ViralFP: A Web Application of Viral Fusion Proteins [PDF]
Frontiers in Medical Technology, 2021 Viral fusion proteins are attached to the membrane of enveloped viruses (a group that includes Coronaviruses, Dengue, HIV and Influenza) and catalyze fusion between the viral and host membranes, enabling the virus to insert its genetic material into the ...
Pedro Moreira +5 more
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Viral membrane fusion: is glycoprotein G of rhabdoviruses a representative of a new class of viral fusion proteins? [PDF]
Brazilian Journal of Medical and Biological Research, 2005 Enveloped viruses always gain entry into the cytoplasm by fusion of their lipid envelope with a cell membrane. Some enveloped viruses fuse directly with the host cell plasma membrane after virus binding to the cell receptor. Other enveloped viruses enter
A.T. Da Poian +2 more
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Transmembrane Domains of Highly Pathogenic Viral Fusion Proteins Exhibit Trimeric Association
mSphere, 2018 Enveloped viruses require viral fusion proteins to promote fusion of the viral envelope with a target cell membrane. To drive fusion, these proteins undergo large conformational changes that must occur at the right place and at the right time ...
Stacy R. Webb +3 more
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Surfactant Proteins A and D: Trimerized Innate Immunity Proteins with an Affinity for Viral Fusion Proteins. [PDF]
J Innate Immun, 2019 Innate recognition of viruses is an essential part of the immune response to viral pathogens. This is integral to the maintenance of healthy lungs, which are free from infection and efficient at gaseous exchange. An important component of innate immunity
Watson A +4 more
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Viral fusion proteins of classes II and III recognize and reorganize complex biological membranes [PDF]
Communications BiologyViral infection requires stable binding of viral fusion proteins to host membranes, which contain hundreds of lipid species. The mechanisms by which fusion proteins utilize specific host lipids to drive virus–host membrane fusion remains elusive.
Chetan S. Poojari +2 more
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Proteomics Computational Analyses Suggest That the Envelope Glycoproteins of Segmented Jingmen Flavi-Like Viruses are Class II Viral Fusion Proteins (b-Penetrenes) with Mucin-Like Domains. [PDF]
Viruses, 2020 Jingmen viruses are newly described segmented flavi-like viruses that have a worldwide distribution in ticks and have been associated with febrile illnesses in humans.
Garry CE, Garry RF.
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De Novo Design of α-Helical Lipopeptides Targeting Viral Fusion Proteins: A Promising Strategy for Relatively Broad-Spectrum Antiviral Drug Discovery. [PDF]
J Med Chem, 2018 Class I enveloped viruses share similarities in their apparent use of a hexameric coiled-coil assembly to drive the merging of virus and host cell membranes.
Wang C +12 more
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Viruses, 2020 Protein-mediated membrane fusion is a highly regulated biological process essential for cellular and organismal functions and infection by enveloped viruses. During viral entry the membrane fusion reaction is catalyzed by specialized protein machinery on
Mark A. Benhaim, Kelly K. Lee
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Viral Membrane Fusion and the Transmembrane Domain
Viruses, 2020 Initiation of host cell infection by an enveloped virus requires a viral-to-host cell membrane fusion event. This event is mediated by at least one viral transmembrane glycoprotein, termed the fusion protein, which is a key therapeutic target.
Chelsea T. Barrett, Rebecca Ellis Dutch
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Structural and functional analysis of vaccinia viral fusion complex component protein A28 through NMR and molecular dynamic simulations. [PDF]
PLoS Pathogens, 2023 Host cell entry of vaccinia virus (a poxvirus) proceeds through multiple steps that involve many viral proteins to mediate cell infection. Upon binding to cells, vaccinia virus membrane fuses with host membranes via a viral entry fusion protein complex ...
Chi-Fei Kao +4 more
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