Shielding and activation of a viral membrane fusion protein [PDF]
Nature Communications, 2018 Viral fusion proteins undergo extensive conformational changes during entry but intermediate conformations often remain unknown. Here, the authors show how Gn of Rift Valley fever virus fusion protein shields hydrophobic fusion loops of Gc and how these ...
Steinar Halldorsson +5 more
doaj +6 more sources
Rubella Virus: First Calcium-Requiring Viral Fusion Protein [PDF]
PLoS Pathogens, 2014 Rubella virus (RuV) infection of pregnant women can cause fetal death, miscarriage, or severe fetal malformations, and remains a significant health problem in much of the underdeveloped world.
Mathieu Dubé +2 more
semanticscholar +7 more sources
ViralFP: A webserver of viral fusion proteins
, 2021 Viral fusion proteins are attached to the membrane of enveloped viruses (a group that includes Coronaviruses, Dengue, HIV and Influenza) and catalyze fusion between the viral and host membranes, enabling the virus to insert its genetic material into the host cell.
Moreira P +5 more
europepmc +5 more sources
Viral Membrane Fusion: A Dance Between Proteins and Lipids
Annual Review of Virology, 2023 There are at least 21 families of enveloped viruses that infect mammals, and many contain members of high concern for global human health. All enveloped viruses have a dedicated fusion protein or fusion complex that enacts the critical genome-releasing ...
Judith M. White +3 more
semanticscholar +3 more sources
Peptides from conserved regions of paramyxovirus fusion (F) proteins are potent inhibitors of viral fusion. [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 1996 The synthetic peptides DP-107 and DP-178 (T-20), derived from separate domains within the human immunodeficiency virus type 1 (HIV-1) transmembrane (TM) protein, gp4l, are stable and potent inhibitors of HIV-1 infection and fusion.
D.M. Lambert +9 more
openalex +2 more sources
Viral Membrane Fusion Proteins and RNA Sorting Mechanisms for the Molecular Delivery by Exosomes [PDF]
Cells, 2021 The advancement of precision medicine critically depends on the robustness and specificity of the carriers used for the targeted delivery of effector molecules in the human body.
I. Zubarev +8 more
semanticscholar +6 more sources
Lipids as modulators of membrane fusion mediated by viral fusion proteins [PDF]
European Biophysics Journal, 2007 Enveloped viruses infect host cells by fusion of viral and target membranes. This fusion event is triggered by specific glycoproteins in the viral envelope.
Élodie Teissier, E. Pécheur
semanticscholar +5 more sources
Transient Transfection-based Fusion Assay for Viral Proteins [PDF]
Bio-Protocol, 2017 Membrane fusion is vital for entry of enveloped viruses into host cells as well as for direct viral cell-to-cell spread. To understand the fusion mechanism in more detail, we use an infection free system whereby fusion can be induced by a minimal set of ...
Melina Vallbracht +3 more
doaj +4 more sources
The structure of a prokaryotic viral envelope protein expands the landscape of membrane fusion proteins [PDF]
Nature Communications, 2019 Lipid membrane fusion is an essential function in many biological processes. Detailed mechanisms of membrane fusion and the protein structures involved have been mainly studied in eukaryotic systems, whereas very little is known about membrane fusion in ...
K. el Omari +17 more
semanticscholar +5 more sources
Macrocyclic peptide inhibitors of viral fusion proteins
Pandemic outbreaks of viruses present a significant global challenge, necessitating continuous updates to vaccines and exploration of new antiviral drugs.
Vito Thijssen
semanticscholar +3 more sources