IFITM proteins restrict viral membrane hemifusion.
PLoS Pathogens, 2013 The interferon-inducible transmembrane (IFITM) protein family represents a new class of cellular restriction factors that block early stages of viral replication; the underlying mechanism is currently not known.
Kun Li +12 more
doaj +1 more source
SARS-CoV-2 Fusion Peptide Conjugated to a Tetravalent Dendrimer Selectively Inhibits Viral Infection
Pharmaceutics, 2023 Fusion is a key event for enveloped viruses, through which viral and cell membranes come into close contact. This event is mediated by viral fusion proteins, which are divided into three structural and functional classes.
Carla Zannella +10 more
doaj +1 more source
Viruses, 2019 Fusion of viral and cellular membranes is a key step during the viral life cycle. Enveloped viruses trigger this process by means of specialized viral proteins expressed on their surface, the so-called viral fusion proteins.
María J. García-Murria +4 more
doaj +1 more source
Common principles and intermediates of viral protein-mediated fusion: the HIV-1 paradigm
Retrovirology, 2008 Enveloped viruses encode specialized fusion proteins which promote the merger of viral and cell membranes, permitting the cytosolic release of the viral cores.
Melikyan Gregory B
doaj +1 more source
Influence of N-glycosylation on Expression and Function of Pseudorabies Virus Glycoprotein gB
Pathogens, 2021 Envelope glycoprotein (g)B is conserved throughout the Herpesviridae and mediates fusion of the viral envelope with cellular membranes for infectious entry and spread.
Melina Vallbracht +2 more
doaj +1 more source
Rubella Virus: First Calcium-Requiring Viral Fusion Protein
PLoS Pathogens, 2014 Rubella virus (RuV) infection of pregnant women can cause fetal death, miscarriage, or severe fetal malformations, and remains a significant health problem in much of the underdeveloped world. RuV is a small enveloped RNA virus that infects target cells by receptor-mediated endocytosis and low pH-dependent membrane fusion.
Mathieu Dubé +2 more
openaire +4 more sources
Class II Membrane Fusion Proteins in Viral and Cellular Fusion Events [PDF]
Biophysical Journal, 2013 Class II proteins are viral membrane fusogenic molecules folded essentially as beta-sheet and having an internal fusion peptide. In particular, they lack the characteristic central alpha-helical coiled coil present in the post-fusion conformation of all other viral fusion proteins. The regular, symmetric enveloped viruses that have been studied so far,
Rey, Félix +3 more
openaire +1 more source
Conformational reorganization of the SARS coronavirus spike following receptor binding: implications for membrane fusion. [PDF]
PLoS ONE, 2007 The SARS coronavirus (SARS-CoV) spike is the largest known viral spike molecule, and shares a similar function with all class 1 viral fusion proteins.
Daniel R Beniac +4 more
doaj +1 more source
A compact, multifunctional fusion module directs cholesterol-dependent homomultimerization and syncytiogenic efficiency of reovirus p10 FAST proteins. [PDF]
PLoS Pathogens, 2014 The homologous p10 fusion-associated small transmembrane (FAST) proteins of the avian (ARV) and Nelson Bay (NBV) reoviruses are the smallest known viral membrane fusion proteins, and are virulence determinants of the fusogenic reoviruses.
Tim Key, Roy Duncan
doaj +1 more source
Frontiers in Microbiology, 2021 The SARS-CoV-2 viral genome contains a positive-strand single-stranded RNA of ∼30 kb. Human ACE2 protein is the receptor for SARS-CoV-2 virus attachment and infection.
Shuang-yong Xu +3 more
doaj +1 more source