Results 61 to 70 of about 60,752 (282)

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Longitudinal genomic surveillance of SARS-CoV-2 in a university microcosm reflects global evolutionary trends

Microbiology Spectrum
SARS-CoV-2 transmission has declined, yet ongoing viral evolution continues to pose public health challenges. This study conducted long-term (2020–2024) genomic surveillance within a large and globally diverse university community. Viral genomes obtained
Sankar Prasad Chaki, Melissa M. Kahl-McDonagh, Benjamin W. Neuman, Loni A. Taylor, Rebecca S. B. Fischer, Blake M. Hanson, Marlisa S. Hardy, Jo Ann Culpepper, Eric Boerwinkle, Kurt A. Zuelke   +9 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Early detection of emerging viral variants through analysis of community structure of coordinated substitution networks

Nature Communications
The emergence of viral variants with altered phenotypes is a public health challenge underscoring the need for advanced evolutionary forecasting methods.
Fatemeh Mohebbi, Alex Zelikovsky, Serghei Mangul, Gerardo Chowell, Pavel Skums   +4 more
doaj   +1 more source

Mexico as a hotspot for plant virus evolution: eco-evolutionary regimes shaping viral emergence

Frontiers in Plant Science
Plant virus and viroid emergence in Mexico reflects the operation of distinct eco-evolutionary regimes rather than isolated epidemiological events.
Flor C. Alcántar-Aguirre, Erika J. Zamora-Macorra, Ubilfrido V. Gutiérrez, Jimena Carrillo-Tripp, Alfredo Diaz-Lara, Katia Aviña-Padilla   +5 more
doaj   +1 more source

Investigating the evolutionary origins of the first three SARS-CoV-2 variants of concern

Frontiers in Virology, 2022
The emergence of Variants of Concern (VOCs) of SARS-CoV-2 with increased transmissibility, immune evasion properties, and virulence poses a great challenge to public health.
Mahan Ghafari, Qihan Liu, Arushi Dhillon, Aris Katzourakis, Daniel B. Weissman   +4 more
doaj   +1 more source

A cohort study to define the age-specific incidence and risk factors of Shigella diarrhoeal infections in Vietnamese children: a study protocol. [PDF]

, 2014
BACKGROUND: Shigella spp. are one of the most common causes of paediatric dysentery globally, responsible for a substantial proportion of diarrhoeal disease morbidity and mortality, particularly in industrialising regions.
Simmons, Cameron, Corinne N Thompson, James I Campbell, Ha Thanh Tuyen, Nguyen Thi Thanh Nhan, Lu Lan Vi, Minh, Pham Van, Nguyen Vinh Van Chau, Stephen Baker, Ly, Tran Thi Thao, Chau, Nguyen Van Vinh, Le Thi Quynh Nhi, Thwaites, Guy, Nguyen Trong Hieu, Nguyen Thi Van Thuy, Tran Do Hoang Nhu, Thompson, Corinne N, Van Thuy, Nguyen Thi, Pham Van Minh, Tuyen, Ha Thanh, Duong, Vu Thuy, Katherine L Anders, Hieu, Nguyen Trong, Anders, Katherine L., Le Thi Phuong Tu, Guy Thwaites, Vi, Lu Lan, Anders, Katherine L, Cameron Simmons, Van Chau, Nguyen Vinh, Campbell, James I, Van Minh, Pham, Tran Thi Thao Ly, Campbell, James I., Nhi, Le Thi Quynh, Vu Thuy Duong, Tu, Le Thi Phuong, Nhu, Tran Do Hoang, Nhan, Nguyen Thi Thanh, Baker, Stephen   +39 more
core   +2 more sources

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Two Years of SARS-CoV-2 Omicron Genomic Evolution in Brazil (2022–2024): Subvariant Tracking and Assessment of Regional Sequencing Efforts

Viruses
SARS-CoV-2, the virus responsible for COVID-19, has undergone significant genetic evolution since its emergence in 2019. This study examines the genomic diversity of SARS-CoV-2 in Brazil after the worst phase of the pandemic, the wider adoption of ...
Ueric José Borges de Souza, Fernando Rosado Spilki, Amilcar Tanuri, Paulo Michel Roehe, Fabrício Souza Campos   +4 more
doaj   +1 more source

Active disease surveillance in kangaroos utilising the commercial harvesting industry [PDF]

, 2011
The aim of this study was to develop a framework for disease surveillance in one of the Australia’s most abundant macropods using the kangaroo harvesting industry.
Potter, Abbey
core