Results 81 to 90 of about 60,752 (282)

Deep Contrastive Learning for High‐Throughput Prediction of Drug Resistance Mutations from Sequences

Advanced Science, EarlyView.
This study presents DeepMutDTA, a deep learning framework aimed at predicting mutation‐induced changes in protein‐drug interactions and prioritizing variants potentially linked to drug resistance. Trained on large‐scale data, it incorporates SimSiam‐MuTF, a label‐aware contrastive fine‐tuning strategy that encourages separation between WT and MT ...
Xiaowen Hu, Pan Zhang, Shangqian Wu, Hao Sun, Minwei Li, Sophia Tsoka, Zizhang Sheng, Lei Deng   +7 more
wiley   +1 more source

Evolving landscape of viral infections in Pakistan: A comprehensive review of current surveillance, emerging threats and changing epidemiological patterns

Pakistan Journal of Pathology
Objective: Pakistan faces several challenges from endemic and emerging viral threats owing to its unique geographical location. Several factors including climatic conditions, socioeconomic challenges, urban overcrowding and travel, overwhelm the already fragile national healthcare system of the country.
Moiz Khan, Syeda Bushra Fatima, Victor Basheer, Margaret Palous, Naseem Shiraz, Naseem Shiraz   +5 more
openaire   +1 more source

The Emergence of Saliva as a Diagnostic and Prognostic Tool for Viral Infections

Saliva has emerged as a promising diagnostic fluid for viral infections, enabling the direct analysis of viral genetic material and the detection of infection markers such as proteins, metabolites, microRNAs, and immunoglobulins.
Rafael Antônio Velôso Caixeta, Debora Pallos, Simone Giannecchini, Matheus Willian Caetano, Juan Aitken-Saavedra, André Luiz Ferreira Costa, Paulo Henrique Braz-Silva, Nilson Ferreira de Oliveira Neto, Amanda Caroline Zarpellon, Rodrigo Melim Zerbinati, Roger Junges   +10 more
core   +1 more source

A Unifying Scenario on the Origin and Evolution of Cellular and Viral Domains [PDF]

, 2009
The cellular theory on the nature of life has been one of the first major advancements in biology. Viruses, however, are the most abundant life forms, and their exclusion from mainstream biology and the Tree of Life (TOL) is a major paradox in biology ...
Claudiu I. Bandea
core  

Improving risk assessment of the emergence of novel influenza A viruses by incorporating environmental surveillance [PDF]

, 2019
Reassortment is an evolutionary mechanism by which influenza A viruses (IAV) generate genetic novelty. Reassortment is an important driver of host jumps and is widespread according to retrospective surveillance studies.However, predicting the ...
Abdo, Zaid, Lloyd-Smith, James O., Piaggio, Antoinette J., Hopken, Matthew, Spackman, Erica, Riley, Steven, Pepin, Kim M., Piaggio, Antoinette, Shriner, Susan, Pepin, Kim, Hopken, Matthew W., Steven, Steven, Parrish, Colin, Shriner, Susan A., Lloyd-Smith, James   +14 more
core   +1 more source

Modulation of miR‐23b Wnt/β‐catenin Axis Strengthens Endothelial Barrier Properties

Advanced Science, EarlyView.
Early blood‐brain barrier (BBB) disruption contributes to stroke and CNS disease pathology. miR‐23b was identified as a regulator of BBB integrity in brain endothelial cells. Inhibition of miR‐23b enhanced barrier‐associated properties, promoted repair‐related signaling, and reduced BBB leakage in experimental stroke models, supporting further ...
Victor Anthony Martinez, Rose E. Presby, Sara Nakanishi, Pallavi Gaur, Ugur Akcan, Johannes Daugaard Krog, Iben Daugaard Krog, Lipi Das, David S. Johnson, Danny Jamoul, Douglas Jury, Brian Lawson, Jacob Körbelin, Lewis M. Brown, Vilas Menon, Dritan Agalliu, Irene Munk Pedersen   +16 more
wiley   +1 more source

A review on monitoring emerging viruses in Indonesia in the post-COVID-19 era

Discover Viruses
The emergence of new zoonotic viruses such as SARS-CoV has been a concern for public health since the 1990s. The latest COVID-19 outbreak has proven to be a devastating threat not only to human survival but also to national economies in the 21st century.
Ageng Wiyatno, Khin Saw Myint, I. Made Artika, Aghnianditya Kresno Dewantari, Korri El Khobar, Amalina Ghaisani Komarudin, Amin Soebandrio, Dodi Safari   +7 more
doaj   +1 more source

Genomics-based approach for detection and characterization of SARS-CoV-2 co-infections and diverse viral populations

Microbiology Spectrum
Due to the continuous genetic diversification of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) over time, the co-circulation of two different lineages in the same region may lead to co-infections within a host, a situation known to ...
Bryan Jimenez-Araya, Aurélie Gourgeon, Mélissa N'Debi, Taylor Thompson, Vanessa Demontant, Axel Simitambe, Michel Lau, Laure Boizeau, Patrice Bruscella, Pierre Cappy, Jean-Michel Pawlotsky, Slim Fourati, Christophe Rodriguez   +12 more
doaj   +1 more source

A participatory epidemiological and One Health approach to explore the community’s capacity to detect emerging zoonoses and surveillance network opportunities in the forest region of Guinea

PLoS Neglected Tropical Diseases, 2022
The Ebola virus disease epidemic that threatened West Africa between 2013 and 2016 was of unprecedented health magnitude. After this health crisis, studies highlighted the need to introduce community-based surveillance systems and to adopt a One Health ...
Marie-Jeanne Guenin, Hélène Marie De Nys, Marisa Peyre, Etienne Loire, Suporn Thongyuan, Abdoulaye Diallo, Léonce Zogbelemou, Flavie Luce Goutard   +7 more
doaj  

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

Advanced Science, EarlyView.
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes, Gabriela Silva, Mafalda Aleixo, Marta Gomes, Daniel Simão, Stephan J. Holtkamp, Diana D. Lobo, Pradeep Harish, Rosalind Jenkins, Lekh N. Dahal, Rui J. Nobre, Luís de Pereira de Almeida, Mark Trautwein, Paula M. Alves, Catarina Brito   +14 more
wiley   +1 more source