Upstream-binding factor is sequestered into herpes simplex virus type 1 replication compartments [PDF]
Previous reports have shown that adenovirus recruits nucleolar protein upstream-binding factor (UBF) into adenovirus DNA replication centres. Here, we report that despite having a different mode of viral DNA replication, herpes simplex virus type 1 (HSV ...
Ahmed+25 more
core +2 more sources
Structure of the Core Postfusion Porcine Endogenous Retrovirus Fusion Protein
Retroviral elements from endogenous retroviruses have functions in mammalian physiology. The best-known examples are the envelope proteins that function in placenta development and immune suppression.
Trevor T. Dean+2 more
doaj +1 more source
Receptor-Activated Binding of Viral Fusion Proteins to Target Membranes
This chapter describes three assays to monitor receptor-induced association of the envelope glycoprotein (EnvA) of avian sarcoma/leukosis virus (ASLV) with target bilayers: (1) the original assay for monitoring binding of the EnvA ectodomain (EnvA-PI) to target membranes (liposomes), (2) a modified and miniaturized EnvA-PI-liposome binding assay, and ...
Laurie J. Earp+3 more
openalex +4 more sources
Mechanism of membrane fusion induced by vesicular stomatitis virus G protein [PDF]
The glycoproteins (G proteins) of vesicular stomatitis virus (VSV) and related rhabdoviruses (e.g., rabies virus) mediate both cell attachment and membrane fusion.
Harrison, Stephen C.+6 more
core +2 more sources
Membrane fusion proteins are responsible for viral entry into host cells—a crucial first step in viral infection. These proteins undergo large conformational changes from pre-fusion to fusion-initiation structures, and, despite differences in viral
Anna Lappala+8 more
doaj +1 more source
Functional analysis of the Bunyamwera orthobunyavirus Gc glycoprotein [PDF]
The virion glycoproteins Gn and Gc of Bunyamwera orthobunyavirus (family Bunyaviridae) are encoded by the M RNA genome segment and have roles in both viral attachment and membrane fusion.
Brauburger, K.+4 more
core +2 more sources
Inhibition of the Hantavirus Fusion Process by Predicted Domain III and Stem Peptides from Glycoprotein Gc. [PDF]
Hantaviruses can cause hantavirus pulmonary syndrome or hemorrhagic fever with renal syndrome in humans. To enter cells, hantaviruses fuse their envelope membrane with host cell membranes.
Gonzalo P Barriga+9 more
doaj +1 more source
SARS-CoV-2 Fusion Peptide Conjugated to a Tetravalent Dendrimer Selectively Inhibits Viral Infection
Fusion is a key event for enveloped viruses, through which viral and cell membranes come into close contact. This event is mediated by viral fusion proteins, which are divided into three structural and functional classes.
Carla Zannella+10 more
doaj +1 more source
The interferon-stimulated gene IFITM3 restricts infection and pathogenesis of arthritogenic and encephalitic alphaviruses [PDF]
Host cells respond to viral infections by producing type I interferon (IFN), which induces the expression of hundreds of interferon-stimulated genes (ISGs).
Diamond, Michael S+4 more
core +2 more sources
Hydrophobic-at-Interface Regions in Viral Fusion Protein Ectodomains [PDF]
In this chapter we shall describe how to apply the hydrophobicity-at-interface scale, as proposed by Wimley and White [Wimley, W. C. and White, S. H. (1996) Nature Struct. Biol. 3:842–848], to the detection of amino acid sequences of viral envelope glycoproteins putatively engaged in interactions with the target membranes.
José L. Nieva, Tatiana Suárez
openaire +2 more sources