOG 0101) [PDF]

, 2007
Triplet regimens were occasionally reported to produce a higher response rate (RR) than doublets in locally advanced or metastatic non-small-cell lung cancer (NSCLC).
Bianco, M, Buzzi, F, Cioffi, R, Comella, P, De Cataldis, G, Filippelli, G, Frasci, G, Gambardella, A, Ghiani, M, Maiorino, L, Mancarella, S, Massidda, B, Masullo, P, Milia, V, Natale, D, Palmeri, S, Putzu, C, Roselli, M   +17 more
core   +1 more source

Comparing the Prognosis of Non‐Small Cell Lung Cancer Patients Who Did Not Undergo Surgery After Neoadjuvant Chemotherapy Combined With Immunotherapy: A Retrospective Study

Thoracic Cancer, Volume 17, Issue 7, April 2026.
This study retrospectively investigated the prognosis of NSCLC patients who did not undergo surgery after NACI. The patients were grouped based on their subsequent treatment: RTG or non‐RTG, and the importance of PET/CT in predicting prognosis was further evaluated.
Zhenghui Ma, Yuqi Wu, Guangqian Ji, Zongmei Zhou, Xin Wang, Jianyang Wang, Wenyang Liu, Lei Deng, Wenqing Wang, Junlin Yi, Nan Bi, Tao Zhang   +11 more
wiley   +1 more source

Vinca Alkaloids

International Journal of Preventive Medicine, 2013
Vinca alkaloids are a subset of drugs obtained from the Madagascar periwinkle plant. They are naturally extracted from the pink periwinkle plant, Catharanthus roseus G. Don and have a hypoglycemic as well as cytotoxic effects.
Maryam Moudi, Rusea Go, Christina Yong Seok Yien, Mohd Nazre   +3 more
doaj  

A Phase I Comparative Pharmacokinetic and Safety Study of Two Intravenous Formulations of Vinorelbine in Patients With Advanced Non-Small Cell Lung Cancer

Frontiers in Pharmacology, 2019
Purpose: The aim of this study was to compare the pharmacokinetics and safety between two vinorelbine formulations [a new oil-in-water emulsion formulation (ANX) versus a previously marketed solution formulation (Navelbine)] in Chinese patients with ...
Guolan Wu, Guolan Wu, Lihua Wu, Lihua Wu, Huili Zhou, Huili Zhou, Meihua Lin, Meihua Lin, Ling Peng, Yina Wang, You Zhai, You Zhai, Xingjiang Hu, Xingjiang Hu, Yunliang Zheng, Yunliang Zheng, Duo Lv, Duo Lv, Jian Liu, Jian Liu, Jianzhong Shentu, Jianzhong Shentu   +21 more
doaj   +1 more source

Prognostic role of PET/CT volumetric parameters in paediatric Hodgkin lymphoma: A systematic review and expert recommendations from the International SEARCH for CAYAHL Group

British Journal of Haematology, Volume 208, Issue 4, Page 1185-1195, April 2026.
A visual overview of the key findings from the 35 papers included in this systematic review evaluating the use of PET volumetric parameters in children, adolescents and young adults with Hodgkin lymphoma. Summary In adults with classic Hodgkin lymphoma (cHL), metabolic tumour volume (MTV) is valuable for risk stratification.
S. Claire Gowdy, Jamie E. Flerlage, Jennifer Seelisch, Monica Palese, Tyler Bradshaw, Sharon M. Castellino, Steve Cho, Karin Dieckmann, Bradford S. Hoppe, Scott Howard, Kara M. Kelly, Lars Kurch, Hollie A. Lai, Egesta Lopci, John T. Lucas Jr., Christine Mauz‐Körholz, Kathleen M. McCarten, Neeta Pandit‐Taskar, Heiko Schöder, Jonas Steglich, Dietrich Stoevesandt, Stephan D. Voss, Sarah A. Milgrom   +22 more
wiley   +1 more source

Vinorelbine causes a neuropathic pain-like state in mice via STING and MNK1 signaling associated with type I interferon induction

iScience
Summary: Type I interferons (IFNs) increase the excitability of dorsal root ganglia (DRGs) neurons via MNK-eIF4E signaling to promote pain sensitization in mice.
Úrzula Franco-Enzástiga, Keerthana Natarajan, Eric T. David, Krish Patel, Abhira Ravirala, Theodore J. Price   +5 more
doaj   +1 more source