ViralFP: A Web Application of Viral Fusion Proteins [PDF]
Frontiers in Medical Technology, 2021 Viral fusion proteins are attached to the membrane of enveloped viruses (a group that includes Coronaviruses, Dengue, HIV and Influenza) and catalyze fusion between the viral and host membranes, enabling the virus to insert its genetic material into the ...
Pedro Moreira +5 more
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Transmembrane Domains of Highly Pathogenic Viral Fusion Proteins Exhibit Trimeric Association
mSphere, 2018 Enveloped viruses require viral fusion proteins to promote fusion of the viral envelope with a target cell membrane. To drive fusion, these proteins undergo large conformational changes that must occur at the right place and at the right time ...
Stacy R. Webb +3 more
doaj +2 more sources
Viral fusion proteins of classes II and III recognize and reorganize complex biological membranes [PDF]
Communications BiologyViral infection requires stable binding of viral fusion proteins to host membranes, which contain hundreds of lipid species. The mechanisms by which fusion proteins utilize specific host lipids to drive virus–host membrane fusion remains elusive.
Chetan S. Poojari +2 more
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Structure-Guided Design of Peptide Inhibitors Targeting Class I Viral Fusion Proteins [PDF]
PathogensViral fusion proteins are indispensable mediators of viral entry that orchestrate the fusion of viral and host membranes, making them primary targets for antiviral interventions.
Narendra Kumar Gonepudi +4 more
doaj +2 more sources
ViralFP: A webserver of viral fusion proteins
, 2021 Viral fusion proteins are attached to the membrane of enveloped viruses (a group that includes Coronaviruses, Dengue, HIV and Influenza) and catalyze fusion between the viral and host membranes, enabling the virus to insert its genetic material into the host cell.
Moreira P +5 more
europepmc +3 more sources
Transient Transfection-based Fusion Assay for Viral Proteins
Bio-Protocol, 2017 Membrane fusion is vital for entry of enveloped viruses into host cells as well as for direct viral cell-to-cell spread. To understand the fusion mechanism in more detail, we use an infection free system whereby fusion can be induced by a minimal set of ...
Melina Vallbracht +3 more
doaj +4 more sources
B Cell Receptor's function in virus entry: Anti-SARS-CoV-2 B cell receptors can mediate viral entry in an ACE2-independent mechanism. [PDF]
PLoS PathogensB cells play a crucial role in humoral immunity, acting as sentinels against viral infections by using their B cell receptors (BCRs) to recognize viral proteins.
Rene Larios +12 more
doaj +2 more sources
Viral membrane fusion: is glycoprotein G of rhabdoviruses a representative of a new class of viral fusion proteins? [PDF]
Brazilian Journal of Medical and Biological Research, 2005 Enveloped viruses always gain entry into the cytoplasm by fusion of their lipid envelope with a cell membrane. Some enveloped viruses fuse directly with the host cell plasma membrane after virus binding to the cell receptor. Other enveloped viruses enter
A.T. Da Poian +2 more
doaj +5 more sources
Shielding and activation of a viral membrane fusion protein [PDF]
Nature Communications, 2018 Viral fusion proteins undergo extensive conformational changes during entry but intermediate conformations often remain unknown. Here, the authors show how Gn of Rift Valley fever virus fusion protein shields hydrophobic fusion loops of Gc and how these ...
Steinar Halldorsson +5 more
doaj +5 more sources
Identification and Characteristics of Fusion Peptides Derived From Enveloped Viruses
Frontiers in Chemistry, 2021 Membrane fusion events allow enveloped viruses to enter and infect cells. The study of these processes has led to the identification of a number of proteins that mediate this process. These proteins are classified according to their structure, which vary
Camille Lozada +5 more
doaj +1 more source