Results 11 to 20 of about 216,108 (259)
Viruses, 2023 The fusion of viral and cell membranes is one of the basic processes in the life cycles of viruses. A number of enveloped viruses confer fusion of the viral envelope and the cell membrane using surface viral fusion proteins.
Sophia S. Borisevich +4 more
doaj +1 more source
Class III Viral Membrane Fusion Proteins [PDF]
Current Opinion in Structural Biology, 2009 Accumulating structural studies of viral fusion glycoproteins have revealed unanticipated structural relationships between unrelated virus families and allowed the grouping of these membrane fusogens into three distinct classes. Here we review the newly identified group of class III viral fusion proteins, whose members include fusion proteins from ...
Marija, Backovic, Theodore S, Jardetzky
openaire +3 more sources
Viral Membrane Fusion and the Transmembrane Domain
Viruses, 2020 Initiation of host cell infection by an enveloped virus requires a viral-to-host cell membrane fusion event. This event is mediated by at least one viral transmembrane glycoprotein, termed the fusion protein, which is a key therapeutic target.
Chelsea T. Barrett, Rebecca Ellis Dutch
doaj +1 more source
Viruses, 2020 Protein-mediated membrane fusion is a highly regulated biological process essential for cellular and organismal functions and infection by enveloped viruses. During viral entry the membrane fusion reaction is catalyzed by specialized protein machinery on
Mark A. Benhaim, Kelly K. Lee
doaj +1 more source
New insights into the role of endosomal proteins for African swine fever virus infection.
PLoS Pathogens, 2022 African swine fever virus (ASFV) infectious cycle starts with the viral adsorption and entry into the host cell. Then, the virus is internalized via clathrin/dynamin mediated endocytosis and macropinocytosis.
Miguel Ángel Cuesta-Geijo +11 more
doaj +1 more source
Lipids as modulators of membrane fusion mediated by viral fusion proteins [PDF]
European Biophysics Journal, 2007 Enveloped viruses infect host cells by fusion of viral and target membranes. This fusion event is triggered by specific glycoproteins in the viral envelope. Fusion glycoproteins belong to either class I, class II or the newly described third class, depending upon their arrangement at the surface of the virion, their tri-dimensional structure and the ...
Teissier, E., Pecheur, Ei
openaire +3 more sources
A Frame-by-Frame Glance at Membrane Fusion Mechanisms: From Viral Infections to Fertilization
Biomolecules, 2023 Viral entry and fertilization are distinct biological processes that share a common mechanism: membrane fusion. In viral entry, enveloped viruses attach to the host cell membrane, triggering a series of conformational changes in the viral fusion proteins.
Farshad C. Azimi +5 more
doaj +1 more source
A fusion-inhibiting peptide against Rift Valley fever virus inhibits multiple, diverse viruses. [PDF]
PLoS Neglected Tropical Diseases, 2013 For enveloped viruses, fusion of the viral envelope with a cellular membrane is critical for a productive infection to occur. This fusion process is mediated by at least three classes of fusion proteins (Class I, II, and III) based on the protein ...
Jeffrey W Koehler +11 more
doaj +1 more source
Viruses, 2022 The membrane surface of enveloped viruses contains dedicated proteins enabling the fusion of the viral with the host cell membrane. Working with these proteins is almost always challenging because they are membrane-embedded and naturally metastable ...
Henriette Ebel +2 more
doaj +1 more source
PLoS Computational Biology, 2022 Antibody epitope mapping of viral proteins plays a vital role in understanding immune system mechanisms of protection. In the case of class I viral fusion proteins, recent advances in cryo-electron microscopy and protein stabilization techniques have ...
Marion F S Fischer +2 more
doaj +1 more source