Results 81 to 90 of about 1,846,216 (386)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

Cholesterol-rich lipid rafts mediate endocytosis as a common pathway for respiratory syncytial virus entry into different host cells

Microbiology Spectrum
The entry of respiratory syncytial virus (RSV) into host cells is a multifaceted process involving viral adsorption, interaction of viral glycoproteins with cellular receptors, and utilization of various invasion pathways. Despite these complexities, our
Anqi Zhou, Bao Xue, Jiayi Zhong, Junjun Liu, Ran Peng, Fan Wang, Yuan Zhou, Jielin Tang, Qi Yang, Xinwen Chen   +9 more
doaj   +1 more source

Quantitative membrane proteomics reveals a role for tetraspanin enriched microdomains during entry of human cytomegalovirus. [PDF]

PLoS ONE, 2017
Human cytomegalovirus (HCMV) depends on and modulates multiple host cell membrane proteins during each stage of the viral life cycle. To gain a global view of the impact of HCMV-infection on membrane proteins, we analyzed HCMV-induced changes in the ...
Kasinath Viswanathan, Marieke C Verweij, Nessy John, Daniel Malouli, Klaus Früh   +4 more
doaj   +1 more source

SARS-CoV-2 Entry Genes Are Most Highly Expressed in Nasal Goblet and Ciliated Cells within Human Airways [PDF]

Nature Medicine, 2020
We investigated SARS-CoV-2 potential tropism by surveying expression of viral entry-associated genes in single-cell RNA-sequencing data from multiple tissues from healthy human donors. We co-detected these transcripts in specific respiratory, corneal and
W. Sungnak, N. Huang, C. Bécavin, M. Berg, R. Queen, Monika Litviňuková, Carlos Talavera-López, H. Maatz, D. Reichart, F. Sampaziotis, Kaylee B. Worlock, Masahiro Yoshida, Josephine L. Barnes, Nicholas E. Pascal Alvis Joseph Tushar J. Thu Elizabeth Oli Banovich Barbry Brazma Collin Desai Duong Eickelbe, N. Banovich, P. Barbry, A. Brazma, J. Collin, T. Desai, T. Duong, O. Eickelberg, C. Falk, M. Farzan, I. Glass, Ravindra K. Gupta, M. Haniffa, P. Horváth, N. Hubner, Deborah T. Hung, N. Kaminski, M. Krasnow, J. Kropski, Malte Kuhnemund, M. Lako, Haeock Lee, S. Leroy, Sten Linnarson, J. Lundeberg, K. Meyer, Zhichao Miao, A. Misharin, M. Nawijn, M. Nikolić, M. Noseda, J. Ordovas-Montañes, G. Oudit, D. Pe’er, J. Powell, S. Quake, J. Rajagopal, P. R. Tata, E. Rawlins, A. Regev, P. Reyfman, O. Rozenblatt-Rosen, K. Saeb‐Parsy, C. Samakovlis, H. Schiller, J. Schultze, M. Seibold, C. Seidman, J. Seidman, A. Shalek, D. Shepherd, J. Spence, A. Spira, Xin Sun, S. Teichmann, Fabian J Theis, Alexander M. Tsankov, L. Vallier, M. van den Berge, J. Whitsett, R. Xavier, Yan Xu, L. Zaragosi, Darin Zerti, Hongbo Zhang, Kun Zhang, M. Rojas, Francisco Figueiredo   +80 more
semanticscholar   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Persistent hepatitis C virus infection in vitro: coevolution of virus and host. [PDF]

, 2006
The virological and cellular consequences of persistent hepatitis C virus (HCV) infection have been elusive due to the absence of the requisite experimental systems.
Cheng, Guofeng, Chisari, Francis V, Chung, Josan, Gastaminza, Pablo, Isogawa, Masanori, McKeating, Jane A, Stamataki, Zania, Zhong, Jin   +7 more
core   +3 more sources

Live cell imaging of viral entry

Current Opinion in Virology, 2013
Viral entry encompasses the initial steps of infection starting from virion host cell attachment to viral genome release. Given the dynamic interactions between the virus and the host, many questions related to viral entry can be directly addressed by live cell imaging.
Sun, Eileen, He, Jiang, Zhuang, Xiaowei
openaire   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Elite suppressor-derived HIV-1 envelope glycoproteins exhibit reduced entry efficiency and kinetics. [PDF]

PLoS Pathogens, 2009
Elite suppressors (ES) are a rare subset of HIV-1-infected individuals who are able to maintain HIV-1 viral loads below the limit of detection by ultra-sensitive clinical assays in the absence of antiretroviral therapy.
Kara G Lassen, Michael A Lobritz, Justin R Bailey, Samantha Johnston, Sandra Nguyen, Benhur Lee, Tom Chou, Robert F Siliciano, Martin Markowitz, Eric J Arts   +9 more
doaj   +1 more source