Results 81 to 90 of about 27,363 (202)

Vinorelbine as a radiosensitizer in Pakistani patients with locally advanced unresectable head & neck cancer (HNC) in tertiary care hospital of Pakistan

International Journal of Endorsing Health Science Research, 2019
Background: Head and neck cancer (HNC) is one of the most common cancers in Pakistan. Disease free survival in HNC remains poor due to inefficient loco-regional disease control. The aim of the present study was to assess the response rate and toxicity of
Rana Atique Anwer Khan, Ahmed Ijaz Masood, Sadaqat Ali Gorchani, Muhammad Junaid, Ali Yasir Khan   +4 more
doaj   +1 more source

Dose selection trial of metronomic oral vinorelbine monotherapy in patients with metastatic cancer: a hellenic cooperative oncology group clinical translational study [PDF]

, 2013
BACKGROUND: Metronomic chemotherapy is considered an anti-angiogenic therapy that involves chronic administration of low-dose chemotherapy at regular short intervals.
Antonios Vassias, Eirini Biziota, Epaminontas Samantas, Evangelos Briasoulis, George Fountzilas, George Klouvas, George Kouvatseas, Gerasimos Aravantinos, Haralambos Kalofonos, Ioannis Boukovinas, Ioannis Sainis, Ioannis Varthalitis, Ioannis Xanthakis, Kostantinos N Syrigos, Periklis Pappas, Thomas Makatsoris   +15 more
core   +1 more source

Efficacy of immune checkpoint inhibitors in paediatric, adolescent and young adults with primary refractory or relapsed classical Hodgkin lymphoma: A national multicentre real‐world study

British Journal of Haematology, Volume 208, Issue 4, Page 1331-1338, April 2026.
Summary Classical Hodgkin lymphoma (cHL) is the most frequent lymphoma in children, adolescents and young adults (CAYA). Despite therapeutic advances, around 15% of patients relapse or have refractory (R/R) disease. Conventional salvage regimens remain effective but are associated with substantial long‐term toxicity. Immune checkpoint inhibitors (CPIs),
Marlène Pouthier, Nathalie Garnier, Amaury Leruste, Charlotte Rigaud, Catherine Curtillet, Stéphane Ducassou, Marilyne Poirée, Marie‐Emilie Dourthe, Cécile Pochon, Marie‐Laure Couec, Jacinthe Bonneau‐Lagacherie, Françoise Montravers, Sabah Boudjemaa, Bénédicte Jonca, Stéphanie Haouy, Thierry Leblanc, Judith Landman Parker, Mathieu Simonin   +17 more
wiley   +1 more source

Inactivation of CDK12 Enhances Mitochondrial Efficiency to Suppress DNA Damage

Journal of Cellular and Molecular Medicine, Volume 30, Issue 7, April 2026.
ABSTRACT Inactivation of cyclin‐dependent kinase 12 (CDK12) characterizes a subset of prostate cancers but it is not understood how cells adapt to declining activity of this major transcription elongation kinase. To probe this response, we developed a cell line resistant to an inhibitor targeting CDK12 and its paralog, CDK13.
Aishwarya Gondane, Shivani Yalala, Jing Liang, Sonja Saira, Harri M. Itkonen   +4 more
wiley   +1 more source

Oral vinorelbine: its role in advanced breast cancer pre-treated with anthracycline and taxane chemotherapies

Oncology Reviews, 2011
Metastatic breast cancer (BC) remains an incurable disease and clinical benefit and prolongation of time to progression are the main end-points in advanced setting. A safe and feasible schedule of administration is the principal option in pre-treated and
Fausto Petrelli, Sandro Barni
doaj   +1 more source

Current Exercise Behaviors of Breast Cancer Patients Diagnosed with Chemotherapy-Induced Peripheral Neuropathy

, 2012
Introduction: Chemotherapy-induced peripheral neuropathy (CIPN) is a common, dose-limiting effect of cancer therapy. The neuropathic pain associated with CIPN often has negative implications on an individual’s quality of life (QOL) and has long been ...
Drury, Daniel G., Wonders, Karen Y.
core   +1 more source

Customized chemotherapy based on epidermal growth factor receptormutation status for elderly patients with advanced non-small-cell lung cancer: a phase II trial [PDF]

, 2012
BACKGROUND: Elderly patients are more vulnerable to toxicity from chemotherapy. Activating epidermal growth factor receptor (EGFR) mutations in non-small-cell lung cancer (NSCLC) are associated with enhanced response to EGFR tyrosine-kinase inhibitors ...
Hiroshige Yoshioka, Katsuhiro Masago, Kei Kunimasa, Keisuke Tomii, Masataka Hirabayashi, Nobuyuki Katakami, Shiro Fujita, Tadashi Mio, Toshihiko Kaneda, Toshio Morizane   +9 more
core   +1 more source

Single‐Cell Transcriptomic Analysis of Chemotherapy‐Induced Changes in Osteosarcoma With a Pyroptosis‐Related Gene‐Based Prognostic Model

Journal of Cellular and Molecular Medicine, Volume 30, Issue 7, April 2026.
ABSTRACT Osteosarcoma, the most common primary malignant bone tumour, presents significant treatment challenges due to its complex tumour microenvironment and the development of chemoresistance. This study employs single‐cell transcriptomics to investigate chemotherapy‐induced changes in osteosarcoma at both the cellular and molecular levels.
Tao Jin, Lei Dong, Wang Kai, Ziyang Yu, Guoyong Yu, Weifeng Liu   +5 more
wiley   +1 more source

Vinorelbine-based salvage therapy in HER2-positive metastatic breast cancer patients progressing during trastuzumab-containing regimens: a retrospective study

BMC Cancer, 2008
Background The vinka-alkaloyd vinorelbine is a potentially valuable treatment in patients with HER2-positive, trastuzumab-resistant advanced breast cancer.
Viale Giuseppe, Valabrega Giorgio, Jacomuzzzi Maria, Donadio Michela, Nolè Franco, Redana Stefania, Montemurro Filippo, Sapino Anna, Aglietta Massimo   +8 more
doaj   +1 more source

Neutrophil gelatinase-associated lipocalin (NGAL) predicts response to neoadjuvant chemotherapy and clinical outcome in primary human breast cancer [PDF]

, 2012
In our previous work we showed that NGAL, a protein involved in the regulation of proliferation and differentiation, is overexpressed in human breast cancer (BC) and predicts poor prognosis.
Arnold, Norbert, Ataseven, Beyhan, Bauer, Maret, Darb-Esfahani, Silvia, Denkert, Carsten Michael, Hamann, Sigrid, Holzhausen, Hans-Jürgen, Jonat, Walter, Khandan, Fariba, Loibl, Sibylle, Mehta, Keyur, Minckwitz, Gunther von, Mundhenke, Christoph, Müller, Berit, Park, Hyerim, Schem, Christian, Thomssen, Christoph, Weimer, Joerg, Wenners, Antonia Sophie   +18 more
core   +2 more sources