Results 21 to 30 of about 319,921 (262)

Receptor-Activated Binding of Viral Fusion Proteins to Target Membranes

, 2003
This chapter describes three assays to monitor receptor-induced association of the envelope glycoprotein (EnvA) of avian sarcoma/leukosis virus (ASLV) with target bilayers: (1) the original assay for monitoring binding of the EnvA ectodomain (EnvA-PI) to target membranes (liposomes), (2) a modified and miniaturized EnvA-PI-liposome binding assay, and ...
Judith M. White, Laurie J Earp, Sue E. Delos, Lorraine D. Hernandez   +3 more
openaire   +4 more sources

Surfactant Proteins A and D: Trimerized Innate Immunity Proteins with an Affinity for Viral Fusion Proteins. [PDF]

J Innate Immun, 2019
Innate recognition of viruses is an essential part of the immune response to viral pathogens. This is integral to the maintenance of healthy lungs, which are free from infection and efficient at gaseous exchange. An important component of innate immunity for identifying viruses is the family of C-type collagen-containing lectins, also known as ...
Watson A, Phipps MJS, Clark HW, Skylaris CK, Madsen J.   +4 more
europepmc   +6 more sources

Identification and Characteristics of Fusion Peptides Derived From Enveloped Viruses

Frontiers in Chemistry, 2021
Membrane fusion events allow enveloped viruses to enter and infect cells. The study of these processes has led to the identification of a number of proteins that mediate this process. These proteins are classified according to their structure, which vary
Camille Lozada, Camille Lozada, Thomas M. A. Barlow, Simon Gonzalez, Nadège Lubin-Germain, Steven Ballet   +5 more
doaj   +1 more source

Molecular Modeling of Viral Type I Fusion Proteins: Inhibitors of Influenza Virus Hemagglutinin and the Spike Protein of Coronavirus

Viruses, 2023
The fusion of viral and cell membranes is one of the basic processes in the life cycles of viruses. A number of enveloped viruses confer fusion of the viral envelope and the cell membrane using surface viral fusion proteins.
Sophia S. Borisevich, Vladimir V. Zarubaev, Dmitriy N. Shcherbakov, Olga I. Yarovaya, Nariman F. Salakhutdinov   +4 more
doaj   +1 more source

Class III Viral Membrane Fusion Proteins [PDF]

Current Opinion in Structural Biology, 2009
Accumulating structural studies of viral fusion glycoproteins have revealed unanticipated structural relationships between unrelated virus families and allowed the grouping of these membrane fusogens into three distinct classes. Here we review the newly identified group of class III viral fusion proteins, whose members include fusion proteins from ...
Theodore S. Jardetzky, Marija Backovic
openaire   +5 more sources

New Biophysical Approaches Reveal the Dynamics and Mechanics of Type I Viral Fusion Machinery and Their Interplay with Membranes

Viruses, 2020
Protein-mediated membrane fusion is a highly regulated biological process essential for cellular and organismal functions and infection by enveloped viruses. During viral entry the membrane fusion reaction is catalyzed by specialized protein machinery on
Mark A. Benhaim, Kelly K. Lee
doaj   +1 more source

New insights into the role of endosomal proteins for African swine fever virus infection.

PLoS Pathogens, 2022
African swine fever virus (ASFV) infectious cycle starts with the viral adsorption and entry into the host cell. Then, the virus is internalized via clathrin/dynamin mediated endocytosis and macropinocytosis.
Miguel Ángel Cuesta-Geijo, Isabel García-Dorival, Ana Del Puerto, Jesús Urquiza, Inmaculada Galindo, Lucía Barrado-Gil, Fátima Lasala, Ana Cayuela, Carlos Oscar S Sorzano, Carmen Gil, Rafael Delgado, Covadonga Alonso   +11 more
doaj   +1 more source

A Frame-by-Frame Glance at Membrane Fusion Mechanisms: From Viral Infections to Fertilization

Biomolecules, 2023
Viral entry and fertilization are distinct biological processes that share a common mechanism: membrane fusion. In viral entry, enveloped viruses attach to the host cell membrane, triggering a series of conformational changes in the viral fusion proteins.
Farshad C. Azimi, Trevor T. Dean, Karine Minari, Luis G. M. Basso, Tyler D. R. Vance, Vitor Hugo B. Serrão   +5 more
doaj   +1 more source

A fusion-inhibiting peptide against Rift Valley fever virus inhibits multiple, diverse viruses. [PDF]

PLoS Neglected Tropical Diseases, 2013
For enveloped viruses, fusion of the viral envelope with a cellular membrane is critical for a productive infection to occur. This fusion process is mediated by at least three classes of fusion proteins (Class I, II, and III) based on the protein ...
Jeffrey W Koehler, Jeffrey M Smith, Daniel R Ripoll, Kristin W Spik, Shannon L Taylor, Catherine V Badger, Rebecca J Grant, Monica M Ogg, Anders Wallqvist, Mary C Guttieri, Robert F Garry, Connie S Schmaljohn   +11 more
doaj   +1 more source

Computational epitope mapping of class I fusion proteins using low complexity supervised learning methods.

PLoS Computational Biology, 2022
Antibody epitope mapping of viral proteins plays a vital role in understanding immune system mechanisms of protection. In the case of class I viral fusion proteins, recent advances in cryo-electron microscopy and protein stabilization techniques have ...
Marion F S Fischer, James E Crowe, Jens Meiler   +2 more
doaj   +1 more source