Results 11 to 20 of about 205,399 (342)
Structure and Role of O-Linked Glycans in Viral Envelope Proteins [PDF]
Annual Review of Virology, 2023 N- and O-glycans are both important constituents of viral envelope glycoproteins. O-linked glycosylation can be initiated by any of 20 different human polypeptide O-acetylgalactosaminyl transferases, resulting in an important functional O-glycan heterogeneity.
Sigvard Olofsson +3 more
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Viral and Host Factors Regulating HIV-1 Envelope Protein Trafficking and Particle Incorporation [PDF]
Viruses, 2022 The HIV-1 envelope glycoprotein (Env) is an essential structural component of the virus, serving as the receptor-binding protein and principal neutralizing determinant. Env trimers are incorporated into developing particles at the plasma membrane of infected cells. Incorporation of HIV-1 Env into particles in T cells and macrophages is regulated by the
Boris Anokhin, Paul Spearman
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Inhibition of Flaviviruses by Targeting a Conserved Pocket on the Viral Envelope Protein [PDF]
Cell Chemical Biology, 2018 Viral envelope proteins are required for productive viral entry and initiation of infection. Although the humoral immune system provides ample evidence for targeting envelope proteins as an antiviral strategy, there are few pharmacological interventions that have this mode of action.
Mélissanne de Wispelaere +15 more
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Flavivirus Envelope Protein Glycosylation: Impacts on Viral Infection and Pathogenesis
Journal of Virology, 2020 Flaviviruses encode one, two, or no N -linked glycosylation sites on their envelope proteins. Glycosylation can impact virus interactions with cell surface attachment factors and also may impact virion stability and virus replication.
Derek L. Carbaugh, Helen M. Lazear
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Emerging Microbes and Infections, 2023 Viral envelope glycoproteins are crucial for viral infections. In the process of enveloped viruses budding and release from the producer cells, viral envelope glycoproteins are presented on the viral membrane surface as spikes, promoting the virus's next-
Changqing Yu +7 more
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Nucleocapsid-Independent Specific Viral RNA Packaging via Viral Envelope Protein and Viral RNA Signal [PDF]
Journal of Virology, 2003 ABSTRACT For any of the enveloped RNA viruses studied to date, recognition of a specific RNA packaging signal by the virus's nucleocapsid (N) protein is the first step described in the process of viral RNA packaging. In the murine coronavirus a selective interaction between the viral transmembrane envelope protein M and the viral
Narayanan, K +3 more
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Embedding a membrane protein into an enveloped artificial viral replica
RSC Chemical Biology, 2022 We demonstrate the embedding membrane protein, Cx43, on the enveloped artificial viral capsid using a cell-free expression system. The embedding of Cx43 on the envelope was evaluated by detection with anti-Cx43 antibody using FCS and TEM.
Hiroto Furukawa +4 more
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Yeast two hybrid analyses reveal novel binary interactions between human cytomegalovirus-encoded virion proteins. [PDF]
PLoS ONE, 2011 Human cytomegalovirus (HCMV) is the largest human herpesvirus and its virion contains many viral encoded proteins found in the capsid, tegument, and envelope.
Aaron To +6 more
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The structure of a prokaryotic viral envelope protein expands the landscape of membrane fusion proteins [PDF]
Nature Communications, 2019 AbstractLipid membrane fusion is an essential function in many biological processes. Detailed mechanisms of membrane fusion and the protein structures involved have been mainly studied in eukaryotic systems, whereas very little is known about membrane fusion in prokaryotes.
Kamel El Omari +17 more
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Cell type-specific delivery by modular envelope design
Nature Communications, 2023 The delivery of genetic cargo remains one of the largest obstacles to the successful translation of experimental therapies, in large part due to the absence of targetable delivery vectors.
Daniel Strebinger +5 more
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