Emerging Microbes and Infections, 2020 Emerging studies have indicated that some penaeidins restrict virus infection; however, the mechanism(s) involved are poorly understood. In the present study, we uncovered that penaeidins are a novel family of antiviral effectors against white spot ...
Bang Xiao +5 more
semanticscholar +1 more source
A Systemic Receptor Network Triggered by Human cytomegalovirus Entry [PDF]
, 2010 Virus entry is a multistep process that triggers a variety of cellular pathways interconnecting into a complex network, yet the molecular complexity of this network remains largely unsolved.
Li, Hong, Ren, Li, Wang, Anyou
core +4 more sources
Dissecting virus entry: replication-independent analysis of virus binding, internalization, and penetration using minimal complementation of β-galactosidase. [PDF]
PLoS ONE, 2014 Studies of viral entry into host cells often rely on the detection of post-entry parameters, such as viral replication or the expression of a reporter gene, rather than on measuring entry per se. The lack of assays to easily detect the different steps of
Christine Burkard +6 more
doaj +1 more source
Structural understanding of SARS-CoV-2 virus entry to host cells
Frontiers in Molecular Biosciences, 2023 Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a major global health concern associated with millions of fatalities worldwide.
Kim Le +7 more
doaj +1 more source
Understanding the process of envelope glycoprotein incorporation into virions in simian and feline immunodeficiency viruses [PDF]
, 2014 The lentiviral envelope glycoproteins (Env) mediate virus entry by interacting with specific receptors present at the cell surface, thereby determining viral tropism and pathogenesis.
Affranchino, Jose Luis +1 more
core +4 more sources
Humanized COVID‐19 decoy antibody effectively blocks viral entry and prevents SARS‐CoV‐2 infection
EMBO Molecular Medicine, 2020 To circumvent the devastating pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection, a humanized decoy antibody (ACE2‐Fc fusion protein) was designed to target the interaction between viral spike protein and its ...
Kuo-Yen Huang +12 more
semanticscholar +1 more source
The Role of L-Selectin in HIV Infection
Frontiers in Microbiology, 2021 HIV envelope glycoprotein is the most heavily glycosylated viral protein complex identified with over 20 glycans on its surface. This glycan canopy is thought to primarily shield the virus from host immune recognition as glycans are poor immunogens in ...
Jason Segura +6 more
doaj +1 more source
TRPC1 participates in the HSV-1 infection process by facilitating viral entry
Science Advances, 2020 TRPC1 channel facilitates virus infection. Mammalian transient receptor potential (TRP) channels are major components of Ca2+ signaling pathways and control a diversity of physiological functions. Here, we report a specific role for TRPC1 in the entry of
DongXu He +8 more
semanticscholar +1 more source
Building a mechanistic mathematical model of hepatitis C virus entry.
PLoS Computational Biology, 2019 The mechanism by which hepatitis C virus (HCV) gains entry into cells is a complex one, involving a broad range of host proteins. Entry is a critical phase of the viral lifecycle, and a potential target for therapeutic or vaccine-mediated intervention ...
Mphatso Kalemera +3 more
doaj +1 more source
Therapeutic development targeting host heparan sulfate proteoglycan in SARS-CoV-2 infection
Frontiers in MedicineThe global pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to an urgent need for effective therapeutic options.
Qi Zhang +3 more
doaj +1 more source