Results 21 to 30 of about 123,823 (255)

Transmembrane Domains of Highly Pathogenic Viral Fusion Proteins Exhibit Trimeric Association In Vitro

mSphere, 2018
Enveloped viruses require viral fusion proteins to promote fusion of the viral envelope with a target cell membrane. To drive fusion, these proteins undergo large conformational changes that must occur at the right place and at the right time ...
Stacy R. Webb, Stacy E. Smith, Michael G. Fried, Rebecca Ellis Dutch   +3 more
doaj   +1 more source

Inhibition of the Hantavirus Fusion Process by Predicted Domain III and Stem Peptides from Glycoprotein Gc. [PDF]

PLoS Neglected Tropical Diseases, 2016
Hantaviruses can cause hantavirus pulmonary syndrome or hemorrhagic fever with renal syndrome in humans. To enter cells, hantaviruses fuse their envelope membrane with host cell membranes.
Gonzalo P Barriga, Fernando Villalón-Letelier, Chantal L Márquez, Eduardo A Bignon, Rodrigo Acuña, Breyan H Ross, Octavio Monasterio, Gonzalo A Mardones, Simon E Vidal, Nicole D Tischler   +9 more
doaj   +1 more source

Structural and functional analysis of vaccinia viral fusion complex component protein A28 through NMR and molecular dynamic simulations.

PLoS Pathogens, 2023
Host cell entry of vaccinia virus (a poxvirus) proceeds through multiple steps that involve many viral proteins to mediate cell infection. Upon binding to cells, vaccinia virus membrane fuses with host membranes via a viral entry fusion protein complex ...
Chi-Fei Kao, Min-Hsin Tsai, Kathleen Joyce Carillo, Der-Lii Tzou, Wen Chang   +4 more
doaj   +1 more source

SARS-CoV-2 Fusion Peptide Conjugated to a Tetravalent Dendrimer Selectively Inhibits Viral Infection

Pharmaceutics, 2023
Fusion is a key event for enveloped viruses, through which viral and cell membranes come into close contact. This event is mediated by viral fusion proteins, which are divided into three structural and functional classes.
Carla Zannella, Annalisa Chianese, Alessandra Monti, Rosa Giugliano, Maria Vittoria Morone, Francesco Secci, Giuseppina Sanna, Aldo Manzin, Anna De Filippis, Nunzianna Doti, Massimiliano Galdiero   +10 more
doaj   +1 more source

IFITM proteins restrict viral membrane hemifusion.

PLoS Pathogens, 2013
The interferon-inducible transmembrane (IFITM) protein family represents a new class of cellular restriction factors that block early stages of viral replication; the underlying mechanism is currently not known.
Kun Li, Ruben M Markosyan, Yi-Min Zheng, Ottavia Golfetto, Brittani Bungart, Minghua Li, Shilei Ding, Yuxian He, Chen Liang, James C Lee, Enrico Gratton, Fredric S Cohen, Shan-Lu Liu   +12 more
doaj   +1 more source

A Bimolecular Multicellular Complementation System for the Detection of Syncytium Formation: A New Methodology for the Identification of Nipah Virus Entry Inhibitors

Viruses, 2019
Fusion of viral and cellular membranes is a key step during the viral life cycle. Enveloped viruses trigger this process by means of specialized viral proteins expressed on their surface, the so-called viral fusion proteins.
María J. García-Murria, Neus Expósito-Domínguez, Gerard Duart, Ismael Mingarro, Luis Martinez-Gil   +4 more
doaj   +1 more source

Advances in the design and development of oncolytic measles viruses. [PDF]

, 2015
A successful oncolytic virus is one that selectively propagates and destroys cancerous tissue without causing excessive damage to the normal surrounding tissue. Oncolytic measles virus (MV) is one such virus that exhibits this characteristic and thus has
Hutzen, Brian, Raffel, Corey, Studebaker, Adam W   +2 more
core   +1 more source

Influence of N-glycosylation on Expression and Function of Pseudorabies Virus Glycoprotein gB

Pathogens, 2021
Envelope glycoprotein (g)B is conserved throughout the Herpesviridae and mediates fusion of the viral envelope with cellular membranes for infectious entry and spread.
Melina Vallbracht, Barbara G. Klupp, Thomas C. Mettenleiter   +2 more
doaj   +1 more source

Conformational reorganization of the SARS coronavirus spike following receptor binding: implications for membrane fusion. [PDF]

PLoS ONE, 2007
The SARS coronavirus (SARS-CoV) spike is the largest known viral spike molecule, and shares a similar function with all class 1 viral fusion proteins.
Daniel R Beniac, Shauna L deVarennes, Anton Andonov, Runtao He, Tim F Booth   +4 more
doaj   +1 more source

Interactions in vivo between the Vif protein of HIV-1 and the precursor (Pr55GAG) of the virion nucleocapsid proteins [PDF]

, 2009
The abnormality of viral core structure seen in vif-defective HIV-1 grown in PBMCs has suggested a role for Vif in viral morphogenesis. Using an in vivo mammalian two-hybrid assay, the interaction between Vif and the precursor (Pr55GAG) of the virion ...
A Harmache, A Mehle, AM Borman, AM Sheehy, AM Sheehy, B Liu, B Liu, B Mangeat, C Tian, DH Gabuzda, DH Gabuzda, Farhatullah Syed, H Ochman, H Zhang, HA Vasavada, I Sadowski, JH Simon, K Luo, K Stopak, L Baraz, L Fan, M Bouyac, M Bouyac, M Boyce, M Marin, MA Adekale, Malcolm A. McCrae, MS Oberste, N Madani, RA Fouchier, RC Desrosiers, RS Harris, S Cen, S Erickson-Viitanen, S Hoglund, SG Conticello, SK Arya, TH Lee, X Yu, Y Gluzman, Y Imai, Y Yu, YH Zheng   +42 more
core   +1 more source