Results 21 to 30 of about 240,853 (262)

Rhinovirus Biology, Antigenic Diversity, and Advancements in the Design of a Human Rhinovirus Vaccine

Frontiers in Microbiology, 2017
Human rhinovirus (HRV) remains a leading cause of several human diseases including the common cold. Despite considerable research over the last 60 years, development of an effective vaccine to HRV has been viewed by many as unfeasible due, in part, to ...
Christopher C. Stobart, Jenna M. Nosek, Martin L. Moore, Martin L. Moore   +3 more
doaj   +1 more source

Viral Complexity

Biomolecules, 2022
Although traditionally viewed as streamlined and simple, discoveries over the last century have revealed that viruses can exhibit surprisingly complex physical structures, genomic organization, ecological interactions, and evolutionary histories. Viruses
Frank O. Aylward, Mohammad Moniruzzaman
doaj   +1 more source

Alpha/beta and gamma interferons are induced by infection with noncytopathic bovine viral diarrhea virus in vivo [PDF]

, 2002
In contrast to the results of previous in vitro studies, experimental infection of calves with noncytopathic bovine viral diarrhea virus (ncpBVDV) was found to induce strong alpha/beta and gamma interferon responses in gnotobiotic animals.
Carr, B V, Howard, CJ, Brackenbury, L.S, Fray, M D, Morrison, Ivan, Charleston, B, Hope, Jayne; id_orcid   +6 more
core   +1 more source

Norovirus Epidemiology and Genetic Diversity in Leipzig, Germany during 2013–2017

Viruses, 2021
Globally and in all age groups, noroviruses are a main cause of gastroenteritis. To assess their local epidemiology and genetic diversity, stool samples of 7509 inpatients with gastrointestinal complaints from all age groups were analyzed.
Nora Ennuschat, Sabine Härtel, Corinna Pietsch, Uwe G. Liebert   +3 more
doaj   +1 more source

High Transcriptional Activity and Diverse Functional Repertoires of Hundreds of Giant Viruses in a Coastal Marine System

mSystems, 2021
Viruses belonging to the Nucleocytoviricota phylum are globally distributed and include members with notably large genomes and complex functional repertoires.
Anh D. Ha, Mohammad Moniruzzaman, Frank O. Aylward   +2 more
doaj   +1 more source

Dominant-Negative Proteins in Herpesviruses - From Assigning Gene Function to Intracellular Immunization [PDF]

, 2009
Investigating and assigning gene functions of herpesviruses is a process, which profits from consistent technical innovation. Cloning of bacterial artificial chromosomes encoding herpesvirus genomes permits nearly unlimited possibilities in the ...
Christian A. Mohr, Ulrich Koszinowski, Mühlbach, Hermine, Koszinowski, Ulrich H., Zsolt Ruzsics, Christian Mohr, Mohr, Christian A., Ruzsics, Zsolt, Hermine Mühlbach, Ulrich H. Koszinowski   +9 more
core   +1 more source

Viromes of Coastal Waters of the North Caspian Sea: Initial Assessment of Diversity and Functional Potential

Diversity, 2023
In recent years, the study of marine viromes has become one of the most relevant areas of geoecology. Viruses are the most numerous, genetically diverse and pervasive biological entities on Earth, including in aquatic ecosystems.
Madina S. Alexyuk, Yurij S. Bukin, Tatyana V. Butina, Pavel G. Alexyuk, Vladimir E. Berezin, Andrey P. Bogoyavlenskiy   +5 more
doaj   +1 more source

Genetic Analysis of SARS-CoV-2 Variants in Mexico during the First Year of the COVID-19 Pandemic

Viruses, 2021
During the first year of the SARS-CoV-2 pandemic in Mexico, more than two million people were infected. In this study, we analyzed full genome sequences from 27 February 2020 to 28 February 2021 to characterize the geographical and temporal distribution ...
Blanca Taboada, Selene Zárate, Pavel Iša, Celia Boukadida, Joel Armando Vazquez-Perez, José Esteban Muñoz-Medina, José Ernesto Ramírez-González, Andreu Comas-García, Concepción Grajales-Muñiz, Alma Rincón-Rubio, Margarita Matías-Florentino, Alejandro Sanchez-Flores, Edgar Mendieta-Condado, Jerome Verleyen, Gisela Barrera-Badillo, Lucía Hernández-Rivas, Fidencio Mejía-Nepomuceno, José Arturo Martínez-Orozco, Eduardo Becerril-Vargas, Susana López, Irma López-Martínez, Santiago Ávila-Ríos, Carlos F. Arias   +22 more
doaj   +1 more source

Constrained pattern of viral evolution in acute and early HCV infection limits viral plasticity

, 2011
Cellular immune responses during acute Hepatitis C virus (HCV) and HIV infection are a known correlate of infection outcome. Viral adaptation to these responses via mutation(s) within CD8+ T-cell epitopes allows these viruses to subvert host immune ...
Paul Klenerman, Malte Heeg, John, Mina, Pfafferott, K, James, Ian, Ulsenheimer, Axel, Helmut M. Diepolder, Lucas, A.D., Silvana Gaudieri, Heeg, M, Rauch, A, Ian James, John, M., Andri Rauch, Klenerman, P., James, I, Simon Mallal, Diepolder, HM, Heeg, Malte, John, M, Mallal, Simon, Lucas, Andrew, Nolan, D., Lucas, M., Heeg, M., Michaela Lucas, Diepolder, H.M., Mallal, S., Gaudieri, S, Lucas, M, Gaudieri, S., Nolan, David, Ulsenheimer, A, Lucas, A, David Nolan, Klenerman, Paul, Diepolder, Helmut M., Pfafferott, K., Klenerman, P, Rauch, A., Ulsenheimer, A., Pfafferott, Katja, Lucas, Michaela, Katja Pfafferott, Andrew Lucas, Rauch, Andri, Diepolder, Helmut M, Axel Ulsenheimer, Mina John, Helmut M Diepolder, Nolan, D, Mallal, S, James, I., Gaudieri, Silvana   +53 more
core   +1 more source

Observing micro-evolutionary processes of viral populations at multiple scales [PDF]

, 2013
Advances in sequencing technology coupled with new integrative approaches to data analysis provide a potentially transformative opportunity to use pathogen genome data to advance our understanding of transmission.
Orton, Richard J., Valdazo-Gonzalez, B., King, D.P., Knowles, N.J., Morelli, M.J., Morelli, Marco J., Wright, Caroline F., Haydon, D.T., Juleff, N., Wright, C.F., Paton, D.J., Orton, R.J., Valdazo-Gonzáles, Begoña, Thébaud, Gael, Thebaud, G., Paton, David J., Juleff, Nicholas, King, Donald P., Haydon, Daniel T., Knowles, Nick J.   +19 more
core   +1 more source