Inhibition of the Hantavirus Fusion Process by Predicted Domain III and Stem Peptides from Glycoprotein Gc. [PDF]
PLoS Neglected Tropical Diseases, 2016 Hantaviruses can cause hantavirus pulmonary syndrome or hemorrhagic fever with renal syndrome in humans. To enter cells, hantaviruses fuse their envelope membrane with host cell membranes.
Gonzalo P Barriga +9 more
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Structure of the Core Postfusion Porcine Endogenous Retrovirus Fusion Protein
mBio, 2022 Retroviral elements from endogenous retroviruses have functions in mammalian physiology. The best-known examples are the envelope proteins that function in placenta development and immune suppression.
Trevor T. Dean +2 more
doaj +1 more source
A multitask transfer learning framework for the prediction of virus-human protein-protein interactions [PDF]
BMC Bioinformatics 2021, 2021 Viral infections are causing significant morbidity and mortality worldwide. Understanding the interaction patterns between a particular virus and human proteins plays a crucial role in unveiling the underlying mechanism of viral infection and pathogenesis. This could further help in the prevention and treatment of virus-related diseases.
arxiv +1 more source
Hydrophobic-at-Interface Regions in Viral Fusion Protein Ectodomains [PDF]
Bioscience Reports, 2000 In this chapter we shall describe how to apply the hydrophobicity-at-interface scale, as proposed by Wimley and White [Wimley, W. C. and White, S. H. (1996) Nature Struct. Biol. 3:842–848], to the detection of amino acid sequences of viral envelope glycoproteins putatively engaged in interactions with the target membranes.
José L. Nieva, Tatiana Suárez
openaire +2 more sources
Viral Membrane Fusion Proteins and RNA Sorting Mechanisms for the Molecular Delivery by Exosomes [PDF]
Cells, 2021 The advancement of precision medicine critically depends on the robustness and specificity of the carriers used for the targeted delivery of effector molecules in the human body. Numerous nanocarriers have been explored in vivo, to ensure the precise delivery of molecular cargos via tissue-specific targeting, including the endocrine part of the ...
Nikolay Barlev +9 more
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SARS-CoV-2 Fusion Peptide Conjugated to a Tetravalent Dendrimer Selectively Inhibits Viral Infection
Pharmaceutics, 2023 Fusion is a key event for enveloped viruses, through which viral and cell membranes come into close contact. This event is mediated by viral fusion proteins, which are divided into three structural and functional classes.
Carla Zannella +10 more
doaj +1 more source
Fusoselect: cell–cell fusion activity engineered by directed evolution of a retroviral glycoprotein [PDF]
, 2005 Membrane fusion plays a key role in many biological processes including vesicle trafficking, synaptic transmission, fertilization or cell entry of enveloped viruses. As a common feature the fusion process is mediated by distinct membrane proteins.
Braun, Gundula +5 more
core +4 more sources
IFITM proteins restrict viral membrane hemifusion.
PLoS Pathogens, 2013 The interferon-inducible transmembrane (IFITM) protein family represents a new class of cellular restriction factors that block early stages of viral replication; the underlying mechanism is currently not known.
Kun Li +12 more
doaj +1 more source
Role of electrostatic interactions in the assembly of empty spherical viral capsids [PDF]
Phys. Rev. E 76, 061906 (2007), 2007 We examine the role of electrostatic interactions in the assembly of empty spherical viral capsids. The charges on the protein subunits that make the viral capsid mutually interact and are expected to yield electrostatic repulsion acting against the assembly of capsids.
arxiv +1 more source
The structure of a prokaryotic viral envelope protein expands the landscape of membrane fusion proteins [PDF]
Nature Communications, 2019 AbstractLipid membrane fusion is an essential function in many biological processes. Detailed mechanisms of membrane fusion and the protein structures involved have been mainly studied in eukaryotic systems, whereas very little is known about membrane fusion in prokaryotes.
Eduardo A Bignon +19 more
openaire +4 more sources