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Role of Viral Envelope Proteins in Determining Susceptibility of Viruses to IFITM Proteins [PDF]

Viruses
Interferon-induced transmembrane proteins (IFITMs) are a family of proteins which inhibit infections of various enveloped viruses. While their general mechanism of inhibition seems to be non-specific, involving the tightening of membrane structures to ...
Thomas Marceau, Martine Braibant
doaj   +5 more sources

MARCH8 Targets Cytoplasmic Lysine Residues of Various Viral Envelope Glycoproteins

Microbiology Spectrum, 2022
The host transmembrane protein MARCH8 is a RING finger E3 ubiquitin ligase that downregulates various host transmembrane proteins, such as MHC-II. We have recently reported that MARCH8 expression in virus-producing cells impairs viral infectivity by ...
Yanzhao Zhang, Seiya Ozono, Takuya Tada, Minoru Tobiume, Masanori Kameoka, Satoshi Kishigami, Hideaki Fujita, Kenzo Tokunaga   +7 more
doaj   +2 more sources

Viral envelope proteins fused to multiple distinct fluorescent reporters to probe receptor binding

Protein Science, 2023
AbstractEnveloped viruses carry one or multiple proteins with receptor binding functionalities. Functional receptors can either be glycans, proteinaceous or both, recombinant protein approaches are instrumental to gain more insight into these binding properties.
Tomris I, van der Woude R, de Paiva Droes Rocha R, Torrents de la Peña A, Ward AB, de Vries RP.   +5 more
europepmc   +5 more sources

A Deacetylase CqSIRT1 Promotes WSSV Infection by Binding to Viral Envelope Proteins in Cherax quadricarinatus [PDF]

Viruses, 2022
Sirtuin 1 (SIRT1), a member of the class III lysine deacetylases, exhibits powerful functional diversity in physiological processes and disease occurrences. However, the potential molecular mechanism underlying the role of SIRT1 during viral infection in
Shucheng Zheng, Fanjuan Meng, Dongli Li, Lingke Liu, Di Ge, Qing Wang, Haipeng Liu   +6 more
doaj   +2 more sources

Super-resolution microscopy reveals specific recruitment of HIV-1 envelope proteins to viral assembly sites dependent on the envelope C-terminal tail [PDF]

PLoS Pathogens, 2013
The inner structural Gag proteins and the envelope (Env) glycoproteins of human immunodeficiency virus (HIV-1) traffic independently to the plasma membrane, where they assemble the nascent virion. HIV-1 carries a relatively low number of glycoproteins in
Heilemann, Mike, Kräusslich, Hans-Georg, Malkusch, Sebastian, Muranyi, Walter, Müller, Barbara   +4 more
core   +12 more sources

B Cell Receptor's function in virus entry: Anti-SARS-CoV-2 B cell receptors can mediate viral entry in an ACE2-independent mechanism. [PDF]

PLoS Pathogens
B cells play a crucial role in humoral immunity, acting as sentinels against viral infections by using their B cell receptors (BCRs) to recognize viral proteins.
Rene Larios, Md Belal Hossain, Rebecca Brown, Arjit Vijey Jeyachandran, Angel Elma Abu, Anne Kathrin Zaiss, Christina M Ramirez, Masakazu Kamata, Steve Cole, Ting-Ting Wu, Kenneth Dorshkind, Vaithilingaraja Arumugaswami, Kouki Morizono   +12 more
doaj   +2 more sources

Mammalian cell surface display for monoclonal antibody-based FACS selection of viral envelope proteins. [PDF]

MAbs, 2017
The elicitation of broadly and efficiently neutralizing antibodies in humans by active immunization is still a major obstacle in the development of vaccines against pathogens such as the human immunodeficiency virus (HIV), influenza virus, hepatitis C virus or cytomegalovirus.
Bruun TH, Grassmann V, Zimmer B, Asbach B, Peterhoff D, Kliche A, Wagner R.   +6 more
europepmc   +4 more sources

The human E3 ligase RNF185 is a regulator of the SARS-CoV-2 envelope protein

iScience, 2023
Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) hijacks multiple human proteins during infection and viral replication. To examine whether any viral proteins employ human E3 ubiquitin ligases, we evaluated the stability of SARS-CoV ...
Charles Zou, Hojong Yoon, Paul M.C. Park, J.J. Patten, Jesse Pellman, Jeannie Carreiro, Jonathan M. Tsai, Yen-Der Li, Shourya S. Roy Burman, Katherine A. Donovan, Jessica Gasser, Adam S. Sperling, Radosław P. Nowak, Eric S. Fischer, Robert A. Davey, Benjamin L. Ebert, Mikołaj Słabicki   +16 more
doaj   +1 more source

Host antiviral factors hijack furin to block SARS-CoV-2, ebola virus, and HIV-1 glycoproteins cleavage

Emerging Microbes and Infections, 2023
Viral envelope glycoproteins are crucial for viral infections. In the process of enveloped viruses budding and release from the producer cells, viral envelope glycoproteins are presented on the viral membrane surface as spikes, promoting the virus's next-
Changqing Yu, Guosheng Wang, Qiang Liu, Jingbo Zhai, Mengzhou Xue, Qiang Li, Yuanhua Xian, Chunfu Zheng   +7 more
doaj   +1 more source

Nucleocapsid-Independent Specific Viral RNA Packaging via Viral Envelope Protein and Viral RNA Signal [PDF]

Journal of Virology, 2003
ABSTRACT For any of the enveloped RNA viruses studied to date, recognition of a specific RNA packaging signal by the virus's nucleocapsid (N) protein is the first step described in the process of viral RNA packaging. In the murine coronavirus a selective interaction between the viral transmembrane envelope protein M and the viral
Narayanan, K, Chen, CJ, Maeda, J, Makino, S   +3 more
openaire   +2 more sources