Results 11 to 20 of about 319,921 (262)
ViralFP: A webserver of viral fusion proteins [PDF]
arXiv, 2021 Viral fusion proteins are attached to the membrane of enveloped viruses (a group that includes Coronaviruses, Dengue, HIV and Influenza) and catalyze fusion between the viral and host membranes, enabling the virus to insert its genetic material into the host cell.
Moreira P +5 more
europepmc +6 more sources
Viral membrane fusion: is glycoprotein G of rhabdoviruses a representative of a new class of viral fusion proteins? [PDF]
Brazilian Journal of Medical and Biological Research, 2005 Enveloped viruses always gain entry into the cytoplasm by fusion of their lipid envelope with a cell membrane. Some enveloped viruses fuse directly with the host cell plasma membrane after virus binding to the cell receptor. Other enveloped viruses enter the cells by the endocytic pathway, and fusion depends on the acidification of the endosomal ...
Da Poian, A.T. +2 more
doaj +9 more sources
Viral fusion proteins of classes II and III recognize and reorganize complex biological membranes. [PDF]
Commun BiolViral infection requires stable binding of viral fusion proteins to host membranes, which contain hundreds of lipid species. The mechanisms by which fusion proteins utilize specific host lipids to drive virus–host membrane fusion remains elusive.
Poojari CS, Bommer T, Hub JS.
europepmc +3 more sources
Structural and functional analysis of vaccinia viral fusion complex component protein A28 through NMR and molecular dynamic simulations. [PDF]
PLoS Pathogens, 2023 Host cell entry of vaccinia virus (a poxvirus) proceeds through multiple steps that involve many viral proteins to mediate cell infection. Upon binding to cells, vaccinia virus membrane fuses with host membranes via a viral entry fusion protein complex ...
Chi-Fei Kao +4 more
doaj +2 more sources
Transient Transfection-based Fusion Assay for Viral Proteins [PDF]
BIO-PROTOCOL, 2017 Membrane fusion is vital for entry of enveloped viruses into host cells as well as for direct viral cell-to-cell spread. To understand the fusion mechanism in more detail, we use an infection free system whereby fusion can be induced by a minimal set of the alphaherpesvirus pseudorabies virus (PrV) glycoproteins gB, gH and gL.
Christina Schröter +3 more
openaire +5 more sources
Shielding and activation of a viral membrane fusion protein [PDF]
Nature Communications, 2018 AbstractEntry of enveloped viruses relies on insertion of hydrophobic residues of the viral fusion protein into the host cell membrane. However, the intermediate conformations during fusion remain unknown. Here, we address the fusion mechanism of Rift Valley fever virus.
Halldorsson, S +5 more
openaire +5 more sources
Class II Membrane Fusion Proteins in Viral and Cellular Fusion Events [PDF]
Biophysical Journal, 2013 Class II proteins are viral membrane fusogenic molecules folded essentially as beta-sheet and having an internal fusion peptide. In particular, they lack the characteristic central alpha-helical coiled coil present in the post-fusion conformation of all other viral fusion proteins. The regular, symmetric enveloped viruses that have been studied so far,
Benjamin Podbilewicz +3 more
openaire +4 more sources
Rubella Virus: First Calcium-Requiring Viral Fusion Protein [PDF]
PLoS Pathogens, 2014 Rubella virus (RuV) infection of pregnant women can cause fetal death, miscarriage, or severe fetal malformations, and remains a significant health problem in much of the underdeveloped world. RuV is a small enveloped RNA virus that infects target cells by receptor-mediated endocytosis and low pH-dependent membrane fusion.
Félix A. Rey +2 more
openaire +6 more sources
Mechanism of Membrane Fusion by Viral Envelope Proteins
, 2005 Enveloped viruses enter cells by fusing their lipid bilayer membrane with a cellular membrane. Most viral fusion proteins require priming by proteolytic processing, either of the fusion protein itself or of an accompanying protein. The priming step, which often occurs during transport of the fusion protein to the cell surface but may also occur ...
Stephen C. Harrison
openaire +4 more sources
Peptide inhibitors of dengue virus and West Nile virus infectivity [PDF]
Virology Journal, 2005 Viral fusion proteins mediate cell entry by undergoing a series of conformational changes that result in virion-target cell membrane fusion. Class I viral fusion proteins, such as those encoded by influenza virus and human immunodeficiency virus (HIV ...
Garry, Robert F +2 more
core +5 more sources