Results 31 to 40 of about 603,967 (361)
Viruses, 2023 The fusion of viral and cell membranes is one of the basic processes in the life cycles of viruses. A number of enveloped viruses confer fusion of the viral envelope and the cell membrane using surface viral fusion proteins.
Sophia S. Borisevich +4 more
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Small-Molecule Inhibition of Viral Fusion Glycoproteins.
Annual Review of Virology, 2021 Viral fusion glycoproteins catalyze membrane fusion during viral entry. Unlike most enzymes, however, they lack a conventional active site in which formation or scission of a specific covalent bond is catalyzed.
Hansong Liu, Priscilla L. Yang
semanticscholar +1 more source
Mechanism of Membrane Fusion by Viral Envelope Proteins
, 2005 Enveloped viruses enter cells by fusing their lipid bilayer membrane with a cellular membrane. Most viral fusion proteins require priming by proteolytic processing, either of the fusion protein itself or of an accompanying protein. The priming step, which often occurs during transport of the fusion protein to the cell surface but may also occur ...
Stephen C. Harrison
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IFITM Proteins Incorporated into HIV-1 Virions Impair Viral Fusion and Spread [PDF]
Cell Host & Microbe, 2014 The interferon-induced transmembrane (IFITM) proteins protect cells from diverse virus infections by inhibiting virus-cell fusion. IFITM proteins also inhibit HIV-1 replication through mechanisms only partially understood. We show that when expressed in uninfected lymphocytes, IFITM proteins exert protective effects during cell-free virus infection ...
Alex A. Compton +8 more
semanticscholar +4 more sources
New insights into the role of endosomal proteins for African swine fever virus infection.
PLoS Pathogens, 2022 African swine fever virus (ASFV) infectious cycle starts with the viral adsorption and entry into the host cell. Then, the virus is internalized via clathrin/dynamin mediated endocytosis and macropinocytosis.
Miguel Ángel Cuesta-Geijo +11 more
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A fusion-inhibiting peptide against Rift Valley fever virus inhibits multiple, diverse viruses. [PDF]
PLoS Neglected Tropical Diseases, 2013 For enveloped viruses, fusion of the viral envelope with a cellular membrane is critical for a productive infection to occur. This fusion process is mediated by at least three classes of fusion proteins (Class I, II, and III) based on the protein ...
Jeffrey W Koehler +11 more
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A Frame-by-Frame Glance at Membrane Fusion Mechanisms: From Viral Infections to Fertilization
Biomolecules, 2023 Viral entry and fertilization are distinct biological processes that share a common mechanism: membrane fusion. In viral entry, enveloped viruses attach to the host cell membrane, triggering a series of conformational changes in the viral fusion proteins.
Farshad C. Azimi +5 more
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Viruses, 2022 The membrane surface of enveloped viruses contains dedicated proteins enabling the fusion of the viral with the host cell membrane. Working with these proteins is almost always challenging because they are membrane-embedded and naturally metastable ...
Henriette Ebel +2 more
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PLoS Computational Biology, 2022 Antibody epitope mapping of viral proteins plays a vital role in understanding immune system mechanisms of protection. In the case of class I viral fusion proteins, recent advances in cryo-electron microscopy and protein stabilization techniques have ...
Marion F S Fischer +2 more
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The transmembrane domain and acidic lipid flip-flop regulates voltage-dependent fusion mediated by class II and III viral proteins. [PDF]
PLoS ONE, 2013 Voltage dependence of fusion induced by class II and class III viral fusion proteins was investigated. Class II proteins from Ross River and Sindbus virus and a mutant class III protein from Epstein Barr virus were found to induce cell-cell fusion that ...
Ruben M Markosyan, Fredric S Cohen
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