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The Many Mechanisms of Viral Membrane Fusion Proteins [PDF]
Current Topics in Microbiology and Immunology, 2005 Every enveloped virus fuses its membrane with a host cell membrane, thereby releasing its genome into the cytoplasm and initiating the viral replication cycle. In each case, one or a small set of viral surface transmembrane glycoproteins mediates fusion.
Laurie J. Earp +3 more
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Identification of an N-Terminal Trimeric Coiled-Coil Core within Arenavirus Glycoprotein 2 Permits Assignment to Class I Viral Fusion Proteins [PDF]
Journal of Virology, 2006 Bruno Eschli +5 more
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Journal of Molecular Biology, 1999 Crystallographic studies have shown that the coiled-coil motif occurs in several viral membrane-fusion proteins, including HIV-1 gp41 and influenza virus hemagglutinin. Here, the LearnCoil-VMF program was designed as a specialized program for identifying
Mona Singh, Bonnie Berger, Peter S. Kim
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Common principles and intermediates of viral protein-mediated fusion: the HIV-1 paradigm [PDF]
Retrovirology, 2008 Enveloped viruses encode specialized fusion proteins which promote the merger of viral and cell membranes, permitting the cytosolic release of the viral cores.
Melikyan Gregory B
doaj +3 more sources
Journal of General Virology, 1995 Introduction. Entry of enveloped viruses into host cells requires binding of the virus to one or more receptors present at the host cell surface followed by fusion of the viral envelope with a cellular membrane.
Y. Gaudin, R. Ruigrok, J. Brunner
semanticscholar +3 more sources
Structural characterization of viral fusion proteins [PDF]
Current Biology, 1995 Infection by enveloped viruses is initiated by the fusion of viral and cellular membranes. In many cases, the viral membrane proteins that mediate fusion must undergo conformational changes to become active. Influenza hemagglutinin, for example, is activated by a dramatic conformational rearrangement, triggered by the low pH of the intracellular ...
F. Hughson
semanticscholar +4 more sources
Class II Membrane Fusion Proteins in Viral and Cellular Fusion Events [PDF]
Biophysical Journal, 2013 Class II proteins are viral membrane fusogenic molecules folded essentially as beta-sheet and having an internal fusion peptide. In particular, they lack the characteristic central alpha-helical coiled coil present in the post-fusion conformation of all other viral fusion proteins. The regular, symmetric enveloped viruses that have been studied so far,
F.A. Rey +3 more
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Viral fusion proteins: multiple regions contribute to membrane fusion.
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2003 In recent years, the simple picture of a viral fusion protein interacting with the cell and/or viral membranes by means of only two localized segments (i.e. the fusion peptide and the transmembrane domain) has given way to a more complex picture in which multiple regions from the viral proteins interact with membranes.
S. Peisajovich, Y. Shai
semanticscholar +4 more sources
Ezrin interacts with the SARS coronavirus spike protein and restrains infection at the entry stage [PDF]
, 2012 © 2012 Millet et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
A Chen +79 more
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Identification and Characteristics of Fusion Peptides Derived From Enveloped Viruses
Frontiers in Chemistry, 2021 Membrane fusion events allow enveloped viruses to enter and infect cells. The study of these processes has led to the identification of a number of proteins that mediate this process. These proteins are classified according to their structure, which vary
Camille Lozada +5 more
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